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Psychosocial Functioning and Health-Related Quality of Life Associated with Posttraumatic Stress Disorder in Male and Female Iraq and Afghanistan War Veterans: The VALOR Registry.
J Womens Health (Larchmt). 2015 Dec; 24(12):1038-46.JW

Abstract

OBJECTIVES

Iraq and Afghanistan war veterans suffer from high rates of posttraumatic stress disorder (PTSD). Given the growing number of women in the military, there is a critical need to understand the nature and extent of potential gender differences in PTSD-associated psychosocial functioning and health-related quality of life (HRQOL) in Operation Enduring Freedom (OEF)/Operation Iraqi Freedom (OIF) veterans, which has not been studied to date.

METHODS

We used data from a gender-balanced national patient registry of warzone-deployed OEF/OIF veterans (Project VALOR: Veterans After-Discharge Longitudinal Registry) to determine the impact of gender on PTSD-related psychosocial functioning and HRQOL in 1,530 United States Iraq and Afghanistan war veterans (50% female) with and without PTSD. Overall psychosocial functioning was assessed with the Inventory of Psychosocial Functioning (IPF) and mental and physical HRQOL with the Veterans RAND 12-item Health Survey (VR-12) Mental and Physical Component Summary scores, respectively. Stratified linear regression models estimated gender-specific associations, controlling for demographic, deployment, and postdeployment factors. Interaction models tested for significant effect moderation by gender.

RESULTS

In gender-stratified models, PTSD was strongly associated with higher IPF scores (greater functional impairment), with similar associations by gender. PTSD was also associated with lower Mental Component Summary scores (lower mental HRQOL) in both men and women, with no evidence of effect moderation by gender. PTSD was associated with lower Physical Component Summery scores in women but not men in adjusted models; however, interactions were not significant.

CONCLUSION

PTSD among warzone-deployed OEF/OIF veterans is associated with significant impairments in both overall psychosocial functioning and HRQOL, with associations that are largely similar by gender. Findings support the need for thorough and continuous assessment of functional impairment and HRQOL during treatment of PTSD for both male and female OEF/OIF veterans.

Authors+Show Affiliations

1 Division of Epidemiology, New England Research Institutes , Inc., Watertown, Massachusetts.2 Executive Division, National Center for PTSD, VA Medical Center , White River Junction, Vermont. 3 Department of Psychiatry, Geisel School of Medicine of Dartmouth , Hanover, New Hampshire.4 Behavioral Science Division, National Center for PTSD at VA Boston , Boston, Massachusetts.4 Behavioral Science Division, National Center for PTSD at VA Boston , Boston, Massachusetts. 5 Department of Psychiatry, Boston University School of Medicine , Boston, Massachusetts.4 Behavioral Science Division, National Center for PTSD at VA Boston , Boston, Massachusetts. 5 Department of Psychiatry, Boston University School of Medicine , Boston, Massachusetts.4 Behavioral Science Division, National Center for PTSD at VA Boston , Boston, Massachusetts. 5 Department of Psychiatry, Boston University School of Medicine , Boston, Massachusetts.1 Division of Epidemiology, New England Research Institutes , Inc., Watertown, Massachusetts.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

26204466

Citation

Fang, Shona C., et al. "Psychosocial Functioning and Health-Related Quality of Life Associated With Posttraumatic Stress Disorder in Male and Female Iraq and Afghanistan War Veterans: the VALOR Registry." Journal of Women's Health (2002), vol. 24, no. 12, 2015, pp. 1038-46.
Fang SC, Schnurr PP, Kulish AL, et al. Psychosocial Functioning and Health-Related Quality of Life Associated with Posttraumatic Stress Disorder in Male and Female Iraq and Afghanistan War Veterans: The VALOR Registry. J Womens Health (Larchmt). 2015;24(12):1038-46.
Fang, S. C., Schnurr, P. P., Kulish, A. L., Holowka, D. W., Marx, B. P., Keane, T. M., & Rosen, R. (2015). Psychosocial Functioning and Health-Related Quality of Life Associated with Posttraumatic Stress Disorder in Male and Female Iraq and Afghanistan War Veterans: The VALOR Registry. Journal of Women's Health (2002), 24(12), 1038-46. https://doi.org/10.1089/jwh.2014.5096
Fang SC, et al. Psychosocial Functioning and Health-Related Quality of Life Associated With Posttraumatic Stress Disorder in Male and Female Iraq and Afghanistan War Veterans: the VALOR Registry. J Womens Health (Larchmt). 2015;24(12):1038-46. PubMed PMID: 26204466.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Psychosocial Functioning and Health-Related Quality of Life Associated with Posttraumatic Stress Disorder in Male and Female Iraq and Afghanistan War Veterans: The VALOR Registry. AU - Fang,Shona C, AU - Schnurr,Paula P, AU - Kulish,Andrea L, AU - Holowka,Darren W, AU - Marx,Brian P, AU - Keane,Terence M, AU - Rosen,Raymond, Y1 - 2015/07/23/ PY - 2015/7/24/entrez PY - 2015/7/24/pubmed PY - 2016/5/7/medline SP - 1038 EP - 46 JF - Journal of women's health (2002) JO - J Womens Health (Larchmt) VL - 24 IS - 12 N2 - OBJECTIVES: Iraq and Afghanistan war veterans suffer from high rates of posttraumatic stress disorder (PTSD). Given the growing number of women in the military, there is a critical need to understand the nature and extent of potential gender differences in PTSD-associated psychosocial functioning and health-related quality of life (HRQOL) in Operation Enduring Freedom (OEF)/Operation Iraqi Freedom (OIF) veterans, which has not been studied to date. METHODS: We used data from a gender-balanced national patient registry of warzone-deployed OEF/OIF veterans (Project VALOR: Veterans After-Discharge Longitudinal Registry) to determine the impact of gender on PTSD-related psychosocial functioning and HRQOL in 1,530 United States Iraq and Afghanistan war veterans (50% female) with and without PTSD. Overall psychosocial functioning was assessed with the Inventory of Psychosocial Functioning (IPF) and mental and physical HRQOL with the Veterans RAND 12-item Health Survey (VR-12) Mental and Physical Component Summary scores, respectively. Stratified linear regression models estimated gender-specific associations, controlling for demographic, deployment, and postdeployment factors. Interaction models tested for significant effect moderation by gender. RESULTS: In gender-stratified models, PTSD was strongly associated with higher IPF scores (greater functional impairment), with similar associations by gender. PTSD was also associated with lower Mental Component Summary scores (lower mental HRQOL) in both men and women, with no evidence of effect moderation by gender. PTSD was associated with lower Physical Component Summery scores in women but not men in adjusted models; however, interactions were not significant. CONCLUSION: PTSD among warzone-deployed OEF/OIF veterans is associated with significant impairments in both overall psychosocial functioning and HRQOL, with associations that are largely similar by gender. Findings support the need for thorough and continuous assessment of functional impairment and HRQOL during treatment of PTSD for both male and female OEF/OIF veterans. SN - 1931-843X UR - https://www.unboundmedicine.com/medline/citation/26204466/Psychosocial_Functioning_and_Health_Related_Quality_of_Life_Associated_with_Posttraumatic_Stress_Disorder_in_Male_and_Female_Iraq_and_Afghanistan_War_Veterans:_The_VALOR_Registry_ DB - PRIME DP - Unbound Medicine ER -