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Hypothalamo-pituitary adrenal axis and sympatho-adrenal medullary system responses to psychological stress were not attenuated in women with elevated physical fitness levels.
Endocrine. 2016 Feb; 51(2):369-79.E

Abstract

It is not clear if higher levels of cardiorespiratory fitness are associated with lower hypothalamo-pituitary adrenal (HPA) axis and sympatho-adrenal medullary (SAM) system reactivity to psychological stress in women. The association between cardio-metabolic risk markers and acute physiological responses to psychological stress in women who differ in their cardiorespiratory fitness status has also not been investigated. Women with high (n = 22) and low (n = 22) levels of fitness aged 30-50 years (in the mid-follicular phase of the menstrual cycle) were subjected to a Trier Social Stress Test (TSST) at 1500 h. Plasma concentrations of cortisol, adrenaline (Adr), noradrenaline (NA), and dopamine (DA) were measured in samples collected every 7-15 min from 1400 to 1700 h. Heart rate and blood pressure were measured at the same time points. Low-fit women had elevated serum triglyceride, cholesterol/HDL ratio, fasting glucose, and HOMA-IR levels compared with high-fit women. While cortisol, Adr, NA, HR, and blood pressure all demonstrated a significant response to the TSST, the responses of these variables did not differ significantly between high- and low-fit women in response to the TSST. Dopamine reactivity was significantly higher in the low-fit women compared with high-fit women. There was also a significant negative correlation between VO2 max and DA reactivity. These findings suggest that, for low-fit women aged 30-50 years, the response of HPA axis and SAM system to a potent acute psychological stressor is not compromised compared to that in high-fit women.

Authors+Show Affiliations

Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Melbourne, VIC, Australia.Baker IDI Heart & Diabetes Institute, Melbourne, VIC, Australia. Central Clinical School, Monash University, Melbourne, VIC, Australia.Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Melbourne, VIC, Australia.Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Melbourne, VIC, Australia.Baker IDI Heart & Diabetes Institute, Melbourne, VIC, Australia.Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Melbourne, VIC, Australia. anne.turner@deakin.edu.au.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26206752

Citation

Jayasinghe, Sisitha U., et al. "Hypothalamo-pituitary Adrenal Axis and Sympatho-adrenal Medullary System Responses to Psychological Stress Were Not Attenuated in Women With Elevated Physical Fitness Levels." Endocrine, vol. 51, no. 2, 2016, pp. 369-79.
Jayasinghe SU, Lambert GW, Torres SJ, et al. Hypothalamo-pituitary adrenal axis and sympatho-adrenal medullary system responses to psychological stress were not attenuated in women with elevated physical fitness levels. Endocrine. 2016;51(2):369-79.
Jayasinghe, S. U., Lambert, G. W., Torres, S. J., Fraser, S. F., Eikelis, N., & Turner, A. I. (2016). Hypothalamo-pituitary adrenal axis and sympatho-adrenal medullary system responses to psychological stress were not attenuated in women with elevated physical fitness levels. Endocrine, 51(2), 369-79. https://doi.org/10.1007/s12020-015-0687-6
Jayasinghe SU, et al. Hypothalamo-pituitary Adrenal Axis and Sympatho-adrenal Medullary System Responses to Psychological Stress Were Not Attenuated in Women With Elevated Physical Fitness Levels. Endocrine. 2016;51(2):369-79. PubMed PMID: 26206752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypothalamo-pituitary adrenal axis and sympatho-adrenal medullary system responses to psychological stress were not attenuated in women with elevated physical fitness levels. AU - Jayasinghe,Sisitha U, AU - Lambert,Gavin W, AU - Torres,Susan J, AU - Fraser,Steve F, AU - Eikelis,Nina, AU - Turner,Anne I, Y1 - 2015/07/24/ PY - 2015/04/09/received PY - 2015/07/10/accepted PY - 2015/7/25/entrez PY - 2015/7/25/pubmed PY - 2016/11/5/medline KW - Fitness KW - Stress KW - TSST KW - Women SP - 369 EP - 79 JF - Endocrine JO - Endocrine VL - 51 IS - 2 N2 - It is not clear if higher levels of cardiorespiratory fitness are associated with lower hypothalamo-pituitary adrenal (HPA) axis and sympatho-adrenal medullary (SAM) system reactivity to psychological stress in women. The association between cardio-metabolic risk markers and acute physiological responses to psychological stress in women who differ in their cardiorespiratory fitness status has also not been investigated. Women with high (n = 22) and low (n = 22) levels of fitness aged 30-50 years (in the mid-follicular phase of the menstrual cycle) were subjected to a Trier Social Stress Test (TSST) at 1500 h. Plasma concentrations of cortisol, adrenaline (Adr), noradrenaline (NA), and dopamine (DA) were measured in samples collected every 7-15 min from 1400 to 1700 h. Heart rate and blood pressure were measured at the same time points. Low-fit women had elevated serum triglyceride, cholesterol/HDL ratio, fasting glucose, and HOMA-IR levels compared with high-fit women. While cortisol, Adr, NA, HR, and blood pressure all demonstrated a significant response to the TSST, the responses of these variables did not differ significantly between high- and low-fit women in response to the TSST. Dopamine reactivity was significantly higher in the low-fit women compared with high-fit women. There was also a significant negative correlation between VO2 max and DA reactivity. These findings suggest that, for low-fit women aged 30-50 years, the response of HPA axis and SAM system to a potent acute psychological stressor is not compromised compared to that in high-fit women. SN - 1559-0100 UR - https://www.unboundmedicine.com/medline/citation/26206752/Hypothalamo_pituitary_adrenal_axis_and_sympatho_adrenal_medullary_system_responses_to_psychological_stress_were_not_attenuated_in_women_with_elevated_physical_fitness_levels_ L2 - https://dx.doi.org/10.1007/s12020-015-0687-6 DB - PRIME DP - Unbound Medicine ER -