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Exposure to Bisphenol A and Phthalates during Pregnancy and Ultrasound Measures of Fetal Growth in the INMA-Sabadell Cohort.
Environ Health Perspect. 2016 Apr; 124(4):521-8.EH

Abstract

BACKGROUND

Prenatal exposure to bisphenol A (BPA) and phthalates may affect fetal growth; however, previous findings are inconsistent and based on few studies.

OBJECTIVES

We assessed whether prenatal exposure to BPA and phthalates was associated with fetal growth in a Spanish birth cohort of 488 mother-child pairs.

METHODS

We measured BPA and eight phthalates [four di(2-ethylhexyl) phthalate metabolites (DEHPm), mono-benzyl phthalate (MBzP), and three low-molecular-weight phthalate metabolites (LMWPm)] in two spot-urine samples collected during the first and third trimester of pregnancy. We estimated growth curves for femur length (FL), head circumference (HC), abdominal circumference (AC), biparietal diameter (BPD), and estimated fetal weight (EFW) during pregnancy (weeks 12-20 and 20-34), and for birth weight, birth length, head circumference at birth, and placental weight.

RESULTS

Overall, results did not support associations of exposure to BPA or DEHPm during pregnancy with fetal growth parameters. Prenatal MBzP exposure was positively associated with FL at 20-34 weeks, resulting in an increase of 3.70% of the average FL (95% CI: 0.75, 6.63%) per doubling of MBzP concentration. MBzP was positively associated with birth weight among boys (48 g; 95% CI: 6, 90) but not in girls (-27 g; 95% CI: -79, 25) (interaction p-value = 0.04). The LMWPm mono-n-butyl phthalate (MnBP) was negatively associated with HC at 12-20 pregnancy weeks [-4.88% of HC average (95% CI: -8.36, -1.36%)].

CONCLUSIONS

This study, one of the first to combine repeat exposure biomarker measurements and multiple growth measures during pregnancy, finds little evidence of associations of BPA or phthalate exposures with fetal growth. Phthalate metabolites MBzP and MnBP were associated with some fetal growth parameters, but these findings require replication.

CITATION

Casas M, Valvi D, Ballesteros-Gomez A, Gascon M, Fernández MF, Garcia-Esteban R, Iñiguez C, Martínez D, Murcia M, Monfort N, Luque N, Rubio S, Ventura R, Sunyer J, Vrijheid M. 2016. Exposure to bisphenol A and phthalates during pregnancy and ultrasound measures of fetal growth in the INMA-Sabadell cohort. Environ Health Perspect 124:521-528; http://dx.doi.org/10.1289/ehp.1409190.

Links

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Authors+Show Affiliations

Casas M
Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
Valvi D
No affiliation info available
Ballesteros-Gomez A
No affiliation info available
Gascon M
No affiliation info available
Fernández MF
No affiliation info available
Garcia-Esteban R
No affiliation info available
Iñiguez C
No affiliation info available
Martínez D
No affiliation info available
Murcia M
No affiliation info available
Monfort N
No affiliation info available
Luque N
No affiliation info available
Rubio S
No affiliation info available
Ventura R
No affiliation info available
Sunyer J
No affiliation info available
Vrijheid M
No affiliation info available

MeSH

AdolescentAdultBenzhydryl CompoundsBirth WeightCohort StudiesEnvironmental ExposureFemaleFetal DevelopmentHumansInfant, NewbornMaleMaternal ExposureMaternal-Fetal ExchangePhenolsPhthalic AcidsPregnancySpainUltrasonography, Prenatal

