Tags

Type your tag names separated by a space and hit enter

Surgical feasibility and biocompatibility of wide-field dual-array suprachoroidal-transretinal stimulation prosthesis in middle-sized animals.
Graefes Arch Clin Exp Ophthalmol 2016; 254(4):661-73GA

Abstract

PURPOSE

To investigate the safety and efficacy of a newly-developed wide-field dual-array suprachoroidal-transretinal stimulation (STS) prosthesis in middle-sized animals.

METHODS

The prosthesis consisted of two arrays with 50 to 74 electrodes. To test the feasibility of implanting the prosthesis and its efficacy, the prosthesis was implanted for 14 days into two rabbits. Optical coherence tomography (OCT) and ophthalmoscopy were performed 7 and 14 days after the implantation. Then the rabbits were euthanized, eyes were enucleated, and the posterior segment of the eye was examined histologically. In a second experiment, the arrays were implanted into two cats, and their ability to elicit neural responses was determined by electrically evoked potentials (EEPs) at the chiasm and by optical imaging of the retina.

RESULTS

All arrays were successfully implanted, and no major complications occurred during the surgery or during the 2-week postoperative period. Neither OCT nor ophthalmoscopy showed any major complications or instability of the arrays. Histological evaluations showed only mild cellular infiltration and overall good retinal preservation. Stimulation of the retina by the arrays evoked EEPs recorded from the chiasm. Retinal imaging showed that the electrical pulses from the arrays altered the retinal images indicating an activation of retinal neurons. The thresholds were as low as 100 μA for a chiasm response and 300 μA for the retinal imaging.

CONCLUSION

Implantation of a newly-developed dual-array STS prosthesis for 2 weeks in rabbits was feasible surgically, and safe. The results of retinal imaging showed that the dual-array system was able to activate retinal neurons. We conclude that the dual-array design can be implanted without complication and is able to activate retinal neurons and optic nerve axons.

Authors+Show Affiliations

Department of Applied Visual Science, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. Department of Ophthalmology, RWTH Aachen University, Aachen, Germany.Department of Applied Visual Science, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.Department of Applied Visual Science, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.Department of Integrative Physiology, Osaka University Graduate School of Medicine, Osaka, Japan.Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.Department of Ophthalmology, RWTH Aachen University, Aachen, Germany.Department of Applied Visual Science, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. fujikado@ophthal.med.osaka-u.ac.jp.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26194404

Citation

Lohmann, Tibor Karl, et al. "Surgical Feasibility and Biocompatibility of Wide-field Dual-array Suprachoroidal-transretinal Stimulation Prosthesis in Middle-sized Animals." Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, vol. 254, no. 4, 2016, pp. 661-73.
Lohmann TK, Kanda H, Morimoto T, et al. Surgical feasibility and biocompatibility of wide-field dual-array suprachoroidal-transretinal stimulation prosthesis in middle-sized animals. Graefes Arch Clin Exp Ophthalmol. 2016;254(4):661-73.
Lohmann, T. K., Kanda, H., Morimoto, T., Endo, T., Miyoshi, T., Nishida, K., ... Fujikado, T. (2016). Surgical feasibility and biocompatibility of wide-field dual-array suprachoroidal-transretinal stimulation prosthesis in middle-sized animals. Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, 254(4), pp. 661-73. doi:10.1007/s00417-015-3104-1.
Lohmann TK, et al. Surgical Feasibility and Biocompatibility of Wide-field Dual-array Suprachoroidal-transretinal Stimulation Prosthesis in Middle-sized Animals. Graefes Arch Clin Exp Ophthalmol. 2016;254(4):661-73. PubMed PMID: 26194404.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Surgical feasibility and biocompatibility of wide-field dual-array suprachoroidal-transretinal stimulation prosthesis in middle-sized animals. AU - Lohmann,Tibor Karl, AU - Kanda,Hiroyuki, AU - Morimoto,Takeshi, AU - Endo,Takao, AU - Miyoshi,Tomomitsu, AU - Nishida,Kentaro, AU - Kamei,Motohiro, AU - Walter,Peter, AU - Fujikado,Takashi, Y1 - 2015/07/21/ PY - 2015/03/11/received PY - 2015/07/02/accepted PY - 2015/06/24/revised PY - 2015/7/22/entrez PY - 2015/7/22/pubmed PY - 2016/12/15/medline KW - Dual array KW - Retinal implant KW - Retinal prosthesis KW - STS KW - Suprachoroidal–transretinal stimulation SP - 661 EP - 73 JF - Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie JO - Graefes Arch. Clin. Exp. Ophthalmol. VL - 254 IS - 4 N2 - PURPOSE: To investigate the safety and efficacy of a newly-developed wide-field dual-array suprachoroidal-transretinal stimulation (STS) prosthesis in middle-sized animals. METHODS: The prosthesis consisted of two arrays with 50 to 74 electrodes. To test the feasibility of implanting the prosthesis and its efficacy, the prosthesis was implanted for 14 days into two rabbits. Optical coherence tomography (OCT) and ophthalmoscopy were performed 7 and 14 days after the implantation. Then the rabbits were euthanized, eyes were enucleated, and the posterior segment of the eye was examined histologically. In a second experiment, the arrays were implanted into two cats, and their ability to elicit neural responses was determined by electrically evoked potentials (EEPs) at the chiasm and by optical imaging of the retina. RESULTS: All arrays were successfully implanted, and no major complications occurred during the surgery or during the 2-week postoperative period. Neither OCT nor ophthalmoscopy showed any major complications or instability of the arrays. Histological evaluations showed only mild cellular infiltration and overall good retinal preservation. Stimulation of the retina by the arrays evoked EEPs recorded from the chiasm. Retinal imaging showed that the electrical pulses from the arrays altered the retinal images indicating an activation of retinal neurons. The thresholds were as low as 100 μA for a chiasm response and 300 μA for the retinal imaging. CONCLUSION: Implantation of a newly-developed dual-array STS prosthesis for 2 weeks in rabbits was feasible surgically, and safe. The results of retinal imaging showed that the dual-array system was able to activate retinal neurons. We conclude that the dual-array design can be implanted without complication and is able to activate retinal neurons and optic nerve axons. SN - 1435-702X UR - https://www.unboundmedicine.com/medline/citation/26194404/Surgical_feasibility_and_biocompatibility_of_wide_field_dual_array_suprachoroidal_transretinal_stimulation_prosthesis_in_middle_sized_animals_ L2 - https://dx.doi.org/10.1007/s00417-015-3104-1 DB - PRIME DP - Unbound Medicine ER -