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Association between the IL1B -31C > T polymorphism and Helicobacter pylori infection in Asian and Latin American population: A meta-analysis.
Microb Pathog. 2015 Sep; 86:45-52.MP

Abstract

BACKGROUND

Host genetic factors that control the production of cytokines, including interleukin-1β (IL-1β), possibly affect susceptibility to many Helicobacter pylori-related diseases. There is a complex interplay between H. pylori infection, the subsequent production of certain cytokines, and H. pylori-related diseases. We conducted a meta-analysis to clarify the association between the IL1B -31C > T polymorphism and H. pylori infection, and possible subsequent pathogenic mechanisms.

METHODS

Published literature contained within PubMed, Embase, and the Cochrane Library was used in our meta-analysis. Data were analyzed with the STATA 13.1 software package using pooled odds ratios (ORs) with 95% confidence intervals (95% CI). Egger's regression test, Begg's rank correlation test, and Begg's funnel plot were used to test publication bias.

RESULTS

A total of 12 case-control studies comprising 5827 subjects (3335 cases and 2492 controls) were available for our meta-analysis. The IL1B -31C > T polymorphism was associated with an increased risk of H. pylori infection in Asian and Latin American population (TT + CT vs. CC, OR = 1.29, 95% CI = 1.14-1.46; TT vs. CT + CC, OR = 1.23, 95% CI = 1.09-1.39; TT vs. CC, OR = 1.43, 95% CI = 1.22-1.67; T allele vs. C allele, OR = 1.19, 95% CI = 1.10-1.29). A significant association was also found for all genetic models in various subgroups (cancer and no-cancer, hospital- and population-based).

CONCLUSION

Our meta-analysis demonstrated that IL1B -31C > T polymorphism might increase H. pylori infection risk in Asian and Latin American population. Further studies with different ethnicities and larger sample size are required to validate this result.

Authors+Show Affiliations

Department of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.Department of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.Department of Gastroenterology, Second Hospital of Gansu Province, Lanzhou 730000, China.Department of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.Department of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China. Electronic address: hanj@lzu.edu.cn.Department of Gastroenterology, Second Hospital of Gansu Province, Lanzhou 730000, China. Electronic address: zjh51272@163.com.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26188264

Citation

Sun, Xudong, et al. "Association Between the IL1B -31C > T Polymorphism and Helicobacter Pylori Infection in Asian and Latin American Population: a Meta-analysis." Microbial Pathogenesis, vol. 86, 2015, pp. 45-52.
Sun X, Xu Y, Zhang F, et al. Association between the IL1B -31C > T polymorphism and Helicobacter pylori infection in Asian and Latin American population: A meta-analysis. Microb Pathog. 2015;86:45-52.
Sun, X., Xu, Y., Zhang, F., Jing, T., Han, J., & Zhang, J. (2015). Association between the IL1B -31C > T polymorphism and Helicobacter pylori infection in Asian and Latin American population: A meta-analysis. Microbial Pathogenesis, 86, 45-52. https://doi.org/10.1016/j.micpath.2015.07.010
Sun X, et al. Association Between the IL1B -31C > T Polymorphism and Helicobacter Pylori Infection in Asian and Latin American Population: a Meta-analysis. Microb Pathog. 2015;86:45-52. PubMed PMID: 26188264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between the IL1B -31C > T polymorphism and Helicobacter pylori infection in Asian and Latin American population: A meta-analysis. AU - Sun,Xudong, AU - Xu,Yuanyuan, AU - Zhang,Fuhua, AU - Jing,Tao, AU - Han,Jian, AU - Zhang,Jinhua, Y1 - 2015/07/15/ PY - 2015/06/01/received PY - 2015/07/11/revised PY - 2015/07/13/accepted PY - 2015/7/19/entrez PY - 2015/7/19/pubmed PY - 2016/5/5/medline KW - Helicobacter pylori KW - Interleukin-1β KW - Meta-analysis KW - Polymorphism SP - 45 EP - 52 JF - Microbial pathogenesis JO - Microb Pathog VL - 86 N2 - BACKGROUND: Host genetic factors that control the production of cytokines, including interleukin-1β (IL-1β), possibly affect susceptibility to many Helicobacter pylori-related diseases. There is a complex interplay between H. pylori infection, the subsequent production of certain cytokines, and H. pylori-related diseases. We conducted a meta-analysis to clarify the association between the IL1B -31C > T polymorphism and H. pylori infection, and possible subsequent pathogenic mechanisms. METHODS: Published literature contained within PubMed, Embase, and the Cochrane Library was used in our meta-analysis. Data were analyzed with the STATA 13.1 software package using pooled odds ratios (ORs) with 95% confidence intervals (95% CI). Egger's regression test, Begg's rank correlation test, and Begg's funnel plot were used to test publication bias. RESULTS: A total of 12 case-control studies comprising 5827 subjects (3335 cases and 2492 controls) were available for our meta-analysis. The IL1B -31C > T polymorphism was associated with an increased risk of H. pylori infection in Asian and Latin American population (TT + CT vs. CC, OR = 1.29, 95% CI = 1.14-1.46; TT vs. CT + CC, OR = 1.23, 95% CI = 1.09-1.39; TT vs. CC, OR = 1.43, 95% CI = 1.22-1.67; T allele vs. C allele, OR = 1.19, 95% CI = 1.10-1.29). A significant association was also found for all genetic models in various subgroups (cancer and no-cancer, hospital- and population-based). CONCLUSION: Our meta-analysis demonstrated that IL1B -31C > T polymorphism might increase H. pylori infection risk in Asian and Latin American population. Further studies with different ethnicities and larger sample size are required to validate this result. SN - 1096-1208 UR - https://www.unboundmedicine.com/medline/citation/26188264/Association_between_the_IL1B__31C_>_T_polymorphism_and_Helicobacter_pylori_infection_in_Asian_and_Latin_American_population:_A_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0882-4010(15)00110-2 DB - PRIME DP - Unbound Medicine ER -