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In vivo induction of antioxidant response and oxidative stress associated with genotoxicity and histopathological alteration in two commercial fish species due to heavy metals exposure in northern India (Kali) river.
Comp Biochem Physiol C Toxicol Pharmacol. 2015 Oct-Nov; 176-177:17-30.CB

Abstract

Heavy metals can significantly bioaccumulate in fish tissues. The step wise mechanism of heavy metal toxicities on fish health is still limited. The present study assessed the tissue-specific antioxidant response and oxidative stress biomarkers of commercially important fish species namely, Channa striatus and Heteropneustes fossilis inhabiting Kali River of northern India where heavy-metal load is beyond the World Health Organisation - maximum permissible limits. Heavy metals chromium (Cr), nickel (Ni), lead (Pb) and cadmium (Cd) were elevated in both fish species compared to recommended values of the Federal Environmental Protection Agency (FEPA), 1999 for edible fishes. Reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CATA) activities in all tissues (brachial, neural, renal and hepatic) were altered. Cellular lipid and protein compromisation in both fishes induced by heavy metals was determined by lipid peroxidation (LPO) and protein carbonylation (PC) assays. Micronucleus (MN) test of erythrocytes and comet assay of liver cells confirmed genotoxicity. Histopathology of the liver, kidney and brain of affected fishes was distorted significantly with its reference fishes thereby affecting the quality and quantity of these fish stocks. This raises a serious concern as these fishes are consumed by the local population which would ultimately affect human health.

Authors+Show Affiliations

Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002 U.P., India; Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim University, Aligarh, India. Electronic address: lifesciencephd@gmail.com.Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002 U.P., India.Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002 U.P., India; Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim University, Aligarh, India.Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim University, Aligarh, India.Department of Biochemistry, Jawaharlal Nehru Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh, India.Department of Pathology, Jawaharlal Nehru Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh, India.Department of Anatomy, Jawaharlal Nehru Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh, India.Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002 U.P., India; Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim University, Aligarh, India.Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim University, Aligarh, India.Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim University, Aligarh, India.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26191657

Citation

Fatima, Mahino, et al. "In Vivo Induction of Antioxidant Response and Oxidative Stress Associated With Genotoxicity and Histopathological Alteration in Two Commercial Fish Species Due to Heavy Metals Exposure in Northern India (Kali) River." Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, vol. 176-177, 2015, pp. 17-30.
Fatima M, Usmani N, Firdaus F, et al. In vivo induction of antioxidant response and oxidative stress associated with genotoxicity and histopathological alteration in two commercial fish species due to heavy metals exposure in northern India (Kali) river. Comp Biochem Physiol C Toxicol Pharmacol. 2015;176-177:17-30.
Fatima, M., Usmani, N., Firdaus, F., Zafeer, M. F., Ahmad, S., Akhtar, K., Dawar Husain, S. M., Ahmad, M. H., Anis, E., & Mobarak Hossain, M. (2015). In vivo induction of antioxidant response and oxidative stress associated with genotoxicity and histopathological alteration in two commercial fish species due to heavy metals exposure in northern India (Kali) river. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, 176-177, 17-30. https://doi.org/10.1016/j.cbpc.2015.07.004
Fatima M, et al. In Vivo Induction of Antioxidant Response and Oxidative Stress Associated With Genotoxicity and Histopathological Alteration in Two Commercial Fish Species Due to Heavy Metals Exposure in Northern India (Kali) River. Comp Biochem Physiol C Toxicol Pharmacol. 2015 Oct-Nov;176-177:17-30. PubMed PMID: 26191657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo induction of antioxidant response and oxidative stress associated with genotoxicity and histopathological alteration in two commercial fish species due to heavy metals exposure in northern India (Kali) river. AU - Fatima,Mahino, AU - Usmani,Nazura, AU - Firdaus,Fakiha, AU - Zafeer,Mohammad Faraz, AU - Ahmad,Shafeeque, AU - Akhtar,Kafil, AU - Dawar Husain,S M, AU - Ahmad,Mir Hilal, AU - Anis,Ehraz, AU - Mobarak Hossain,M, Y1 - 2015/07/17/ PY - 2015/04/14/received PY - 2015/07/03/revised PY - 2015/07/08/accepted PY - 2015/7/21/entrez PY - 2015/7/21/pubmed PY - 2016/6/4/medline KW - Antioxidant response KW - Comet assay (CA) KW - Fishes KW - Heavy metals KW - Histopathology KW - Micronucleus (MN) test SP - 17 EP - 30 JF - Comparative biochemistry and physiology. Toxicology & pharmacology : CBP JO - Comp Biochem Physiol C Toxicol Pharmacol VL - 176-177 N2 - Heavy metals can significantly bioaccumulate in fish tissues. The step wise mechanism of heavy metal toxicities on fish health is still limited. The present study assessed the tissue-specific antioxidant response and oxidative stress biomarkers of commercially important fish species namely, Channa striatus and Heteropneustes fossilis inhabiting Kali River of northern India where heavy-metal load is beyond the World Health Organisation - maximum permissible limits. Heavy metals chromium (Cr), nickel (Ni), lead (Pb) and cadmium (Cd) were elevated in both fish species compared to recommended values of the Federal Environmental Protection Agency (FEPA), 1999 for edible fishes. Reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CATA) activities in all tissues (brachial, neural, renal and hepatic) were altered. Cellular lipid and protein compromisation in both fishes induced by heavy metals was determined by lipid peroxidation (LPO) and protein carbonylation (PC) assays. Micronucleus (MN) test of erythrocytes and comet assay of liver cells confirmed genotoxicity. Histopathology of the liver, kidney and brain of affected fishes was distorted significantly with its reference fishes thereby affecting the quality and quantity of these fish stocks. This raises a serious concern as these fishes are consumed by the local population which would ultimately affect human health. SN - 1532-0456 UR - https://www.unboundmedicine.com/medline/citation/26191657/In_vivo_induction_of_antioxidant_response_and_oxidative_stress_associated_with_genotoxicity_and_histopathological_alteration_in_two_commercial_fish_species_due_to_heavy_metals_exposure_in_northern_India__Kali__river_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1532-0456(15)00078-2 DB - PRIME DP - Unbound Medicine ER -