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Long-term consequences of breastfeeding on cholesterol, obesity, systolic blood pressure and type 2 diabetes: a systematic review and meta-analysis.
Acta Paediatr 2015; 104(467):30-7AP

Abstract

AIM

To systematically review the evidence on the associations between breastfeeding and overweight/obesity, blood pressure, total cholesterol and type 2 diabetes.

METHODS

Two independent literature searches were carried out using the MEDLINE, LILACS, SCIELO and Web of Science databases. Studies restricted to infants and those without an internal comparison group were excluded. Fixed- and random-effects models were used to pool the estimates.

RESULTS

Breastfed subjects were less likely to be considered obese/overweight [pooled odds ratio: 0.74 (95% confidence interval (CI): 0.70; 0.78)] (n = 113). Among the 11 high-quality studies, the association was smaller [pooled odds ratio: 0.87 (95%CI: 0.76; 0.99)]. Total cholesterol (n = 46) was independent of breastfeeding [pooled mean difference: -0.01 mmol/L (95%CI: -0.05; 0.02)]. Systolic blood pressure (n = 43) was lower among breastfed subjects [mean difference: -0.80 (95%CI: -1.17; -0.43)], but no association was observed among larger studies, and for diastolic blood pressure (n = 38) [mean difference: -0.24 (95%CI: -0.50; 0.02)]. For type 2 diabetes (n = 11), the odds ratio was lower among those subjects who had been breastfed [pooled odds ratio: 0.65 (95%CI: 0.49; 0.86)].

CONCLUSION

Breastfeeding decreased the odds of type 2 diabetes and based on high-quality studies, decreased by 13% the odds of overweight/obesity. No associations were found for total cholesterol or blood pressure.

Authors+Show Affiliations

Postgraduate Program in Epidemiology, Universidade Federal de Pelotas, Petolas, Brazil.Postgraduate Program in Epidemiology, Universidade Federal de Pelotas, Petolas, Brazil.Postgraduate Program in Epidemiology, Universidade Federal de Pelotas, Petolas, Brazil.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

26192560

Citation

Horta, Bernardo L., et al. "Long-term Consequences of Breastfeeding On Cholesterol, Obesity, Systolic Blood Pressure and Type 2 Diabetes: a Systematic Review and Meta-analysis." Acta Paediatrica (Oslo, Norway : 1992), vol. 104, no. 467, 2015, pp. 30-7.
Horta BL, Loret de Mola C, Victora CG. Long-term consequences of breastfeeding on cholesterol, obesity, systolic blood pressure and type 2 diabetes: a systematic review and meta-analysis. Acta Paediatr. 2015;104(467):30-7.
Horta, B. L., Loret de Mola, C., & Victora, C. G. (2015). Long-term consequences of breastfeeding on cholesterol, obesity, systolic blood pressure and type 2 diabetes: a systematic review and meta-analysis. Acta Paediatrica (Oslo, Norway : 1992), 104(467), pp. 30-7. doi:10.1111/apa.13133.
Horta BL, Loret de Mola C, Victora CG. Long-term Consequences of Breastfeeding On Cholesterol, Obesity, Systolic Blood Pressure and Type 2 Diabetes: a Systematic Review and Meta-analysis. Acta Paediatr. 2015;104(467):30-7. PubMed PMID: 26192560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term consequences of breastfeeding on cholesterol, obesity, systolic blood pressure and type 2 diabetes: a systematic review and meta-analysis. AU - Horta,Bernardo L, AU - Loret de Mola,Christian, AU - Victora,Cesar G, PY - 2015/05/13/received PY - 2015/06/25/revised PY - 2015/07/14/accepted PY - 2015/7/21/entrez PY - 2015/7/21/pubmed PY - 2016/7/21/medline KW - Blood lipids KW - blood pressure KW - breastfeeding KW - meta-analysis KW - obesity KW - systematic review KW - type 2 diabetes SP - 30 EP - 7 JF - Acta paediatrica (Oslo, Norway : 1992) JO - Acta Paediatr. VL - 104 IS - 467 N2 - AIM: To systematically review the evidence on the associations between breastfeeding and overweight/obesity, blood pressure, total cholesterol and type 2 diabetes. METHODS: Two independent literature searches were carried out using the MEDLINE, LILACS, SCIELO and Web of Science databases. Studies restricted to infants and those without an internal comparison group were excluded. Fixed- and random-effects models were used to pool the estimates. RESULTS: Breastfed subjects were less likely to be considered obese/overweight [pooled odds ratio: 0.74 (95% confidence interval (CI): 0.70; 0.78)] (n = 113). Among the 11 high-quality studies, the association was smaller [pooled odds ratio: 0.87 (95%CI: 0.76; 0.99)]. Total cholesterol (n = 46) was independent of breastfeeding [pooled mean difference: -0.01 mmol/L (95%CI: -0.05; 0.02)]. Systolic blood pressure (n = 43) was lower among breastfed subjects [mean difference: -0.80 (95%CI: -1.17; -0.43)], but no association was observed among larger studies, and for diastolic blood pressure (n = 38) [mean difference: -0.24 (95%CI: -0.50; 0.02)]. For type 2 diabetes (n = 11), the odds ratio was lower among those subjects who had been breastfed [pooled odds ratio: 0.65 (95%CI: 0.49; 0.86)]. CONCLUSION: Breastfeeding decreased the odds of type 2 diabetes and based on high-quality studies, decreased by 13% the odds of overweight/obesity. No associations were found for total cholesterol or blood pressure. SN - 1651-2227 UR - https://www.unboundmedicine.com/medline/citation/26192560/Long_term_consequences_of_breastfeeding_on_cholesterol_obesity_systolic_blood_pressure_and_type_2_diabetes:_a_systematic_review_and_meta_analysis_ L2 - https://doi.org/10.1111/apa.13133 DB - PRIME DP - Unbound Medicine ER -