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Rationale, Design, and Baseline Characteristics of the EPICOR Asia Study (Long-tErm follow-uP of antithrombotic management patterns In Acute CORonary Syndrome patients in Asia).
Clin Cardiol. 2015 Sep; 38(9):511-9.CC

Abstract

BACKGROUND

In-hospital and postdischarge mortality for acute coronary syndromes (ACS) vary across Asia and remain generally poorer than globally. The relationship between real-life antithrombotic management patterns (AMPs) and ACS-related outcomes in Asia is unclear.

METHODS

EPICOR Asia (Long-tErm follow-uP of antithrombotic management patterns In acute CORonary syndrome patients in Asia) (NCT01361386) is a prospective, multinational, observational study of patients discharged after hospitalization for an ACS, with 2-year follow-up. The aim is to describe short- and long-term (up to 2 years post-index event) AMPs in patients hospitalized for ACS and to record clinical outcomes, healthcare resource use, and self-reported health status. Pre- and in-hospital management, AMPs, and associated outcomes, with particular focus on ischemic and bleeding events, will be recorded during the 2-year follow up.

RESULTS

Between June 2011 and May 2012, 13 005 patients were enrolled. From these, 12 922 patients surviving an ACS (6616 with STEMI, 2570 with NSTEMI, and 3736 with UA) were eligible for inclusion from 219 hospitals across 8 countries and regions in Asia: China (n = 8214), Hong Kong (n = 177), India (n = 2468), Malaysia (n = 100), Singapore (n = 93), South Korea (n = 705), Thailand (n = 957), and Vietnam (n = 208).

CONCLUSIONS

EPICOR Asia will provide information regarding clinical management and AMPs for ACS patients in Asia. Impact of AMPs on clinical outcomes, healthcare resource use, and self-reported health status both during hospitalization and up to 2 years after discharge will also be described.

Authors+Show Affiliations

Department of Cardiology, Peking University First Hospital, Beijing, China.Department of Medicine, Queen Mary Hospital, Hong Kong SAR, China.Department of Cardiology, Sir Ganga Ram Hospital, New Delhi, India.Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.Department of Medicine, Cho Ray Hospital, Ho Chi Minh City, Vietnam.Cardiovascular Science Research Centre, St. George's University of London, London, United Kingdom.Department of Cardiology, Shenyang Northern Hospital, Shenyang, China.Department of Cardiology, Zhongshan Hospital, Shanghai, China.Department of Cardiology, National Heart Centre Singapore, Singapore and Duke-NUS Graduate Medical School, Singapore.Department of Cardiology, Sarawak General Hospital, Kuching, Malaysia.Health Economics Program, The George Institute for Global Health, University of Sydney, Sydney, Australia.Clinical Science Division, AstraZeneca, Osaka, Japan.Observational Research Centre, Global Medical Affairs, AstraZeneca, Madrid, Spain.Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Pub Type(s)

Journal Article
Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26206158

Citation

Huo, Yong, et al. "Rationale, Design, and Baseline Characteristics of the EPICOR Asia Study (Long-tErm follow-uP of Antithrombotic Management Patterns in Acute CORonary Syndrome Patients in Asia)." Clinical Cardiology, vol. 38, no. 9, 2015, pp. 511-9.
Huo Y, Lee SW, Sawhney JP, et al. Rationale, Design, and Baseline Characteristics of the EPICOR Asia Study (Long-tErm follow-uP of antithrombotic management patterns In Acute CORonary Syndrome patients in Asia). Clin Cardiol. 2015;38(9):511-9.
Huo, Y., Lee, S. W., Sawhney, J. P., Kim, H. S., Krittayaphong, R., Nhan, V. T., Alonso-Garcia, A., Han, Y. L., Ge, J., Chin, C. T., Ong, T. K., Jan, S., Itoh, Y., Vega, A. M., & Pocock, S. (2015). Rationale, Design, and Baseline Characteristics of the EPICOR Asia Study (Long-tErm follow-uP of antithrombotic management patterns In Acute CORonary Syndrome patients in Asia). Clinical Cardiology, 38(9), 511-9. https://doi.org/10.1002/clc.22431
Huo Y, et al. Rationale, Design, and Baseline Characteristics of the EPICOR Asia Study (Long-tErm follow-uP of Antithrombotic Management Patterns in Acute CORonary Syndrome Patients in Asia). Clin Cardiol. 2015;38(9):511-9. PubMed PMID: 26206158.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rationale, Design, and Baseline Characteristics of the EPICOR Asia Study (Long-tErm follow-uP of antithrombotic management patterns In Acute CORonary Syndrome patients in Asia). AU - Huo,Yong, AU - Lee,Stephen W-L, AU - Sawhney,Jitendra P S, AU - Kim,Hyo-Soo, AU - Krittayaphong,Rungroj, AU - Nhan,Vo T, AU - Alonso-Garcia,Angeles, AU - Han,Ya Ling, AU - Ge,Junbo, AU - Chin,Chee Tang, AU - Ong,Tiong K, AU - Jan,Stephen, AU - Itoh,Yohji, AU - Vega,Ana Maria, AU - Pocock,Stuart, Y1 - 2015/07/24/ PY - 2015/03/16/received PY - 2015/05/21/revised PY - 2015/05/24/accepted PY - 2015/7/25/entrez PY - 2015/7/25/pubmed PY - 2016/7/23/medline SP - 511 EP - 9 JF - Clinical cardiology JO - Clin Cardiol VL - 38 IS - 9 N2 - BACKGROUND: In-hospital and postdischarge mortality for acute coronary syndromes (ACS) vary across Asia and remain generally poorer than globally. The relationship between real-life antithrombotic management patterns (AMPs) and ACS-related outcomes in Asia is unclear. METHODS: EPICOR Asia (Long-tErm follow-uP of antithrombotic management patterns In acute CORonary syndrome patients in Asia) (NCT01361386) is a prospective, multinational, observational study of patients discharged after hospitalization for an ACS, with 2-year follow-up. The aim is to describe short- and long-term (up to 2 years post-index event) AMPs in patients hospitalized for ACS and to record clinical outcomes, healthcare resource use, and self-reported health status. Pre- and in-hospital management, AMPs, and associated outcomes, with particular focus on ischemic and bleeding events, will be recorded during the 2-year follow up. RESULTS: Between June 2011 and May 2012, 13 005 patients were enrolled. From these, 12 922 patients surviving an ACS (6616 with STEMI, 2570 with NSTEMI, and 3736 with UA) were eligible for inclusion from 219 hospitals across 8 countries and regions in Asia: China (n = 8214), Hong Kong (n = 177), India (n = 2468), Malaysia (n = 100), Singapore (n = 93), South Korea (n = 705), Thailand (n = 957), and Vietnam (n = 208). CONCLUSIONS: EPICOR Asia will provide information regarding clinical management and AMPs for ACS patients in Asia. Impact of AMPs on clinical outcomes, healthcare resource use, and self-reported health status both during hospitalization and up to 2 years after discharge will also be described. SN - 1932-8737 UR - https://www.unboundmedicine.com/medline/citation/26206158/Rationale_Design_and_Baseline_Characteristics_of_the_EPICOR_Asia_Study__Long_tErm_follow_uP_of_antithrombotic_management_patterns_In_Acute_CORonary_Syndrome_patients_in_Asia__ L2 - https://doi.org/10.1002/clc.22431 DB - PRIME DP - Unbound Medicine ER -