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Anti-fibrotic effects of the Masson pine pollen aqueous extract on hepatic fibrosis rat model.
Int J Clin Exp Pathol. 2015; 8(5):4651-61.IJ

Abstract

AIM

To observe the antifibrotic effects of Masson Pine Pollen aqueous extract.

METHODS

Adult Sprague-Dawley rats were randomly divided into control (CG), hepatic fibrosis model (MG), MPPAE low dose (LG), MPPAE high dose (HG), and MPP original powder (MPPOP; OG) groups. Each group was treated with specific protocols and sacrificed 8 weeks later. Multiple indicators such as serum transaminase, HE staining of the liver tissue, and relevant indexes to fibrosis were determined.

RESULTS

Severe hyperplasia of fibrous connective tissues was observed in livers of the MG group rats, while aspartate transaminase and alanine transaminase levels and collagen content obviously increased, superoxide dismutase and glutathione peroxidase activities and MMPs expression decreased, malondialdehyde (MDA) and 8-hydroxy-2'-deoxyguanosine concentrations increased, while mRNA expressions of hepatic stellate cell (HSC)-related cytokines such as transforming growth factor-β1 and platelet-derived growth factor, transcription factors such as nuclear factor-κB p65, and signaling protein α-smooth muscle actin were all increased significantly.

CONCLUSIONS

MPPAE effectively inhibited the fibrotic process in this CCl4-induced hepatic fibrosis rat model. It may be associated with synergic functions of antioxidant activity, inhibitory activity on HSC proliferation, collagen synthesis, and MMPs expression induction.

Authors+Show Affiliations

Department of Nutrition, Institute of Health and Environmental Medicine Tianjin 300050, China.International Center for Liver Disease Treatment, 302 Hospital of PLA Beijing 100039, China.Department of Nutrition, General Hospital of P.L.A Beijing 100853, China.The Second Artilery General Hospital of P.L.A Beijing 100853, China.The Experimental Animals Center, 302 Military Hospital of China Beijing 100039, China.International Center for Liver Disease Treatment, 302 Hospital of PLA Beijing 100039, China.Department of Nutrition, Institute of Health and Environmental Medicine Tianjin 300050, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26191155

Citation

Cong, Tao, et al. "Anti-fibrotic Effects of the Masson Pine Pollen Aqueous Extract On Hepatic Fibrosis Rat Model." International Journal of Clinical and Experimental Pathology, vol. 8, no. 5, 2015, pp. 4651-61.
Cong T, Jin XY, Zhao L, et al. Anti-fibrotic effects of the Masson pine pollen aqueous extract on hepatic fibrosis rat model. Int J Clin Exp Pathol. 2015;8(5):4651-61.
Cong, T., Jin, X. Y., Zhao, L., Ma, L., Li, R. S., Zhao, P., & Guo, C. J. (2015). Anti-fibrotic effects of the Masson pine pollen aqueous extract on hepatic fibrosis rat model. International Journal of Clinical and Experimental Pathology, 8(5), 4651-61.
Cong T, et al. Anti-fibrotic Effects of the Masson Pine Pollen Aqueous Extract On Hepatic Fibrosis Rat Model. Int J Clin Exp Pathol. 2015;8(5):4651-61. PubMed PMID: 26191155.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-fibrotic effects of the Masson pine pollen aqueous extract on hepatic fibrosis rat model. AU - Cong,Tao, AU - Jin,Xue-Yuan, AU - Zhao,Lin, AU - Ma,Long, AU - Li,Rui-Sheng, AU - Zhao,Ping, AU - Guo,Chang-Jiang, Y1 - 2015/05/01/ PY - 2015/01/13/received PY - 2015/03/16/accepted PY - 2015/7/21/entrez PY - 2015/7/21/pubmed PY - 2016/4/19/medline KW - CCl4 KW - Masson pine pollen aqueous extract KW - antioxidant KW - hepatic fibrosis KW - matrix metalloproteinase SP - 4651 EP - 61 JF - International journal of clinical and experimental pathology JO - Int J Clin Exp Pathol VL - 8 IS - 5 N2 - AIM: To observe the antifibrotic effects of Masson Pine Pollen aqueous extract. METHODS: Adult Sprague-Dawley rats were randomly divided into control (CG), hepatic fibrosis model (MG), MPPAE low dose (LG), MPPAE high dose (HG), and MPP original powder (MPPOP; OG) groups. Each group was treated with specific protocols and sacrificed 8 weeks later. Multiple indicators such as serum transaminase, HE staining of the liver tissue, and relevant indexes to fibrosis were determined. RESULTS: Severe hyperplasia of fibrous connective tissues was observed in livers of the MG group rats, while aspartate transaminase and alanine transaminase levels and collagen content obviously increased, superoxide dismutase and glutathione peroxidase activities and MMPs expression decreased, malondialdehyde (MDA) and 8-hydroxy-2'-deoxyguanosine concentrations increased, while mRNA expressions of hepatic stellate cell (HSC)-related cytokines such as transforming growth factor-β1 and platelet-derived growth factor, transcription factors such as nuclear factor-κB p65, and signaling protein α-smooth muscle actin were all increased significantly. CONCLUSIONS: MPPAE effectively inhibited the fibrotic process in this CCl4-induced hepatic fibrosis rat model. It may be associated with synergic functions of antioxidant activity, inhibitory activity on HSC proliferation, collagen synthesis, and MMPs expression induction. SN - 1936-2625 UR - https://www.unboundmedicine.com/medline/citation/26191155/Anti_fibrotic_effects_of_the_Masson_pine_pollen_aqueous_extract_on_hepatic_fibrosis_rat_model_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26191155/ DB - PRIME DP - Unbound Medicine ER -