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Protecting cognition from aging and Alzheimer's disease: a computerized cognitive training combined with reminiscence therapy.

Abstract

OBJECTIVE

The aim of this paper was to assess the efficacy of process-based cognitive training (pb-CT) combined with reminiscence therapy (RT) in patients with mild Alzheimer's disease (mAD) and mild cognitive impairment (MCI) and in healthy elderly (HE) subjects.

METHODS

This multicenter, randomized, controlled trial involved 348 participants with mAD, MCI, and HE from four European countries. Participants were randomly assigned to two arms of a crossover design: those in arm A underwent 3 months of computerized pb-CT for memory and executive functions combined with RT and 3 months of rest; those in arm B underwent the reverse. The primary outcome was the effect of the training on memory and executive functions performance. The secondary outcome was the effect of the training on functional abilities in mAD assessed with the instrumental activities of daily living.

RESULTS

We found a significant effect of the training for memory in all three groups on delayed recall of the Rey Auditory Verbal Learning Test and for executive functions in HE on the phonological fluency test. MCI and HE participants maintained these effects at follow-up. MCI and mAD participants also showed a significant effect of the training on the Mini-mental state examination scale. Participants with mAD showed more stable instrumental activities of daily living during the training versus the rest period.

CONCLUSIONS

Our results corroborate the positive effect of pb-CT and its maintenance primarily on memory in HE and MCI participants that did not seem to be potentiated by RT. Moreover, our results are very promising for the mAD participants.

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  • Publisher Full Text
  • Authors+Show Affiliations

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    Clinical and Behavioral Neurology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.

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    Clinical and Behavioral Neurology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.

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    Singularlogic, Athens, Greece.

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    Clinical and Behavioral Neurology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.

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    Clinical and Behavioral Neurology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.

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    Clinical and Behavioral Neurology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.

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    Clinical and Behavioral Neurology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy. Department of "Medicina dei Sistemi", University of Rome "Tor Vergata", Rome, Italy.

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    Clinical and Behavioral Neurology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.

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    Clinical and Behavioral Neurology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.

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    Clinical and Behavioral Neurology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.

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    Clinical and Behavioral Neurology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.

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    Clinical and Behavioral Neurology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.

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    Clinical and Behavioral Neurology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.

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    Azienda Unità Sanitaria Locale, Forlì, Italy.

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    Azienda Unità Sanitaria Locale, Forlì, Italy.

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    CEDAF, Forlì, Italy.

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    CEDAF, Forlì, Italy.

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    Hygeia Diagnostic and Therapeutic Center, Athens, Greece.

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    Hygeia Diagnostic and Therapeutic Center, Athens, Greece.

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    Hygeia Diagnostic and Therapeutic Center, Athens, Greece.

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    Psicología y Realidad Virtual, Valencia, Spain.

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    Jaume I University of Castellón, Castellón de la Plana, Spain.

    Clinical and Behavioral Neurology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy. Department of "Medicina dei Sistemi", University of Rome "Tor Vergata", Rome, Italy.

    Source

    MeSH

    Activities of Daily Living
    Aged
    Aged, 80 and over
    Alzheimer Disease
    Cognition
    Cognitive Behavioral Therapy
    Cognitive Dysfunction
    Cross-Over Studies
    Executive Function
    Female
    Humans
    Male
    Memory
    Mental Recall
    Middle Aged
    Neuropsychological Tests
    Psychotherapy

    Pub Type(s)

    Journal Article
    Multicenter Study
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26205305

