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STR allele sequence variation: Current knowledge and future issues.
Forensic Sci Int Genet. 2015 Sep; 18:118-30.FS

Abstract

This article reviews what is currently known about short tandem repeat (STR) allelic sequence variation in and around the twenty-four loci most commonly used throughout the world to perform forensic DNA investigations. These STR loci include D1S1656, TPOX, D2S441, D2S1338, D3S1358, FGA, CSF1PO, D5S818, SE33, D6S1043, D7S820, D8S1179, D10S1248, TH01, vWA, D12S391, D13S317, Penta E, D16S539, D18S51, D19S433, D21S11, Penta D, and D22S1045. All known reported variant alleles are compiled along with genomic information available from GenBank, dbSNP, and the 1000 Genomes Project. Supplementary files are included which provide annotated reference sequences for each STR locus, characterize genomic variation around the STR repeat region, and compare alleles present in currently available STR kit allelic ladders. Looking to the future, STR allele nomenclature options are discussed as they relate to next generation sequencing efforts underway.

Authors+Show Affiliations

U.S National Institute of Standards and Technology, Biomolecular Measurement Division, 100 Bureau Drive, Gaithersburg, MD 20899, USA. Electronic address: katherine.gettings@nist.gov.The George Washington University, Department of Forensic Sciences, 2100 Foxhall Road NW, Washington, DC 20007, USA. Electronic address: raponte@gwu.edu.U.S National Institute of Standards and Technology, Biomolecular Measurement Division, 100 Bureau Drive, Gaithersburg, MD 20899, USA. Electronic address: peter.vallone@nist.gov.U.S. National Institute of Standards and Technology, Special Programs Office, 100 Bureau Drive, Gaithersburg, MD 20899, USA. Electronic address: john.butler@nist.gov.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

26197946

Citation

Gettings, Katherine Butler, et al. "STR Allele Sequence Variation: Current Knowledge and Future Issues." Forensic Science International. Genetics, vol. 18, 2015, pp. 118-30.
Gettings KB, Aponte RA, Vallone PM, et al. STR allele sequence variation: Current knowledge and future issues. Forensic Sci Int Genet. 2015;18:118-30.
Gettings, K. B., Aponte, R. A., Vallone, P. M., & Butler, J. M. (2015). STR allele sequence variation: Current knowledge and future issues. Forensic Science International. Genetics, 18, 118-30. https://doi.org/10.1016/j.fsigen.2015.06.005
Gettings KB, et al. STR Allele Sequence Variation: Current Knowledge and Future Issues. Forensic Sci Int Genet. 2015;18:118-30. PubMed PMID: 26197946.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - STR allele sequence variation: Current knowledge and future issues. AU - Gettings,Katherine Butler, AU - Aponte,Rachel A, AU - Vallone,Peter M, AU - Butler,John M, Y1 - 2015/07/06/ PY - 2015/02/13/received PY - 2015/05/20/revised PY - 2015/06/10/accepted PY - 2015/7/23/entrez PY - 2015/7/23/pubmed PY - 2016/6/3/medline KW - DNA database KW - Forensic DNA KW - STR loci KW - STR nomenclature KW - Sequence variation KW - Short tandem repeat SP - 118 EP - 30 JF - Forensic science international. Genetics JO - Forensic Sci Int Genet VL - 18 N2 - This article reviews what is currently known about short tandem repeat (STR) allelic sequence variation in and around the twenty-four loci most commonly used throughout the world to perform forensic DNA investigations. These STR loci include D1S1656, TPOX, D2S441, D2S1338, D3S1358, FGA, CSF1PO, D5S818, SE33, D6S1043, D7S820, D8S1179, D10S1248, TH01, vWA, D12S391, D13S317, Penta E, D16S539, D18S51, D19S433, D21S11, Penta D, and D22S1045. All known reported variant alleles are compiled along with genomic information available from GenBank, dbSNP, and the 1000 Genomes Project. Supplementary files are included which provide annotated reference sequences for each STR locus, characterize genomic variation around the STR repeat region, and compare alleles present in currently available STR kit allelic ladders. Looking to the future, STR allele nomenclature options are discussed as they relate to next generation sequencing efforts underway. SN - 1878-0326 UR - https://www.unboundmedicine.com/medline/citation/26197946/STR_allele_sequence_variation:_Current_knowledge_and_future_issues_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1872-4973(15)30026-0 DB - PRIME DP - Unbound Medicine ER -