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Probiotics for prevention of atopic diseases in infants: systematic review and meta-analysis.
Allergy. 2015 Nov; 70(11):1356-71.A

Abstract

Growing evidence underlines the pivotal role of infant gut colonization in the development of the immune system. The possibility to modify gut colonization through probiotic supplementation in childhood might prevent atopic diseases. The aim of the present systematic review and meta-analysis was to evaluate the effect of probiotic supplementation during pregnancy and early infancy in preventing atopic diseases. PubMed, Embase and Cochrane Library were searched for randomized controlled trials evaluating the use of probiotics during pregnancy or early infancy for prevention of allergic diseases. Fixed-effect models were used, and random-effects models where significant heterogeneity was present. Results were expressed as risk ratio (RR) with 95% confidence interval (CI). Seventeen studies, reporting data from 4755 children (2381 in the probiotic group and 2374 in the control group), were included in the meta-analysis. Infants treated with probiotics had a significantly lower RR for eczema compared to controls (RR 0.78 [95% CI: 0.69-0.89], P = 0.0003), especially those supplemented with a mixture of probiotics (RR 0.54 [95% CI: 0.43-0.68], P < 0.00001). No significant difference in terms of prevention of asthma (RR 0.99 [95% CI: 0.77-1.27], P = 0.95), wheezing (RR 1.02 [95% CI: 0.89-1.17], P = 0.76) or rhinoconjunctivitis (RR 0.91 [95% CI: 0.67-1.23], P = 0.53) was documented. The results of the present meta-analysis show that probiotic supplementation prevents infantile eczema, thus suggesting a new potential indication for probiotic use in pregnancy and infancy.

Authors+Show Affiliations

Department of Pediatrics, Children Hospital V. Buzzi, University of Milan, Milan, Italy.Department of Pediatrics, L. Sacco Hospital, University of Milan, Milan, Italy.Neonatology and Neonatal Intensive Care Unit, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.Neonatal Unit, Catholic University, Rome, Italy.Institute of Microbiology, UCSC, Piacenza, Italy.Department of Pediatrics, Aldo Moro University, Bari, Italy.Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.Department of Pediatrics, Aldo Moro University, Bari, Italy.Neonatal Unit, Catholic University, Rome, Italy.Institute of Microbiology, UCSC, Piacenza, Italy.Neonatology and Neonatal Intensive Care Unit, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.No affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

26198702

Citation

Zuccotti, G, et al. "Probiotics for Prevention of Atopic Diseases in Infants: Systematic Review and Meta-analysis." Allergy, vol. 70, no. 11, 2015, pp. 1356-71.
Zuccotti G, Meneghin F, Aceti A, et al. Probiotics for prevention of atopic diseases in infants: systematic review and meta-analysis. Allergy. 2015;70(11):1356-71.
Zuccotti, G., Meneghin, F., Aceti, A., Barone, G., Callegari, M. L., Di Mauro, A., Fantini, M. P., Gori, D., Indrio, F., Maggio, L., Morelli, L., & Corvaglia, L. (2015). Probiotics for prevention of atopic diseases in infants: systematic review and meta-analysis. Allergy, 70(11), 1356-71. https://doi.org/10.1111/all.12700
Zuccotti G, et al. Probiotics for Prevention of Atopic Diseases in Infants: Systematic Review and Meta-analysis. Allergy. 2015;70(11):1356-71. PubMed PMID: 26198702.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Probiotics for prevention of atopic diseases in infants: systematic review and meta-analysis. AU - Zuccotti,G, AU - Meneghin,F, AU - Aceti,A, AU - Barone,G, AU - Callegari,M L, AU - Di Mauro,A, AU - Fantini,M P, AU - Gori,D, AU - Indrio,F, AU - Maggio,L, AU - Morelli,L, AU - Corvaglia,L, AU - ,, Y1 - 2015/08/13/ PY - 2015/07/17/accepted PY - 2015/7/23/entrez PY - 2015/7/23/pubmed PY - 2016/8/4/medline KW - atopic diseases KW - infant KW - meta-analysis KW - probiotic SP - 1356 EP - 71 JF - Allergy JO - Allergy VL - 70 IS - 11 N2 - Growing evidence underlines the pivotal role of infant gut colonization in the development of the immune system. The possibility to modify gut colonization through probiotic supplementation in childhood might prevent atopic diseases. The aim of the present systematic review and meta-analysis was to evaluate the effect of probiotic supplementation during pregnancy and early infancy in preventing atopic diseases. PubMed, Embase and Cochrane Library were searched for randomized controlled trials evaluating the use of probiotics during pregnancy or early infancy for prevention of allergic diseases. Fixed-effect models were used, and random-effects models where significant heterogeneity was present. Results were expressed as risk ratio (RR) with 95% confidence interval (CI). Seventeen studies, reporting data from 4755 children (2381 in the probiotic group and 2374 in the control group), were included in the meta-analysis. Infants treated with probiotics had a significantly lower RR for eczema compared to controls (RR 0.78 [95% CI: 0.69-0.89], P = 0.0003), especially those supplemented with a mixture of probiotics (RR 0.54 [95% CI: 0.43-0.68], P < 0.00001). No significant difference in terms of prevention of asthma (RR 0.99 [95% CI: 0.77-1.27], P = 0.95), wheezing (RR 1.02 [95% CI: 0.89-1.17], P = 0.76) or rhinoconjunctivitis (RR 0.91 [95% CI: 0.67-1.23], P = 0.53) was documented. The results of the present meta-analysis show that probiotic supplementation prevents infantile eczema, thus suggesting a new potential indication for probiotic use in pregnancy and infancy. SN - 1398-9995 UR - https://www.unboundmedicine.com/medline/citation/26198702/Probiotics_for_prevention_of_atopic_diseases_in_infants:_systematic_review_and_meta_analysis_ L2 - https://doi.org/10.1111/all.12700 DB - PRIME DP - Unbound Medicine ER -