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Bat-to-human: spike features determining 'host jump' of coronaviruses SARS-CoV, MERS-CoV, and beyond.
Trends Microbiol. 2015 Aug; 23(8):468-78.TM

Abstract

Both severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are zoonotic pathogens that crossed the species barriers to infect humans. The mechanism of viral interspecies transmission is an important scientific question to be addressed. These coronaviruses contain a surface-located spike (S) protein that initiates infection by mediating receptor-recognition and membrane fusion and is therefore a key factor in host specificity. In addition, the S protein needs to be cleaved by host proteases before executing fusion, making these proteases a second determinant of coronavirus interspecies infection. Here, we summarize the progress made in the past decade in understanding the cross-species transmission of SARS-CoV and MERS-CoV by focusing on the features of the S protein, its receptor-binding characteristics, and the cleavage process involved in priming.

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Authors+Show Affiliations

Lu G
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, Sichuan, China. Electronic address: luguangwen2001@126.com.
Wang Q
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Gao GF
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Office of Director-General, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China. Electronic address: gaof@im.ac.cn.

MeSH

AnimalsChiropteraCoronavirus InfectionsHost SpecificityHumansMiddle East Respiratory Syndrome CoronavirusProtein BindingSevere acute respiratory syndrome-related coronavirusSpike Glycoprotein, CoronavirusViral TropismVirus InternalizationZoonoses

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26206723

Citation

Lu, Guangwen, et al. "Bat-to-human: Spike Features Determining 'host Jump' of Coronaviruses SARS-CoV, MERS-CoV, and Beyond." Trends in Microbiology, vol. 23, no. 8, 2015, pp. 468-78.
Lu G, Wang Q, Gao GF. Bat-to-human: spike features determining 'host jump' of coronaviruses SARS-CoV, MERS-CoV, and beyond. Trends Microbiol. 2015;23(8):468-78.
Lu, G., Wang, Q., & Gao, G. F. (2015). Bat-to-human: spike features determining 'host jump' of coronaviruses SARS-CoV, MERS-CoV, and beyond. Trends in Microbiology, 23(8), 468-78. https://doi.org/10.1016/j.tim.2015.06.003
Lu G, Wang Q, Gao GF. Bat-to-human: Spike Features Determining 'host Jump' of Coronaviruses SARS-CoV, MERS-CoV, and Beyond. Trends Microbiol. 2015;23(8):468-78. PubMed PMID: 26206723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bat-to-human: spike features determining 'host jump' of coronaviruses SARS-CoV, MERS-CoV, and beyond. AU - Lu,Guangwen, AU - Wang,Qihui, AU - Gao,George F, Y1 - 2015/07/21/ PY - 2015/05/03/received PY - 2015/06/13/revised PY - 2015/06/16/accepted PY - 2015/7/25/entrez PY - 2015/7/25/pubmed PY - 2016/4/27/medline KW - MERS-CoV KW - SARS-CoV KW - coronavirus KW - interspecies transmission KW - spike (S) KW - viral and host determinants SP - 468 EP - 78 JF - Trends in microbiology JO - Trends Microbiol VL - 23 IS - 8 N2 - Both severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are zoonotic pathogens that crossed the species barriers to infect humans. The mechanism of viral interspecies transmission is an important scientific question to be addressed. These coronaviruses contain a surface-located spike (S) protein that initiates infection by mediating receptor-recognition and membrane fusion and is therefore a key factor in host specificity. In addition, the S protein needs to be cleaved by host proteases before executing fusion, making these proteases a second determinant of coronavirus interspecies infection. Here, we summarize the progress made in the past decade in understanding the cross-species transmission of SARS-CoV and MERS-CoV by focusing on the features of the S protein, its receptor-binding characteristics, and the cleavage process involved in priming. SN - 1878-4380 UR - https://www.unboundmedicine.com/medline/citation/26206723/Bat_to_human:_spike_features_determining_'host_jump'_of_coronaviruses_SARS_CoV_MERS_CoV_and_beyond_ DB - PRIME DP - Unbound Medicine ER -