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Hematinic deficiencies and anemia statuses in oral mucosal disease patients with folic acid deficiency.

Abstract

BACKGROUND/PURPOSE

Folic acid deficiency (FAD) may result in macrocytic anemia. This study assessed the hematinic deficiencies and anemia statuses in oral mucosal disease patients with FAD (defined as folic acid ≤ 6 ng/mL).

METHODS

The blood hemoglobin (Hb), iron, vitamin B12, and folic acid concentrations, serum gastric parietal cell antibody level, and mean corpuscular volume (MCV) in 198 oral mucosal disease patients with FAD were measured. Based on World Health Organization (WHO) criteria, anemia or Hb deficiency was defined as having an Hb concentration of <13 g/dL for men and <12 g/dL for women. In this study, macrocytic anemia due to FAD was defined as having an MCV ≥100 fL and folic acid ≤6 ng/mL; pernicious anemia as having MCV ≥100 fL, vitamin B12 < 200 pg/mL, and serum gastric parietal cell antibody positivity; iron deficiency anemia as having MCV <80 fL and iron <60 μg/dL; and thalassemia trait as having MCV <74 fL, red blood cell (RBC) count > 5.0 × 10(12)/L, and Mentzer index (MCV/RBC) < 13.

RESULTS

We found that by WHO definitions, 73 (36.9%), 41 (20.7%), and 10 (5.1%) of our 198 FAD patients had concomitant Hb, iron, and vitamin B12 deficiencies, respectively. Of 73 anemic FAD patients, three had macrocytic anemia due to FAD, one had pernicious anemia, 14 had iron deficiency anemia, eight had thalassemia trait, and the resting 47 had normocytic anemia.

CONCLUSION

In addition to macrocytic anemia (2.0%), FAD patients may have concomitant normocytic (23.7%) or microcytic (11.1%) anemia.

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  • Authors+Show Affiliations

    ,

    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.

    ,

    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.

    ,

    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.

    ,

    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.

    ,

    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.

    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: andysun7702@yahoo.com.tw.

    Source

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Anemia, Iron-Deficiency
    Anemia, Macrocytic
    Autoantibodies
    Case-Control Studies
    Erythrocyte Indices
    Female
    Folic Acid
    Folic Acid Deficiency
    Hemoglobins
    Humans
    Iron
    Male
    Middle Aged
    Mouth Diseases
    Parietal Cells, Gastric
    Taiwan
    Vitamin B 12
    Vitamin B 12 Deficiency
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    26187724

    Citation

    Chang, Julia Yu-Fong, et al. "Hematinic Deficiencies and Anemia Statuses in Oral Mucosal Disease Patients With Folic Acid Deficiency." Journal of the Formosan Medical Association = Taiwan Yi Zhi, vol. 114, no. 9, 2015, pp. 806-12.
    Chang JY, Wang YP, Wu YC, et al. Hematinic deficiencies and anemia statuses in oral mucosal disease patients with folic acid deficiency. J Formos Med Assoc. 2015;114(9):806-12.
    Chang, J. Y., Wang, Y. P., Wu, Y. C., Cheng, S. J., Chen, H. M., & Sun, A. (2015). Hematinic deficiencies and anemia statuses in oral mucosal disease patients with folic acid deficiency. Journal of the Formosan Medical Association = Taiwan Yi Zhi, 114(9), pp. 806-12. doi:10.1016/j.jfma.2015.06.006.
    Chang JY, et al. Hematinic Deficiencies and Anemia Statuses in Oral Mucosal Disease Patients With Folic Acid Deficiency. J Formos Med Assoc. 2015;114(9):806-12. PubMed PMID: 26187724.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hematinic deficiencies and anemia statuses in oral mucosal disease patients with folic acid deficiency. AU - Chang,Julia Yu-Fong, AU - Wang,Yi-Ping, AU - Wu,Yang-Che, AU - Cheng,Shih-Jung, AU - Chen,Hsin-Ming, AU - Sun,Andy, Y1 - 2015/07/15/ PY - 2015/05/25/received PY - 2015/06/09/accepted PY - 2015/7/19/entrez PY - 2015/7/19/pubmed PY - 2016/11/15/medline KW - folic acid KW - macrocytic anemia KW - microcytic anemia KW - normocytic anemia KW - pernicious anemia KW - vitamin B(12) SP - 806 EP - 12 JF - Journal of the Formosan Medical Association = Taiwan yi zhi JO - J. Formos. Med. Assoc. VL - 114 IS - 9 N2 - BACKGROUND/PURPOSE: Folic acid deficiency (FAD) may result in macrocytic anemia. This study assessed the hematinic deficiencies and anemia statuses in oral mucosal disease patients with FAD (defined as folic acid ≤ 6 ng/mL). METHODS: The blood hemoglobin (Hb), iron, vitamin B12, and folic acid concentrations, serum gastric parietal cell antibody level, and mean corpuscular volume (MCV) in 198 oral mucosal disease patients with FAD were measured. Based on World Health Organization (WHO) criteria, anemia or Hb deficiency was defined as having an Hb concentration of <13 g/dL for men and <12 g/dL for women. In this study, macrocytic anemia due to FAD was defined as having an MCV ≥100 fL and folic acid ≤6 ng/mL; pernicious anemia as having MCV ≥100 fL, vitamin B12 < 200 pg/mL, and serum gastric parietal cell antibody positivity; iron deficiency anemia as having MCV <80 fL and iron <60 μg/dL; and thalassemia trait as having MCV <74 fL, red blood cell (RBC) count > 5.0 × 10(12)/L, and Mentzer index (MCV/RBC) < 13. RESULTS: We found that by WHO definitions, 73 (36.9%), 41 (20.7%), and 10 (5.1%) of our 198 FAD patients had concomitant Hb, iron, and vitamin B12 deficiencies, respectively. Of 73 anemic FAD patients, three had macrocytic anemia due to FAD, one had pernicious anemia, 14 had iron deficiency anemia, eight had thalassemia trait, and the resting 47 had normocytic anemia. CONCLUSION: In addition to macrocytic anemia (2.0%), FAD patients may have concomitant normocytic (23.7%) or microcytic (11.1%) anemia. SN - 0929-6646 UR - https://www.unboundmedicine.com/medline/citation/26187724/Hematinic_deficiencies_and_anemia_statuses_in_oral_mucosal_disease_patients_with_folic_acid_deficiency_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-6646(15)00229-6 DB - PRIME DP - Unbound Medicine ER -