    Citation

    Barban, Francesco, et al. "Protecting Cognition From Aging and Alzheimer's Disease: a Computerized Cognitive Training Combined With Reminiscence Therapy." International Journal of Geriatric Psychiatry, vol. 31, no. 4, 2016, pp. 340-8.
    Barban F, Annicchiarico R, Pantelopoulos S, et al. Protecting cognition from aging and Alzheimer's disease: a computerized cognitive training combined with reminiscence therapy. Int J Geriatr Psychiatry. 2016;31(4):340-8.
    Barban, F., Annicchiarico, R., Pantelopoulos, S., Federici, A., Perri, R., Fadda, L., ... Caltagirone, C. (2016). Protecting cognition from aging and Alzheimer's disease: a computerized cognitive training combined with reminiscence therapy. International Journal of Geriatric Psychiatry, 31(4), pp. 340-8. doi:10.1002/gps.4328.
    Barban F, et al. Protecting Cognition From Aging and Alzheimer's Disease: a Computerized Cognitive Training Combined With Reminiscence Therapy. Int J Geriatr Psychiatry. 2016;31(4):340-8. PubMed PMID: 26205305.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Protecting cognition from aging and Alzheimer's disease: a computerized cognitive training combined with reminiscence therapy. AU - Barban,Francesco, AU - Annicchiarico,Roberta, AU - Pantelopoulos,Stelios, AU - Federici,Alessia, AU - Perri,Roberta, AU - Fadda,Lucia, AU - Carlesimo,Giovanni Augusto, AU - Ricci,Claudia, AU - Giuli,Simone, AU - Scalici,Francesco, AU - Turchetta,Chiara Stella, AU - Adriano,Fulvia, AU - Lombardi,Maria Giovanna, AU - Zaccarelli,Chiara, AU - Cirillo,Giulio, AU - Passuti,Simone, AU - Mattarelli,Paolo, AU - Lymperopoulou,Olga, AU - Sakka,Paraskevi, AU - Ntanasi,Eva, AU - Moliner,Reyes, AU - Garcia-Palacios,Azucena, AU - Caltagirone,Carlo, Y1 - 2015/07/23/ PY - 2014/12/02/received PY - 2015/06/25/accepted PY - 2015/7/25/entrez PY - 2015/7/25/pubmed PY - 2016/12/16/medline KW - Alzheimer's disease KW - aging KW - cognitive training KW - computerized training KW - mild cognitive impairment KW - reminiscence therapy SP - 340 EP - 8 JF - International journal of geriatric psychiatry JO - Int J Geriatr Psychiatry VL - 31 IS - 4 N2 - OBJECTIVE: The aim of this paper was to assess the efficacy of process-based cognitive training (pb-CT) combined with reminiscence therapy (RT) in patients with mild Alzheimer's disease (mAD) and mild cognitive impairment (MCI) and in healthy elderly (HE) subjects. METHODS: This multicenter, randomized, controlled trial involved 348 participants with mAD, MCI, and HE from four European countries. Participants were randomly assigned to two arms of a crossover design: those in arm A underwent 3 months of computerized pb-CT for memory and executive functions combined with RT and 3 months of rest; those in arm B underwent the reverse. The primary outcome was the effect of the training on memory and executive functions performance. The secondary outcome was the effect of the training on functional abilities in mAD assessed with the instrumental activities of daily living. RESULTS: We found a significant effect of the training for memory in all three groups on delayed recall of the Rey Auditory Verbal Learning Test and for executive functions in HE on the phonological fluency test. MCI and HE participants maintained these effects at follow-up. MCI and mAD participants also showed a significant effect of the training on the Mini-mental state examination scale. Participants with mAD showed more stable instrumental activities of daily living during the training versus the rest period. CONCLUSIONS: Our results corroborate the positive effect of pb-CT and its maintenance primarily on memory in HE and MCI participants that did not seem to be potentiated by RT. Moreover, our results are very promising for the mAD participants. SN - 1099-1166 UR - https://www.unboundmedicine.com/medline/citation/26205305/Protecting_cognition_from_aging_and_Alzheimer's_disease:_a_computerized_cognitive_training_combined_with_reminiscence_therapy_ L2 - https://doi.org/10.1002/gps.4328 DB - PRIME DP - Unbound Medicine ER -