Tags

Type your tag names separated by a space and hit enter

Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2.
Alzheimers Dement. 2015 Jul; 11(7):740-56.AD

Abstract

INTRODUCTION

Alzheimer's Disease Neuroimaging Initiative (ADNI) is now in its 10th year. The primary objective of the magnetic resonance imaging (MRI) core of ADNI has been to improve methods for clinical trials in Alzheimer's disease (AD) and related disorders.

METHODS

We review the contributions of the MRI core from present and past cycles of ADNI (ADNI-1, -Grand Opportunity and -2). We also review plans for the future-ADNI-3.

RESULTS

Contributions of the MRI core include creating standardized acquisition protocols and quality control methods; examining the effect of technical features of image acquisition and analysis on outcome metrics; deriving sample size estimates for future trials based on those outcomes; and piloting the potential utility of MR perfusion, diffusion, and functional connectivity measures in multicenter clinical trials.

DISCUSSION

Over the past decade the MRI core of ADNI has fulfilled its mandate of improving methods for clinical trials in AD and will continue to do so in the future.

Links

PMC Free PDF

Authors+Show Affiliations

Jack CR
Department of Radiology, Mayo Clinic, Rochester, MN, USA. Electronic address: jack.clifford@mayo.edu.
Barnes J
Department of Neurodegenerative Disease, Dementia Research Centre, Institute of Neurology, University College London, London, UK.
Bernstein MA
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Borowski BJ
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Brewer J
Department of Neuroscience, University of California at San Diego, La Jolla, CA, USA.
Clegg S
Department of Neurodegenerative Disease, Dementia Research Centre, Institute of Neurology, University College London, London, UK.
Dale AM
Department of Neuroscience, University of California at San Diego, La Jolla, CA, USA.
Carmichael O
Department of Neurology, University of California at Davis, Davis, CA, USA.
Ching C
Department of Neurology, Imaging Genetics Center, Institute for Neuroimaging & Informatics, University of Southern California, Marina del Rey, CA, USA.
DeCarli C
Department of Neurology, University of California at Davis, Davis, CA, USA; Center for Neuroscience, University of California at Davis, Davis, CA, USA.
Desikan RS
Department of Radiology, University of California at San Diego, La Jolla, CA, USA.
Fennema-Notestine C
Department of Radiology, University of California at San Diego, La Jolla, CA, USA; Department of Psychiatry, University of California at San Diego, La Jolla, CA, USA.
Fjell AM
Department of Psychology, University of Oslo, Oslo, Norway.
Fletcher E
Department of Neurology, University of California at Davis, Davis, CA, USA; Center for Neuroscience, University of California at Davis, Davis, CA, USA.
Fox NC
Department of Neurodegenerative Disease, Dementia Research Centre, Institute of Neurology, University College London, London, UK.
Gunter J
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Gutman BA
Department of Neurology, Imaging Genetics Center, Institute for Neuroimaging & Informatics, University of Southern California, Marina del Rey, CA, USA.
Holland D
Department of Neuroscience, University of California at San Diego, La Jolla, CA, USA.
Hua X
Department of Neurology, Imaging Genetics Center, Institute for Neuroimaging & Informatics, University of Southern California, Marina del Rey, CA, USA.
Insel P
Department of Radiology and Biomedical Imaging, Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Kantarci K
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Killiany RJ
Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA.
Krueger G
Siemens Medical Solutions, Boston, MA, USA.
Leung KK
Translational Imaging Group, Centre for Medical Image Computing, University College London, London, United Kingdom.
Mackin S
Department of Radiology and Biomedical Imaging, Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA; Department of Psychiatry, University of California at San Francisco, San Francisco, CA, USA.
Maillard P
Department of Neurology, University of California at Davis, Davis, CA, USA; Center for Neuroscience, University of California at Davis, Davis, CA, USA.
Malone IB
Department of Neurodegenerative Disease, Dementia Research Centre, Institute of Neurology, University College London, London, UK.
Mattsson N
Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden.
McEvoy L
Department of Radiology, University of California at San Diego, La Jolla, CA, USA.
Modat M
Department of Neurodegenerative Disease, Dementia Research Centre, Institute of Neurology, University College London, London, UK; Translational Imaging Group, Centre for Medical Image Computing, University College London, London, United Kingdom.
Mueller S
Department of Radiology and Biomedical Imaging, Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA; Department of Radiology, University of California at San Francisco, San Francisco, CA, USA.
Nosheny R
Department of Radiology and Biomedical Imaging, Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA; Department of Radiology, University of California at San Francisco, San Francisco, CA, USA.
Ourselin S
Department of Neurodegenerative Disease, Dementia Research Centre, Institute of Neurology, University College London, London, UK; Translational Imaging Group, Centre for Medical Image Computing, University College London, London, United Kingdom.
Schuff N
Department of Radiology and Biomedical Imaging, Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA; Department of Radiology, University of California at San Francisco, San Francisco, CA, USA.
Senjem ML
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Simonson A
Department of Radiology and Biomedical Imaging, Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Thompson PM
Department of Neurology, Imaging Genetics Center, Institute for Neuroimaging & Informatics, University of Southern California, Marina del Rey, CA, USA.
Rettmann D
MR Applications and Workflow, GE Healthcare, Rochester, MN, USA.
Vemuri P
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Walhovd K
Department of Psychology, University of Oslo, Oslo, Norway.
Zhao Y
Philips Healthcare, Cleveland, OH, USA.
Zuk S
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Weiner M
Department of Radiology and Biomedical Imaging, Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA; Department of Psychiatry, University of California at San Francisco, San Francisco, CA, USA; Department of Radiology, University of California at San Francisco, San Francisco, CA, USA; Department of Medicine, University of California at San Francisco, San Francisco, CA, USA; Department of Neurology, University of California at San Francisco, San Francisco, CA, USA.

