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Chemoinformatics Approach to Antibacterial Studies of Essential Oils.
Nat Prod Commun. 2015 Jun; 10(6):1063-6.NP

Abstract

The chemical composition and antibacterial activity of Nepeta nuda (Lamiaceae) essential oil were examined, as well as the association between it and standard antibiotics: tetracycline and streptomycin. The antibacterial activities of 1,8-cineole, the main constituent of N. nuda oil, individually and in combination with standard antibiotics were also determined. The interactions of the essential oil and 1,8-cineole with antibiotics toward five selected strains were evaluated using the microdilution checkerboard assay in combination with chemoinformatics methods. Oxygenated monoterpenes were the most abundant compound class in the oil (57.8%), with 1,8-cineole (46.0%) as the major compound. The essential oil exhibited in vitro antibacterial activity against all tested bacterial strains, but the activities were lower than those of the standard antibiotics. The combinations N. nuda oil-antibiotic and 1,8-cineole-antibiotic produced a predominantly antagonistic interactions. Chemoinformatics survey confirms the antagonistic interactions as a consequence of membrane potential/proton motive force dissipation. These data indicate cytochrome c oxidase as a target for 1.8-cineole toxicity action mechanisms.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26197552

Citation

Miladinović, Dragoljub L., et al. "Chemoinformatics Approach to Antibacterial Studies of Essential Oils." Natural Product Communications, vol. 10, no. 6, 2015, pp. 1063-6.
Miladinović DL, Ilić BS, Kocić BD. Chemoinformatics Approach to Antibacterial Studies of Essential Oils. Nat Prod Commun. 2015;10(6):1063-6.
Miladinović, D. L., Ilić, B. S., & Kocić, B. D. (2015). Chemoinformatics Approach to Antibacterial Studies of Essential Oils. Natural Product Communications, 10(6), 1063-6.
Miladinović DL, Ilić BS, Kocić BD. Chemoinformatics Approach to Antibacterial Studies of Essential Oils. Nat Prod Commun. 2015;10(6):1063-6. PubMed PMID: 26197552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemoinformatics Approach to Antibacterial Studies of Essential Oils. AU - Miladinović,Dragoljub L, AU - Ilić,Budimir S, AU - Kocić,Branislava D, PY - 2015/7/23/entrez PY - 2015/7/23/pubmed PY - 2015/8/22/medline SP - 1063 EP - 6 JF - Natural product communications JO - Nat Prod Commun VL - 10 IS - 6 N2 - The chemical composition and antibacterial activity of Nepeta nuda (Lamiaceae) essential oil were examined, as well as the association between it and standard antibiotics: tetracycline and streptomycin. The antibacterial activities of 1,8-cineole, the main constituent of N. nuda oil, individually and in combination with standard antibiotics were also determined. The interactions of the essential oil and 1,8-cineole with antibiotics toward five selected strains were evaluated using the microdilution checkerboard assay in combination with chemoinformatics methods. Oxygenated monoterpenes were the most abundant compound class in the oil (57.8%), with 1,8-cineole (46.0%) as the major compound. The essential oil exhibited in vitro antibacterial activity against all tested bacterial strains, but the activities were lower than those of the standard antibiotics. The combinations N. nuda oil-antibiotic and 1,8-cineole-antibiotic produced a predominantly antagonistic interactions. Chemoinformatics survey confirms the antagonistic interactions as a consequence of membrane potential/proton motive force dissipation. These data indicate cytochrome c oxidase as a target for 1.8-cineole toxicity action mechanisms. SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/26197552/Chemoinformatics_Approach_to_Antibacterial_Studies_of_Essential_Oils_ L2 - https://medlineplus.gov/antibiotics.html DB - PRIME DP - Unbound Medicine ER -