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The therapeutic potential of antibiotics and probiotics in the treatment of pouchitis.
Expert Rev Gastroenterol Hepatol. 2015; 9(9):1175-81.ER

Abstract

Pouchitis is the most frequent long-term complication of pouch surgery for ulcerative colitis. There is consistent evidence on the implication of bacterial flora in the pathogenesis of pouchitis, and there is evidence for a therapeutic role of antibiotics and probiotics in therapy of this disease. Antibiotics, particularly ciprofloxacin and metronidazole, are the mainstay of treatment for acute pouchitis. In chronic refractory pouchitis, after having excluded other diagnoses (infections, Crohn's disease of the pouch, ischemia and irritable pouch), antibiotic combination therapy is the treatment of choice. The highly concentrated probiotic mixture VSL#3 has been shown to be effective in prevention of pouchitis onset and in maintaining antibiotic-induced remission.

Authors+Show Affiliations

a Department of Medical and Surgical Sciences (DIMEC), University of Bologna-Italy, Bologna, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26202437

Citation

Gionchetti, Paolo, et al. "The Therapeutic Potential of Antibiotics and Probiotics in the Treatment of Pouchitis." Expert Review of Gastroenterology & Hepatology, vol. 9, no. 9, 2015, pp. 1175-81.
Gionchetti P, Calabrese C, Lauri A, et al. The therapeutic potential of antibiotics and probiotics in the treatment of pouchitis. Expert Rev Gastroenterol Hepatol. 2015;9(9):1175-81.
Gionchetti, P., Calabrese, C., Lauri, A., & Rizzello, F. (2015). The therapeutic potential of antibiotics and probiotics in the treatment of pouchitis. Expert Review of Gastroenterology & Hepatology, 9(9), 1175-81. https://doi.org/10.1586/17474124.2015.1072046
Gionchetti P, et al. The Therapeutic Potential of Antibiotics and Probiotics in the Treatment of Pouchitis. Expert Rev Gastroenterol Hepatol. 2015;9(9):1175-81. PubMed PMID: 26202437.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The therapeutic potential of antibiotics and probiotics in the treatment of pouchitis. AU - Gionchetti,Paolo, AU - Calabrese,Carlo, AU - Lauri,Adriano, AU - Rizzello,Fernando, Y1 - 2015/07/25/ PY - 2015/7/24/entrez PY - 2015/7/24/pubmed PY - 2016/5/21/medline KW - Ileal-pouch anal anastomosis KW - VSL#3 KW - chronic pouchitis KW - ciprofloxacin KW - metronidazole KW - pouchitis KW - probiotics SP - 1175 EP - 81 JF - Expert review of gastroenterology & hepatology JO - Expert Rev Gastroenterol Hepatol VL - 9 IS - 9 N2 - Pouchitis is the most frequent long-term complication of pouch surgery for ulcerative colitis. There is consistent evidence on the implication of bacterial flora in the pathogenesis of pouchitis, and there is evidence for a therapeutic role of antibiotics and probiotics in therapy of this disease. Antibiotics, particularly ciprofloxacin and metronidazole, are the mainstay of treatment for acute pouchitis. In chronic refractory pouchitis, after having excluded other diagnoses (infections, Crohn's disease of the pouch, ischemia and irritable pouch), antibiotic combination therapy is the treatment of choice. The highly concentrated probiotic mixture VSL#3 has been shown to be effective in prevention of pouchitis onset and in maintaining antibiotic-induced remission. SN - 1747-4132 UR - https://www.unboundmedicine.com/medline/citation/26202437/The_therapeutic_potential_of_antibiotics_and_probiotics_in_the_treatment_of_pouchitis_ L2 - http://www.tandfonline.com/doi/full/10.1586/17474124.2015.1072046 DB - PRIME DP - Unbound Medicine ER -