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Clinical characteristics of leg restlessness in Parkinson's disease compared with idiopathic Restless Legs Syndrome.
J Neurol Sci. 2015 Oct 15; 357(1-2):109-14.JN

Abstract

OBJECTIVE

There is limited data on motor restlessness in Parkinson's disease (PD). Here we evaluate for clinical differences between cohorts of idiopathic Restless Legs Syndrome (iRLS), PD patients with leg restlessness, and PD with RLS.

METHODS

We examined 276 consecutive PD patients for leg restlessness symptoms, we compared clinical features of PD patients with RLS, PD patients with leg restlessness but not meeting RLS criteria, PD patient without RLS and iRLS.

RESULTS

A total of 262 PD patients who satisfied the inclusion criteria were analyzed. After excluding 23 possible secondary RLS or mimics, 28 were diagnosed with RLS and 18 with leg motor restlessness (LMR). Compared with iRLS patients, PD patients with RLS or LMR had older age of RLS/LMR onset, shorter duration of leg restlessness, less positive family history, different seasonal trends and more unilaterality of leg restlessness symptom (P<0.01) which were often in accordance with dominant Parkinsonism side and related with Parkinsonism severity. PD patients with RLS/LMR had lower daily dosage (P<0.01) and shorter duration (P<0.05) of dopaminergic medication when RLS/LMR symptom onset than PD without leg restlessness. PD with LMR had less severe Parkinsonism (P<0.05) and leg restlessness (P<0.01) symptoms than PD with RLS.

CONCLUSION

Clinical characteristics of PD patients with RLS and LMR were different from iRLS, differentiating these various subtypes can facilitate optimal treatment.

Authors+Show Affiliations

Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China.Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China.Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China.Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China.Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China.Department of Neurology, University of Texas Health Science Center Houston, Houston, TX, USA.Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Outram Road, Singapore.Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China. Electronic address: yunchw@medmail.com.cn.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26189051

Citation

Zhu, Xiao-Ying, et al. "Clinical Characteristics of Leg Restlessness in Parkinson's Disease Compared With Idiopathic Restless Legs Syndrome." Journal of the Neurological Sciences, vol. 357, no. 1-2, 2015, pp. 109-14.
Zhu XY, Liu Y, Zhang XJ, et al. Clinical characteristics of leg restlessness in Parkinson's disease compared with idiopathic Restless Legs Syndrome. J Neurol Sci. 2015;357(1-2):109-14.
Zhu, X. Y., Liu, Y., Zhang, X. J., Yang, W. H., Feng, Y., Ondo, W. G., Tan, E. K., & Wu, Y. C. (2015). Clinical characteristics of leg restlessness in Parkinson's disease compared with idiopathic Restless Legs Syndrome. Journal of the Neurological Sciences, 357(1-2), 109-14. https://doi.org/10.1016/j.jns.2015.07.008
Zhu XY, et al. Clinical Characteristics of Leg Restlessness in Parkinson's Disease Compared With Idiopathic Restless Legs Syndrome. J Neurol Sci. 2015 Oct 15;357(1-2):109-14. PubMed PMID: 26189051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical characteristics of leg restlessness in Parkinson's disease compared with idiopathic Restless Legs Syndrome. AU - Zhu,Xiao-Ying, AU - Liu,Ye, AU - Zhang,Xiao-Jin, AU - Yang,Wen-Hao, AU - Feng,Ya, AU - Ondo,William G, AU - Tan,Eng-King, AU - Wu,Yun-Cheng, Y1 - 2015/07/09/ PY - 2015/05/05/received PY - 2015/07/05/revised PY - 2015/07/06/accepted PY - 2015/7/20/entrez PY - 2015/7/21/pubmed PY - 2016/9/14/medline KW - Chinese KW - Clinical characteristics KW - Dopaminergic KW - Leg Motor Restlessness KW - Parkinson's disease KW - Restless Legs Syndrome SP - 109 EP - 14 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 357 IS - 1-2 N2 - OBJECTIVE: There is limited data on motor restlessness in Parkinson's disease (PD). Here we evaluate for clinical differences between cohorts of idiopathic Restless Legs Syndrome (iRLS), PD patients with leg restlessness, and PD with RLS. METHODS: We examined 276 consecutive PD patients for leg restlessness symptoms, we compared clinical features of PD patients with RLS, PD patients with leg restlessness but not meeting RLS criteria, PD patient without RLS and iRLS. RESULTS: A total of 262 PD patients who satisfied the inclusion criteria were analyzed. After excluding 23 possible secondary RLS or mimics, 28 were diagnosed with RLS and 18 with leg motor restlessness (LMR). Compared with iRLS patients, PD patients with RLS or LMR had older age of RLS/LMR onset, shorter duration of leg restlessness, less positive family history, different seasonal trends and more unilaterality of leg restlessness symptom (P<0.01) which were often in accordance with dominant Parkinsonism side and related with Parkinsonism severity. PD patients with RLS/LMR had lower daily dosage (P<0.01) and shorter duration (P<0.05) of dopaminergic medication when RLS/LMR symptom onset than PD without leg restlessness. PD with LMR had less severe Parkinsonism (P<0.05) and leg restlessness (P<0.01) symptoms than PD with RLS. CONCLUSION: Clinical characteristics of PD patients with RLS and LMR were different from iRLS, differentiating these various subtypes can facilitate optimal treatment. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/26189051/Clinical_characteristics_of_leg_restlessness_in_Parkinson's_disease_compared_with_idiopathic_Restless_Legs_Syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(15)00429-3 DB - PRIME DP - Unbound Medicine ER -