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Prehabilitation with Whey Protein Supplementation on Perioperative Functional Exercise Capacity in Patients Undergoing Colorectal Resection for Cancer: A Pilot Double-Blinded Randomized Placebo-Controlled Trial.
J Acad Nutr Diet 2016; 116(5):802-12JA

Abstract

BACKGROUND

A previous comprehensive prehabilitation program, providing nutrition counseling with whey protein supplementation, exercise, and psychological care, initiated 4 weeks before colorectal surgery for cancer, improved functional capacity before surgery and accelerated functional recovery. Those receiving standard of care deteriorated. The specific role of nutritional prehabilitation alone on functional recovery is unknown.

OBJECTIVE

This study was undertaken to estimate the impact of nutrition counseling with whey protein on preoperative functional walking capacity and recovery in patients undergoing colorectal resection for cancer.

DESIGN

We conducted a double-blinded randomized controlled trial at a single university-affiliated tertiary center located in Montreal, Quebec, Canada. Colon cancer patients (n=48) awaiting elective surgery for nonmetastatic disease were randomized to receive either individualized nutrition counseling with whey protein supplementation to meet protein needs or individualized nutrition counseling with a nonnutritive placebo. Counseling and supplementation began 4 weeks before surgery and continued for 4 weeks after surgery.

MAIN OUTCOME MEASURE

The primary outcome was change in functional walking capacity as measured with the 6-minute walk test. The distance was recorded at baseline, the day of surgery, and 4 weeks after surgery. A change of 20 m was considered clinically meaningful.

RESULTS

The whey group experienced a mean improvement in functional walking capacity before surgery of +20.8 m, with a standard deviation of 42.6 m, and the placebo group improved by +1.2 (65.5) m (P=0.27). Four weeks after surgery, recovery rates were similar between groups (P=0.81).

CONCLUSION

Clinically meaningful improvements in functional walking capacity were achieved before surgery with whey protein supplementation. These pilot results are encouraging and justify larger-scale trials to define the specific role of nutrition prehabilitation on functional recovery after surgery.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26208743

Citation

Gillis, Chelsia, et al. "Prehabilitation With Whey Protein Supplementation On Perioperative Functional Exercise Capacity in Patients Undergoing Colorectal Resection for Cancer: a Pilot Double-Blinded Randomized Placebo-Controlled Trial." Journal of the Academy of Nutrition and Dietetics, vol. 116, no. 5, 2016, pp. 802-12.
Gillis C, Loiselle SE, Fiore JF, et al. Prehabilitation with Whey Protein Supplementation on Perioperative Functional Exercise Capacity in Patients Undergoing Colorectal Resection for Cancer: A Pilot Double-Blinded Randomized Placebo-Controlled Trial. J Acad Nutr Diet. 2016;116(5):802-12.
Gillis, C., Loiselle, S. E., Fiore, J. F., Awasthi, R., Wykes, L., Liberman, A. S., ... Carli, F. (2016). Prehabilitation with Whey Protein Supplementation on Perioperative Functional Exercise Capacity in Patients Undergoing Colorectal Resection for Cancer: A Pilot Double-Blinded Randomized Placebo-Controlled Trial. Journal of the Academy of Nutrition and Dietetics, 116(5), pp. 802-12. doi:10.1016/j.jand.2015.06.007.
Gillis C, et al. Prehabilitation With Whey Protein Supplementation On Perioperative Functional Exercise Capacity in Patients Undergoing Colorectal Resection for Cancer: a Pilot Double-Blinded Randomized Placebo-Controlled Trial. J Acad Nutr Diet. 2016;116(5):802-12. PubMed PMID: 26208743.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prehabilitation with Whey Protein Supplementation on Perioperative Functional Exercise Capacity in Patients Undergoing Colorectal Resection for Cancer: A Pilot Double-Blinded Randomized Placebo-Controlled Trial. AU - Gillis,Chelsia, AU - Loiselle,Sarah-Eve, AU - Fiore,Julio F,Jr AU - Awasthi,Rashami, AU - Wykes,Linda, AU - Liberman,A Sender, AU - Stein,Barry, AU - Charlebois,Patrick, AU - Carli,Francesco, Y1 - 2015/07/21/ PY - 2014/08/28/received PY - 2015/06/03/accepted PY - 2015/7/26/entrez PY - 2015/7/26/pubmed PY - 2017/2/9/medline KW - Colorectal surgery KW - Functional capacity KW - Prehabilitation KW - Recovery KW - Whey protein SP - 802 EP - 12 JF - Journal of the Academy of Nutrition and Dietetics JO - J Acad Nutr Diet VL - 116 IS - 5 N2 - BACKGROUND: A previous comprehensive prehabilitation program, providing nutrition counseling with whey protein supplementation, exercise, and psychological care, initiated 4 weeks before colorectal surgery for cancer, improved functional capacity before surgery and accelerated functional recovery. Those receiving standard of care deteriorated. The specific role of nutritional prehabilitation alone on functional recovery is unknown. OBJECTIVE: This study was undertaken to estimate the impact of nutrition counseling with whey protein on preoperative functional walking capacity and recovery in patients undergoing colorectal resection for cancer. DESIGN: We conducted a double-blinded randomized controlled trial at a single university-affiliated tertiary center located in Montreal, Quebec, Canada. Colon cancer patients (n=48) awaiting elective surgery for nonmetastatic disease were randomized to receive either individualized nutrition counseling with whey protein supplementation to meet protein needs or individualized nutrition counseling with a nonnutritive placebo. Counseling and supplementation began 4 weeks before surgery and continued for 4 weeks after surgery. MAIN OUTCOME MEASURE: The primary outcome was change in functional walking capacity as measured with the 6-minute walk test. The distance was recorded at baseline, the day of surgery, and 4 weeks after surgery. A change of 20 m was considered clinically meaningful. RESULTS: The whey group experienced a mean improvement in functional walking capacity before surgery of +20.8 m, with a standard deviation of 42.6 m, and the placebo group improved by +1.2 (65.5) m (P=0.27). Four weeks after surgery, recovery rates were similar between groups (P=0.81). CONCLUSION: Clinically meaningful improvements in functional walking capacity were achieved before surgery with whey protein supplementation. These pilot results are encouraging and justify larger-scale trials to define the specific role of nutrition prehabilitation on functional recovery after surgery. SN - 2212-2672 UR - https://www.unboundmedicine.com/medline/citation/26208743/Prehabilitation_with_Whey_Protein_Supplementation_on_Perioperative_Functional_Exercise_Capacity_in_Patients_Undergoing_Colorectal_Resection_for_Cancer:_A_Pilot_Double_Blinded_Randomized_Placebo_Controlled_Trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2212-2672(15)00658-9 DB - PRIME DP - Unbound Medicine ER -