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A new red cell discriminant incorporating volume dispersion for differentiating iron deficiency anemia from thalassemia minor.
Blood Cells 1989; 15(3):481-91; discussion 492-5BC

Abstract

A novel red cell discriminant function [MCV2 x RDW/(Hgb x 100)] was compared to six other discriminants in 102 patients with established mild iron deficiency anemia and 33 patients with beta-thalassemia minor. The discriminant incorporates the two key measurements of erythrocyte cell volume distribution, namely the mean (MCV) and standard deviation (RDW), which are known to be helpful for distinguishing between these two frequent causes of microcytic hypochromic anemia. Data used for the learning set to develop the new discriminant were obtained using an electrical impedance automated whole blood analyzer (Coulter S + IV) and were applied as a validation set for six other discriminants. The discriminant was also tested on smaller subsets of the patients groups using data obtained on either an alternate electrical impedance instrument (Sysmex E-5000) or a laser light scattering based system (Technicon H*1). From the comparison it was concluded that use of a discriminant function that incorporates a measurement of red cell volume dispersion results in enhanced accuracy for distinguishing iron deficiency anemia from thalassemia minor.

Authors+Show Affiliations

Department of Laboratory Hematology, Cleveland Clinic Foundation, Ohio 44195-5139.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2620095

Citation

Green, R, and R King. "A New Red Cell Discriminant Incorporating Volume Dispersion for Differentiating Iron Deficiency Anemia From Thalassemia Minor." Blood Cells, vol. 15, no. 3, 1989, pp. 481-91; discussion 492-5.
Green R, King R. A new red cell discriminant incorporating volume dispersion for differentiating iron deficiency anemia from thalassemia minor. Blood Cells. 1989;15(3):481-91; discussion 492-5.
Green, R., & King, R. (1989). A new red cell discriminant incorporating volume dispersion for differentiating iron deficiency anemia from thalassemia minor. Blood Cells, 15(3), pp. 481-91; discussion 492-5.
Green R, King R. A New Red Cell Discriminant Incorporating Volume Dispersion for Differentiating Iron Deficiency Anemia From Thalassemia Minor. Blood Cells. 1989;15(3):481-91; discussion 492-5. PubMed PMID: 2620095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A new red cell discriminant incorporating volume dispersion for differentiating iron deficiency anemia from thalassemia minor. AU - Green,R, AU - King,R, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 481-91; discussion 492-5 JF - Blood cells JO - Blood Cells VL - 15 IS - 3 N2 - A novel red cell discriminant function [MCV2 x RDW/(Hgb x 100)] was compared to six other discriminants in 102 patients with established mild iron deficiency anemia and 33 patients with beta-thalassemia minor. The discriminant incorporates the two key measurements of erythrocyte cell volume distribution, namely the mean (MCV) and standard deviation (RDW), which are known to be helpful for distinguishing between these two frequent causes of microcytic hypochromic anemia. Data used for the learning set to develop the new discriminant were obtained using an electrical impedance automated whole blood analyzer (Coulter S + IV) and were applied as a validation set for six other discriminants. The discriminant was also tested on smaller subsets of the patients groups using data obtained on either an alternate electrical impedance instrument (Sysmex E-5000) or a laser light scattering based system (Technicon H*1). From the comparison it was concluded that use of a discriminant function that incorporates a measurement of red cell volume dispersion results in enhanced accuracy for distinguishing iron deficiency anemia from thalassemia minor. SN - 0340-4684 UR - https://www.unboundmedicine.com/medline/citation/2620095/A_new_red_cell_discriminant_incorporating_volume_dispersion_for_differentiating_iron_deficiency_anemia_from_thalassemia_minor_ L2 - http://www.diseaseinfosearch.org/result/3873 DB - PRIME DP - Unbound Medicine ER -