MeSH

Alzheimer DiseaseBiomarkersBrainCognition DisordersHistory, 20th CenturyHistory, 21st CenturyHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingPositron-Emission TomographySpin Labels

Pub Type(s)

Historical Article
Journal Article

Language

eng

PubMed ID

26194310

Citation

Jack, Clifford R., et al. "Magnetic Resonance Imaging in Alzheimer's Disease Neuroimaging Initiative 2." Alzheimer's & Dementia : the Journal of the Alzheimer's Association, vol. 11, no. 7, 2015, pp. 740-56.
Jack CR, Barnes J, Bernstein MA, et al. Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2. Alzheimers Dement. 2015;11(7):740-56.
Jack, C. R., Barnes, J., Bernstein, M. A., Borowski, B. J., Brewer, J., Clegg, S., Dale, A. M., Carmichael, O., Ching, C., DeCarli, C., Desikan, R. S., Fennema-Notestine, C., Fjell, A. M., Fletcher, E., Fox, N. C., Gunter, J., Gutman, B. A., Holland, D., Hua, X., ... Weiner, M. (2015). Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 11(7), 740-56. https://doi.org/10.1016/j.jalz.2015.05.002
Jack CR, et al. Magnetic Resonance Imaging in Alzheimer's Disease Neuroimaging Initiative 2. Alzheimers Dement. 2015;11(7):740-56. PubMed PMID: 26194310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2. AU - Jack,Clifford R,Jr AU - Barnes,Josephine, AU - Bernstein,Matt A, AU - Borowski,Bret J, AU - Brewer,James, AU - Clegg,Shona, AU - Dale,Anders M, AU - Carmichael,Owen, AU - Ching,Christopher, AU - DeCarli,Charles, AU - Desikan,Rahul S, AU - Fennema-Notestine,Christine, AU - Fjell,Anders M, AU - Fletcher,Evan, AU - Fox,Nick C, AU - Gunter,Jeff, AU - Gutman,Boris A, AU - Holland,Dominic, AU - Hua,Xue, AU - Insel,Philip, AU - Kantarci,Kejal, AU - Killiany,Ron J, AU - Krueger,Gunnar, AU - Leung,Kelvin K, AU - Mackin,Scott, AU - Maillard,Pauline, AU - Malone,Ian B, AU - Mattsson,Niklas, AU - McEvoy,Linda, AU - Modat,Marc, AU - Mueller,Susanne, AU - Nosheny,Rachel, AU - Ourselin,Sebastien, AU - Schuff,Norbert, AU - Senjem,Matthew L, AU - Simonson,Alix, AU - Thompson,Paul M, AU - Rettmann,Dan, AU - Vemuri,Prashanthi, AU - Walhovd,Kristine, AU - Zhao,Yansong, AU - Zuk,Samantha, AU - Weiner,Michael, PY - 2015/03/03/received PY - 2015/04/28/revised PY - 2015/05/05/accepted PY - 2015/7/22/entrez PY - 2015/7/22/pubmed PY - 2016/4/12/medline KW - ADNI KW - Alzheimer's Disease Neuroimaging Initiative KW - Alzheimer's disease KW - Diffusion KW - MRI KW - Neuroimaging KW - Perfusion KW - Resting functional MRI SP - 740 EP - 56 JF - Alzheimer's & dementia : the journal of the Alzheimer's Association JO - Alzheimers Dement VL - 11 IS - 7 N2 - INTRODUCTION: Alzheimer's Disease Neuroimaging Initiative (ADNI) is now in its 10th year. The primary objective of the magnetic resonance imaging (MRI) core of ADNI has been to improve methods for clinical trials in Alzheimer's disease (AD) and related disorders. METHODS: We review the contributions of the MRI core from present and past cycles of ADNI (ADNI-1, -Grand Opportunity and -2). We also review plans for the future-ADNI-3. RESULTS: Contributions of the MRI core include creating standardized acquisition protocols and quality control methods; examining the effect of technical features of image acquisition and analysis on outcome metrics; deriving sample size estimates for future trials based on those outcomes; and piloting the potential utility of MR perfusion, diffusion, and functional connectivity measures in multicenter clinical trials. DISCUSSION: Over the past decade the MRI core of ADNI has fulfilled its mandate of improving methods for clinical trials in AD and will continue to do so in the future. SN - 1552-5279 UR - https://www.unboundmedicine.com/medline/citation/26194310/Magnetic_resonance_imaging_in_Alzheimer's_Disease_Neuroimaging_Initiative_2_ DB - PRIME DP - Unbound Medicine ER -