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Attention Deficit Hyperactivity Disorder and oxidative stress: A short term follow up study.

Abstract

In this study, we aimed to investigate total antioxidative status (TAS) and total oxidative status (TOS) of plasma and antioxidant enzymes such as paraoxonase (PON), stimulated paraoxonase (SPON), arylesterase (ARES) and thiols in plasma of children and adolescents with Attention Deficit Hyperactivity Disorder (ADHD). In the second step. this study aimed to reveal the possible effects of ADHD treatment on these parameters. Fifty-six patients with ADHD and 52 healthy controls were involved in this study. Venous blood samples were collected and oxidative and antioxidative parameter's were studied. In the second phase of the study, blood samples were taken from patients using medication. Pre-treatment oxidative stress index (OSI) values and the plasma TOS levels of the patients with ADHD were statistically higher than those of the control group. The plasma thiol levels of the patients with ADHD were significantly lower than the control group. The post-treatment plasma antioxidative parameter's levels were significantly higher than the pre-treatment levels. The post-treatment oxidative stress index value was significantly lower than the pre-treatment value. Therefore, oxidative metabolism was found to be impaired in children and adolescents with ADHD. It was also determined that methylphenidate repairs the oxidative balance by increasing antioxidant defence mechanisms.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Gazi University Medical Faculty, Child and Adolescent Psychiatry Department, Ankara, Turkey. Electronic address: dresraguney@gmail.com.

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    Kayseri Training and Research Hospital, Department of Child and Adolescent Psychiatry, Kayseri, Turkey.

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    Yildirim Beyazit University Medical Faculty, Atatürk Training and Research Hospital, Department of Medical Biochemistry, Ankara, Turkey.

    ,

    Gazi University Medical Faculty, Child and Adolescent Psychiatry Department, Ankara, Turkey.

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    Gazi University Medical Faculty, Child and Adolescent Psychiatry Department, Ankara, Turkey.

    ,

    Gazi University Medical Faculty, Child and Adolescent Psychiatry Department, Ankara, Turkey.

    ,

    Gazi University Medical Faculty, Child and Adolescent Psychiatry Department, Ankara, Turkey.

    ,

    Gazi University Medical Faculty, Department of Medical Biochemistry, Ankara, Turkey.

    Yildirim Beyazit University Medical Faculty, Atatürk Training and Research Hospital, Department of Medical Biochemistry, Ankara, Turkey.

    Source

    Psychiatry research 229:1-2 2015 Sep 30 pg 310-7

    MeSH

    Adolescent
    Antioxidants
    Aryldialkylphosphatase
    Attention Deficit Disorder with Hyperactivity
    Biomarkers
    Carboxylic Ester Hydrolases
    Central Nervous System Stimulants
    Child
    Female
    Follow-Up Studies
    Humans
    Male
    Methylphenidate
    Oxidation-Reduction
    Oxidative Stress

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    26188640

    Citation

    Guney, Esra, et al. "Attention Deficit Hyperactivity Disorder and Oxidative Stress: a Short Term Follow Up Study." Psychiatry Research, vol. 229, no. 1-2, 2015, pp. 310-7.
    Guney E, Cetin FH, Alisik M, et al. Attention Deficit Hyperactivity Disorder and oxidative stress: A short term follow up study. Psychiatry Res. 2015;229(1-2):310-7.
    Guney, E., Cetin, F. H., Alisik, M., Tunca, H., Tas Torun, Y., Iseri, E., ... Erel, O. (2015). Attention Deficit Hyperactivity Disorder and oxidative stress: A short term follow up study. Psychiatry Research, 229(1-2), pp. 310-7. doi:10.1016/j.psychres.2015.07.003.
    Guney E, et al. Attention Deficit Hyperactivity Disorder and Oxidative Stress: a Short Term Follow Up Study. Psychiatry Res. 2015 Sep 30;229(1-2):310-7. PubMed PMID: 26188640.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Attention Deficit Hyperactivity Disorder and oxidative stress: A short term follow up study. AU - Guney,Esra, AU - Cetin,Fatih Hilmi, AU - Alisik,Murat, AU - Tunca,Huseyin, AU - Tas Torun,Yasemin, AU - Iseri,Elvan, AU - Isik Taner,Yasemen, AU - Cayci,Banu, AU - Erel,Ozcan, Y1 - 2015/07/08/ PY - 2014/12/24/received PY - 2015/07/02/revised PY - 2015/07/04/accepted PY - 2015/7/20/entrez PY - 2015/7/21/pubmed PY - 2016/4/9/medline KW - Attention Deficit Hyperactivity Disorder KW - Medication KW - Oxidative stress KW - Total antioxidative status KW - Total oxidative status SP - 310 EP - 7 JF - Psychiatry research JO - Psychiatry Res VL - 229 IS - 1-2 N2 - In this study, we aimed to investigate total antioxidative status (TAS) and total oxidative status (TOS) of plasma and antioxidant enzymes such as paraoxonase (PON), stimulated paraoxonase (SPON), arylesterase (ARES) and thiols in plasma of children and adolescents with Attention Deficit Hyperactivity Disorder (ADHD). In the second step. this study aimed to reveal the possible effects of ADHD treatment on these parameters. Fifty-six patients with ADHD and 52 healthy controls were involved in this study. Venous blood samples were collected and oxidative and antioxidative parameter's were studied. In the second phase of the study, blood samples were taken from patients using medication. Pre-treatment oxidative stress index (OSI) values and the plasma TOS levels of the patients with ADHD were statistically higher than those of the control group. The plasma thiol levels of the patients with ADHD were significantly lower than the control group. The post-treatment plasma antioxidative parameter's levels were significantly higher than the pre-treatment levels. The post-treatment oxidative stress index value was significantly lower than the pre-treatment value. Therefore, oxidative metabolism was found to be impaired in children and adolescents with ADHD. It was also determined that methylphenidate repairs the oxidative balance by increasing antioxidant defence mechanisms. SN - 1872-7123 UR - https://www.unboundmedicine.com/medline/citation/26188640/Attention_Deficit_Hyperactivity_Disorder_and_oxidative_stress:_A_short_term_follow_up_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(15)00448-5 DB - PRIME DP - Unbound Medicine ER -