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26196298

Citation

Casas, Maribel, et al. "Exposure to Bisphenol a and Phthalates During Pregnancy and Ultrasound Measures of Fetal Growth in the INMA-Sabadell Cohort." Environmental Health Perspectives, vol. 124, no. 4, 2016, pp. 521-8.
Casas M, Valvi D, Ballesteros-Gomez A, et al. Exposure to Bisphenol A and Phthalates during Pregnancy and Ultrasound Measures of Fetal Growth in the INMA-Sabadell Cohort. Environ Health Perspect. 2016;124(4):521-8.
Casas, M., Valvi, D., Ballesteros-Gomez, A., Gascon, M., Fernández, M. F., Garcia-Esteban, R., Iñiguez, C., Martínez, D., Murcia, M., Monfort, N., Luque, N., Rubio, S., Ventura, R., Sunyer, J., & Vrijheid, M. (2016). Exposure to Bisphenol A and Phthalates during Pregnancy and Ultrasound Measures of Fetal Growth in the INMA-Sabadell Cohort. Environmental Health Perspectives, 124(4), 521-8. https://doi.org/10.1289/ehp.1409190
Casas M, et al. Exposure to Bisphenol a and Phthalates During Pregnancy and Ultrasound Measures of Fetal Growth in the INMA-Sabadell Cohort. Environ Health Perspect. 2016;124(4):521-8. PubMed PMID: 26196298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exposure to Bisphenol A and Phthalates during Pregnancy and Ultrasound Measures of Fetal Growth in the INMA-Sabadell Cohort. AU - Casas,Maribel, AU - Valvi,Damaskini, AU - Ballesteros-Gomez,Ana, AU - Gascon,Mireia, AU - Fernández,Mariana F, AU - Garcia-Esteban,Raquel, AU - Iñiguez,Carmen, AU - Martínez,David, AU - Murcia,Mario, AU - Monfort,Nuria, AU - Luque,Noelia, AU - Rubio,Soledad, AU - Ventura,Rosa, AU - Sunyer,Jordi, AU - Vrijheid,Martine, Y1 - 2015/07/21/ PY - 2014/09/08/received PY - 2015/07/17/accepted PY - 2015/7/22/entrez PY - 2015/7/22/pubmed PY - 2017/1/25/medline SP - 521 EP - 8 JF - Environmental health perspectives JO - Environ Health Perspect VL - 124 IS - 4 N2 - BACKGROUND: Prenatal exposure to bisphenol A (BPA) and phthalates may affect fetal growth; however, previous findings are inconsistent and based on few studies. OBJECTIVES: We assessed whether prenatal exposure to BPA and phthalates was associated with fetal growth in a Spanish birth cohort of 488 mother-child pairs. METHODS: We measured BPA and eight phthalates [four di(2-ethylhexyl) phthalate metabolites (DEHPm), mono-benzyl phthalate (MBzP), and three low-molecular-weight phthalate metabolites (LMWPm)] in two spot-urine samples collected during the first and third trimester of pregnancy. We estimated growth curves for femur length (FL), head circumference (HC), abdominal circumference (AC), biparietal diameter (BPD), and estimated fetal weight (EFW) during pregnancy (weeks 12-20 and 20-34), and for birth weight, birth length, head circumference at birth, and placental weight. RESULTS: Overall, results did not support associations of exposure to BPA or DEHPm during pregnancy with fetal growth parameters. Prenatal MBzP exposure was positively associated with FL at 20-34 weeks, resulting in an increase of 3.70% of the average FL (95% CI: 0.75, 6.63%) per doubling of MBzP concentration. MBzP was positively associated with birth weight among boys (48 g; 95% CI: 6, 90) but not in girls (-27 g; 95% CI: -79, 25) (interaction p-value = 0.04). The LMWPm mono-n-butyl phthalate (MnBP) was negatively associated with HC at 12-20 pregnancy weeks [-4.88% of HC average (95% CI: -8.36, -1.36%)]. CONCLUSIONS: This study, one of the first to combine repeat exposure biomarker measurements and multiple growth measures during pregnancy, finds little evidence of associations of BPA or phthalate exposures with fetal growth. Phthalate metabolites MBzP and MnBP were associated with some fetal growth parameters, but these findings require replication. CITATION: Casas M, Valvi D, Ballesteros-Gomez A, Gascon M, Fernández MF, Garcia-Esteban R, Iñiguez C, Martínez D, Murcia M, Monfort N, Luque N, Rubio S, Ventura R, Sunyer J, Vrijheid M. 2016. Exposure to bisphenol A and phthalates during pregnancy and ultrasound measures of fetal growth in the INMA-Sabadell cohort. Environ Health Perspect 124:521-528; http://dx.doi.org/10.1289/ehp.1409190. SN - 1552-9924 UR - https://www.unboundmedicine.com/medline/citation/26196298/Exposure_to_Bisphenol_A_and_Phthalates_during_Pregnancy_and_Ultrasound_Measures_of_Fetal_Growth_in_the_INMA_Sabadell_Cohort_ DB - PRIME DP - Unbound Medicine ER -