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Hepatitis C virus genotype and subtype distribution in Chinese chronic hepatitis C patients: nationwide spread of HCV genotypes 3 and 6.
Virol J. 2015 Jul 25; 12:109.VJ

Abstract

BACKGROUND

Hepatitis C virus (HCV) genotype and subtype are related to disease progression and response to antiviral therapy. Current HCV genotype and subtype distribution data, especially for genotypes 3 and 6, are limited in China. Our purpose was to investigate the current HCV genotype and subtype distributions in chronic hepatitis C patients in China.

METHODS

Chronic hepatitis C patients (n = 1012) were enrolled, and demographic information and possible transmission risk factors were collected. Serum samples were subjected to reverse-transcription polymerase chain reaction, followed by direct DNA sequencing and phylogenetic analysis of the NS5B and core/E1 regions to determine HCV genotypes/subtypes. The geographical distributions of HCV genotypes/subtypes were analyzed. Demographic information and transmission risk factors were compared between different HCV genotypes/subtypes.

RESULTS

Four genotypes and seven subtypes of HCV were detected in 970 patients. Subtypes 1b, 2a, 3a, 6a, 3b, 6n, and 1a were detected at frequencies of 71.96%, 19.90%, 3.20%, 2.16%, 1.96%, 0.41%, and 0.41%, respectively. Genotypes 3 and 6 showed an increasingly wide geographic distribution over time. Patients with subtypes 1b and 2a were older than those with 3a, 3b, 6a, and 6n subtypes (p < 0.05 in all subtypes). More genotype 1 and 2 patients underwent blood transfusion than those with genotype 3 (all p < 0.05). More genotype 3 and 6 patients had a history of intravenous drug use than those with genotypes 1 and 2 (all p < 0.05).

CONCLUSIONS

Though subtypes 1b and 2a are still the most prevalent HCV subtypes in China, genotype 3 and 6 HCV infections have already spread nationwide from southern and western China.

Authors+Show Affiliations

Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, 8 East Jingshun Street, Chaoyang District, Beijing, 100015, China. orangewei27@163.com.Center of Hepatology, Beijing Ditan Hospital, Capital Medical University, 8 East Jingshun Street, Chaoyang District, Beijing, 100015, China. sduyangsong@163.com.Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, 8 East Jingshun Street, Chaoyang District, Beijing, 100015, China. fsh626@sina.com.Center of Hepatology, Beijing Ditan Hospital, Capital Medical University, 8 East Jingshun Street, Chaoyang District, Beijing, 100015, China. wangqidl04@126.com.Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, 8 East Jingshun Street, Chaoyang District, Beijing, 100015, China. liusa1031@sina.com.Center of Hepatology, Beijing Ditan Hospital, Capital Medical University, 8 East Jingshun Street, Chaoyang District, Beijing, 100015, China. huichunxing@126.com.Center of Hepatology, Beijing Ditan Hospital, Capital Medical University, 8 East Jingshun Street, Chaoyang District, Beijing, 100015, China. xiewen6218@163.com.Department of Infectious Diseases, The Fourth Hospital of Harbin Medical University, 37 Yiyuan Street, Nangang District, Harbin, 150081, China. zlyhmu@163.com.Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, 8 East Jingshun Street, Chaoyang District, Beijing, 100015, China. chengj0817@sina.cn.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

26206422

Citation

Ju, Wei, et al. "Hepatitis C Virus Genotype and Subtype Distribution in Chinese Chronic Hepatitis C Patients: Nationwide Spread of HCV Genotypes 3 and 6." Virology Journal, vol. 12, 2015, p. 109.
Ju W, Yang S, Feng S, et al. Hepatitis C virus genotype and subtype distribution in Chinese chronic hepatitis C patients: nationwide spread of HCV genotypes 3 and 6. Virol J. 2015;12:109.
Ju, W., Yang, S., Feng, S., Wang, Q., Liu, S., Xing, H., Xie, W., Zhu, L., & Cheng, J. (2015). Hepatitis C virus genotype and subtype distribution in Chinese chronic hepatitis C patients: nationwide spread of HCV genotypes 3 and 6. Virology Journal, 12, 109. https://doi.org/10.1186/s12985-015-0341-1
Ju W, et al. Hepatitis C Virus Genotype and Subtype Distribution in Chinese Chronic Hepatitis C Patients: Nationwide Spread of HCV Genotypes 3 and 6. Virol J. 2015 Jul 25;12:109. PubMed PMID: 26206422.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis C virus genotype and subtype distribution in Chinese chronic hepatitis C patients: nationwide spread of HCV genotypes 3 and 6. AU - Ju,Wei, AU - Yang,Song, AU - Feng,Shenghu, AU - Wang,Qi, AU - Liu,Shunai, AU - Xing,Huichun, AU - Xie,Wen, AU - Zhu,Liying, AU - Cheng,Jun, Y1 - 2015/07/25/ PY - 2015/06/09/received PY - 2015/07/10/accepted PY - 2015/7/25/entrez PY - 2015/7/25/pubmed PY - 2016/2/27/medline SP - 109 EP - 109 JF - Virology journal JO - Virol J VL - 12 N2 - BACKGROUND: Hepatitis C virus (HCV) genotype and subtype are related to disease progression and response to antiviral therapy. Current HCV genotype and subtype distribution data, especially for genotypes 3 and 6, are limited in China. Our purpose was to investigate the current HCV genotype and subtype distributions in chronic hepatitis C patients in China. METHODS: Chronic hepatitis C patients (n = 1012) were enrolled, and demographic information and possible transmission risk factors were collected. Serum samples were subjected to reverse-transcription polymerase chain reaction, followed by direct DNA sequencing and phylogenetic analysis of the NS5B and core/E1 regions to determine HCV genotypes/subtypes. The geographical distributions of HCV genotypes/subtypes were analyzed. Demographic information and transmission risk factors were compared between different HCV genotypes/subtypes. RESULTS: Four genotypes and seven subtypes of HCV were detected in 970 patients. Subtypes 1b, 2a, 3a, 6a, 3b, 6n, and 1a were detected at frequencies of 71.96%, 19.90%, 3.20%, 2.16%, 1.96%, 0.41%, and 0.41%, respectively. Genotypes 3 and 6 showed an increasingly wide geographic distribution over time. Patients with subtypes 1b and 2a were older than those with 3a, 3b, 6a, and 6n subtypes (p < 0.05 in all subtypes). More genotype 1 and 2 patients underwent blood transfusion than those with genotype 3 (all p < 0.05). More genotype 3 and 6 patients had a history of intravenous drug use than those with genotypes 1 and 2 (all p < 0.05). CONCLUSIONS: Though subtypes 1b and 2a are still the most prevalent HCV subtypes in China, genotype 3 and 6 HCV infections have already spread nationwide from southern and western China. SN - 1743-422X UR - https://www.unboundmedicine.com/medline/citation/26206422/Hepatitis_C_virus_genotype_and_subtype_distribution_in_Chinese_chronic_hepatitis_C_patients:_nationwide_spread_of_HCV_genotypes_3_and_6_ L2 - https://virologyj.biomedcentral.com/articles/10.1186/s12985-015-0341-1 DB - PRIME DP - Unbound Medicine ER -