Tags

Type your tag names separated by a space and hit enter

JMJD3 as an epigenetic regulator in development and disease.
Int J Biochem Cell Biol. 2015 Oct; 67:148-57.IJ

Abstract

Gene expression is epigenetically regulated through DNA methylation and covalent chromatin modifications, such as acetylation, phosphorylation, ubiquitination, sumoylation, and methylation of histones. Histone methylation state is dynamically regulated by different groups of histone methyltransferases and demethylases. The trimethylation of histone 3 (H3K4) at lysine 4 is usually associated with the activation of gene expression, whereas trimethylation of histone 3 at lysine 27 (H3K27) is associated with the repression of gene expression. The polycomb repressive complex contains the H3K27 methyltransferase Ezh2 and controls dimethylation and trimethylation of H3K27 (H3K27me2/3). The Jumonji domain containing-3 (Jmjd3, KDM6B) and ubiquitously transcribed X-chromosome tetratricopeptide repeat protein (UTX, KDM6A) have been identified as H3K27 demethylases that catalyze the demethylation of H3K27me2/3. The role and mechanisms of both JMJD3 and UTX have been extensively studied for their involvement in development, cell plasticity, immune system, neurodegenerative disease, and cancer. In this review, we will focus on recent progresses made on understanding JMJD3 in the regulation of gene expression in development and diseases. This article is part of a Directed Issue entitled: Epigenetics dynamics in development and disease.

Authors+Show Affiliations

Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA.Department of Microbiology and Immunology, Weill Cornell Medical College, Cornell University, 1300 York Avenue, New York, NY 10065, USA.Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA.Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA; Department of Microbiology and Immunology, Weill Cornell Medical College, Cornell University, 1300 York Avenue, New York, NY 10065, USA. Electronic address: rwang3@tmhs.org.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26193001

Citation

Burchfield, Jana S., et al. "JMJD3 as an Epigenetic Regulator in Development and Disease." The International Journal of Biochemistry & Cell Biology, vol. 67, 2015, pp. 148-57.
Burchfield JS, Li Q, Wang HY, et al. JMJD3 as an epigenetic regulator in development and disease. Int J Biochem Cell Biol. 2015;67:148-57.
Burchfield, J. S., Li, Q., Wang, H. Y., & Wang, R. F. (2015). JMJD3 as an epigenetic regulator in development and disease. The International Journal of Biochemistry & Cell Biology, 67, 148-57. https://doi.org/10.1016/j.biocel.2015.07.006
Burchfield JS, et al. JMJD3 as an Epigenetic Regulator in Development and Disease. Int J Biochem Cell Biol. 2015;67:148-57. PubMed PMID: 26193001.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - JMJD3 as an epigenetic regulator in development and disease. AU - Burchfield,Jana S, AU - Li,Qingtian, AU - Wang,Helen Y, AU - Wang,Rong-Fu, Y1 - 2015/07/17/ PY - 2015/04/09/received PY - 2015/07/13/revised PY - 2015/07/15/accepted PY - 2015/7/21/entrez PY - 2015/7/21/pubmed PY - 2016/6/9/medline KW - H3K27 KW - Histone demethylation KW - Jmjd3 KW - Jumonji KW - Utx SP - 148 EP - 57 JF - The international journal of biochemistry & cell biology JO - Int J Biochem Cell Biol VL - 67 N2 - Gene expression is epigenetically regulated through DNA methylation and covalent chromatin modifications, such as acetylation, phosphorylation, ubiquitination, sumoylation, and methylation of histones. Histone methylation state is dynamically regulated by different groups of histone methyltransferases and demethylases. The trimethylation of histone 3 (H3K4) at lysine 4 is usually associated with the activation of gene expression, whereas trimethylation of histone 3 at lysine 27 (H3K27) is associated with the repression of gene expression. The polycomb repressive complex contains the H3K27 methyltransferase Ezh2 and controls dimethylation and trimethylation of H3K27 (H3K27me2/3). The Jumonji domain containing-3 (Jmjd3, KDM6B) and ubiquitously transcribed X-chromosome tetratricopeptide repeat protein (UTX, KDM6A) have been identified as H3K27 demethylases that catalyze the demethylation of H3K27me2/3. The role and mechanisms of both JMJD3 and UTX have been extensively studied for their involvement in development, cell plasticity, immune system, neurodegenerative disease, and cancer. In this review, we will focus on recent progresses made on understanding JMJD3 in the regulation of gene expression in development and diseases. This article is part of a Directed Issue entitled: Epigenetics dynamics in development and disease. SN - 1878-5875 UR - https://www.unboundmedicine.com/medline/citation/26193001/JMJD3_as_an_epigenetic_regulator_in_development_and_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1357-2725(15)00191-0 DB - PRIME DP - Unbound Medicine ER -