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Antiallodynic and antihyperalgesic effects of zerumbone on a mouse model of chronic constriction injury-induced neuropathic pain.
Fitoterapia. 2015 Sep; 105:215-21.F

Abstract

Neuropathic pain is a chronic condition that is difficult to be treated. Current therapies available are either ineffective or non-specific thus requiring newer treatment approaches. In this study, we investigated the antiallodynic and antihyperalgesic effects of zerumbone, a bioactive sesquiterpene from Zingiber zerumbet in chronic constriction injury (CCI)-induced neuropathic pain animal model. Our findings showed that single and repeated dose of intra-peritoneal administration of zerumbone (5, 10, 50, 100 mg/kg) significantly attenuated the CCI-induced neuropathic pain when evaluated using the electronic von Frey anesthesiometer, cold plate, Randall-Selitto analgesiometer and the Hargreaves plantar test. Zerumbone significantly alleviated tactile and cold allodynia as well as mechanical and thermal hyperalgesia. Our findings are in comparison to the positive control drugs thatused gabapentin (20 mg/kgi.p.) and morphine (1 mg/kgi.p.). Together, these results showed that the systemic administration of zerumbone produced marked antiallodynic and antihyperalgesic effects in the CCI-induced neuropathic pain in mice and may serve as a potential lead compound for further analysis.

Authors+Show Affiliations

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.Biomedical Science Programme, School of Diagnostic and Applied Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia. Electronic address: enoch@upm.edu.my.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26205045

Citation

Zulazmi, Nurul Atiqah, et al. "Antiallodynic and Antihyperalgesic Effects of Zerumbone On a Mouse Model of Chronic Constriction Injury-induced Neuropathic Pain." Fitoterapia, vol. 105, 2015, pp. 215-21.
Zulazmi NA, Gopalsamy B, Farouk AA, et al. Antiallodynic and antihyperalgesic effects of zerumbone on a mouse model of chronic constriction injury-induced neuropathic pain. Fitoterapia. 2015;105:215-21.
Zulazmi, N. A., Gopalsamy, B., Farouk, A. A., Sulaiman, M. R., Bharatham, B. H., & Perimal, E. K. (2015). Antiallodynic and antihyperalgesic effects of zerumbone on a mouse model of chronic constriction injury-induced neuropathic pain. Fitoterapia, 105, 215-21. https://doi.org/10.1016/j.fitote.2015.07.011
Zulazmi NA, et al. Antiallodynic and Antihyperalgesic Effects of Zerumbone On a Mouse Model of Chronic Constriction Injury-induced Neuropathic Pain. Fitoterapia. 2015;105:215-21. PubMed PMID: 26205045.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiallodynic and antihyperalgesic effects of zerumbone on a mouse model of chronic constriction injury-induced neuropathic pain. AU - Zulazmi,Nurul Atiqah, AU - Gopalsamy,Banulata, AU - Farouk,Ahmad Akira Omar, AU - Sulaiman,Mohd Roslan, AU - Bharatham,B Hemabarathy, AU - Perimal,Enoch Kumar, Y1 - 2015/07/20/ PY - 2015/05/05/received PY - 2015/07/07/revised PY - 2015/07/08/accepted PY - 2015/7/25/entrez PY - 2015/7/25/pubmed PY - 2015/12/15/medline KW - CCI KW - Neuropathic pain KW - Zerumbone KW - Zingiber zerumbet SP - 215 EP - 21 JF - Fitoterapia JO - Fitoterapia VL - 105 N2 - Neuropathic pain is a chronic condition that is difficult to be treated. Current therapies available are either ineffective or non-specific thus requiring newer treatment approaches. In this study, we investigated the antiallodynic and antihyperalgesic effects of zerumbone, a bioactive sesquiterpene from Zingiber zerumbet in chronic constriction injury (CCI)-induced neuropathic pain animal model. Our findings showed that single and repeated dose of intra-peritoneal administration of zerumbone (5, 10, 50, 100 mg/kg) significantly attenuated the CCI-induced neuropathic pain when evaluated using the electronic von Frey anesthesiometer, cold plate, Randall-Selitto analgesiometer and the Hargreaves plantar test. Zerumbone significantly alleviated tactile and cold allodynia as well as mechanical and thermal hyperalgesia. Our findings are in comparison to the positive control drugs thatused gabapentin (20 mg/kgi.p.) and morphine (1 mg/kgi.p.). Together, these results showed that the systemic administration of zerumbone produced marked antiallodynic and antihyperalgesic effects in the CCI-induced neuropathic pain in mice and may serve as a potential lead compound for further analysis. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/26205045/Antiallodynic_and_antihyperalgesic_effects_of_zerumbone_on_a_mouse_model_of_chronic_constriction_injury_induced_neuropathic_pain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0367-326X(15)30048-4 DB - PRIME DP - Unbound Medicine ER -