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Effect of Non-psychotropic Plant-derived Cannabinoids on Bladder Contractility: Focus on Cannabigerol.
Nat Prod Commun 2015; 10(6):1009-12NP

Abstract

There are anecdotal reports that some Cannabis preparations may be useful for bladder dysfunctions. Here, we investigated the effect of a number of non- psychotropic phytocannabinoids, namely cannabidiol (CBD), cannabigerol (CBG), cannabidivarin (CBDV), Δ9-tetrahydrocannabivarin (THCV) and cannabichromene (CBC) on mouse bladder contractility in vitro. CBG, THCV, CBD and CBDV, but not CBC, at concentration ranging from 10(-8) M to 10(-4) M, decreased (with similar potency), the contractions induced by acetylcholine without significantly modifying the contractions induced by electrical stimulation. The rank order of efficacy was CBG=THCV>CBD>CBDV. In depth studies on CBG showed that the effect of this phytocannabinoid on acetylcholine-induced contractions was not affected by CB1 or CB2 receptor antagonists. Additionally, CBG also reduced acetylcholine-induced contractions in the human bladder.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

26197538

Citation

Pagano, Ester, et al. "Effect of Non-psychotropic Plant-derived Cannabinoids On Bladder Contractility: Focus On Cannabigerol." Natural Product Communications, vol. 10, no. 6, 2015, pp. 1009-12.
Pagano E, Montanaro V, Di Girolamo A, et al. Effect of Non-psychotropic Plant-derived Cannabinoids on Bladder Contractility: Focus on Cannabigerol. Nat Prod Commun. 2015;10(6):1009-12.
Pagano, E., Montanaro, V., Di Girolamo, A., Pistone, A., Altieri, V., Zjawiony, J. K., ... Capasso, R. (2015). Effect of Non-psychotropic Plant-derived Cannabinoids on Bladder Contractility: Focus on Cannabigerol. Natural Product Communications, 10(6), pp. 1009-12.
Pagano E, et al. Effect of Non-psychotropic Plant-derived Cannabinoids On Bladder Contractility: Focus On Cannabigerol. Nat Prod Commun. 2015;10(6):1009-12. PubMed PMID: 26197538.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Non-psychotropic Plant-derived Cannabinoids on Bladder Contractility: Focus on Cannabigerol. AU - Pagano,Ester, AU - Montanaro,Vittorino, AU - Di Girolamo,Antonio, AU - Pistone,Antonio, AU - Altieri,Vincenzo, AU - Zjawiony,Jordan K, AU - Izzo,Angelo A, AU - Capasso,Raffaele, PY - 2015/7/23/entrez PY - 2015/7/23/pubmed PY - 2015/8/22/medline SP - 1009 EP - 12 JF - Natural product communications JO - Nat Prod Commun VL - 10 IS - 6 N2 - There are anecdotal reports that some Cannabis preparations may be useful for bladder dysfunctions. Here, we investigated the effect of a number of non- psychotropic phytocannabinoids, namely cannabidiol (CBD), cannabigerol (CBG), cannabidivarin (CBDV), Δ9-tetrahydrocannabivarin (THCV) and cannabichromene (CBC) on mouse bladder contractility in vitro. CBG, THCV, CBD and CBDV, but not CBC, at concentration ranging from 10(-8) M to 10(-4) M, decreased (with similar potency), the contractions induced by acetylcholine without significantly modifying the contractions induced by electrical stimulation. The rank order of efficacy was CBG=THCV>CBD>CBDV. In depth studies on CBG showed that the effect of this phytocannabinoid on acetylcholine-induced contractions was not affected by CB1 or CB2 receptor antagonists. Additionally, CBG also reduced acetylcholine-induced contractions in the human bladder. SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/26197538/Effect_of_Non_psychotropic_Plant_derived_Cannabinoids_on_Bladder_Contractility:_Focus_on_Cannabigerol_ DB - PRIME DP - Unbound Medicine ER -