Tags

Type your tag names separated by a space and hit enter

Child Gain Approach and Loss Avoidance Behavior: Relationships With Depression Risk, Negative Mood, and Anhedonia.
J Am Acad Child Adolesc Psychiatry. 2015 Aug; 54(8):643-51.JA

Abstract

OBJECTIVE

Reduced reward responsiveness and altered response to loss of reward are observed in adults with major depressive disorder (MDD) and adolescents at increased risk for MDD based on family history. However, it is unclear whether altered behavioral responsiveness to reward/loss is a lifelong marker of MDD risk, which is evident before the normative adolescent increase in incentive responding.

METHOD

Healthy 7- to 10-year-old children of mothers with MDD (high risk: n = 27) or without MDD (low risk: n = 42) performed 2 signal detection tasks assessing response bias toward reward (approach) and away from loss (avoidance). Differences in approach/avoidance were related to MDD risk, child general depressive symptoms (maternal report), child-reported anhedonic symptoms, and child-reported negative mood symptoms via repeated-measures analysis of variance.

RESULTS

MDD risk did not significantly relate to gain approach or loss avoidance. However, within high-risk children, higher numbers of maternal depressive episodes predicted blunted loss avoidance. Blunted gain approach was related to elevated anhedonic symptoms, whereas enhanced loss avoidance was related to elevated negative mood. Elevated negative mood was further related to blunted gain approach in high-risk children but related to enhanced gain approach in low-risk children.

CONCLUSION

In children, individual differences in specific depressive symptoms and recurrence of maternal depression significantly predicted gain approach/loss avoidance, but the presence/absence of maternal MDD did not. Child depressive symptoms characterized by low positive affect (anhedonia) were related to blunted gain responsiveness, whereas elevated depressed/negative mood was related to enhanced loss responsiveness. Findings suggest that relations between gain approach and negative mood may be an important distinction between those at high versus low risk for MDD.

Authors+Show Affiliations

Neuroscience Program at Washington University in St. Louis. Electronic address: katherine.luking@gmail.com.Neuroscience Program at Washington University in St. Louis.Washington University in St. Louis.Washington University in St. Louis.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26210333

Citation

Luking, Katherine R., et al. "Child Gain Approach and Loss Avoidance Behavior: Relationships With Depression Risk, Negative Mood, and Anhedonia." Journal of the American Academy of Child and Adolescent Psychiatry, vol. 54, no. 8, 2015, pp. 643-51.
Luking KR, Pagliaccio D, Luby JL, et al. Child Gain Approach and Loss Avoidance Behavior: Relationships With Depression Risk, Negative Mood, and Anhedonia. J Am Acad Child Adolesc Psychiatry. 2015;54(8):643-51.
Luking, K. R., Pagliaccio, D., Luby, J. L., & Barch, D. M. (2015). Child Gain Approach and Loss Avoidance Behavior: Relationships With Depression Risk, Negative Mood, and Anhedonia. Journal of the American Academy of Child and Adolescent Psychiatry, 54(8), 643-51. https://doi.org/10.1016/j.jaac.2015.05.010
Luking KR, et al. Child Gain Approach and Loss Avoidance Behavior: Relationships With Depression Risk, Negative Mood, and Anhedonia. J Am Acad Child Adolesc Psychiatry. 2015;54(8):643-51. PubMed PMID: 26210333.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Child Gain Approach and Loss Avoidance Behavior: Relationships With Depression Risk, Negative Mood, and Anhedonia. AU - Luking,Katherine R, AU - Pagliaccio,David, AU - Luby,Joan L, AU - Barch,Deanna M, Y1 - 2015/06/05/ PY - 2014/11/15/received PY - 2015/05/27/revised PY - 2015/05/31/accepted PY - 2015/7/27/entrez PY - 2015/7/27/pubmed PY - 2016/4/20/medline KW - anhedonia KW - depression risk KW - punishment KW - reward SP - 643 EP - 51 JF - Journal of the American Academy of Child and Adolescent Psychiatry JO - J Am Acad Child Adolesc Psychiatry VL - 54 IS - 8 N2 - OBJECTIVE: Reduced reward responsiveness and altered response to loss of reward are observed in adults with major depressive disorder (MDD) and adolescents at increased risk for MDD based on family history. However, it is unclear whether altered behavioral responsiveness to reward/loss is a lifelong marker of MDD risk, which is evident before the normative adolescent increase in incentive responding. METHOD: Healthy 7- to 10-year-old children of mothers with MDD (high risk: n = 27) or without MDD (low risk: n = 42) performed 2 signal detection tasks assessing response bias toward reward (approach) and away from loss (avoidance). Differences in approach/avoidance were related to MDD risk, child general depressive symptoms (maternal report), child-reported anhedonic symptoms, and child-reported negative mood symptoms via repeated-measures analysis of variance. RESULTS: MDD risk did not significantly relate to gain approach or loss avoidance. However, within high-risk children, higher numbers of maternal depressive episodes predicted blunted loss avoidance. Blunted gain approach was related to elevated anhedonic symptoms, whereas enhanced loss avoidance was related to elevated negative mood. Elevated negative mood was further related to blunted gain approach in high-risk children but related to enhanced gain approach in low-risk children. CONCLUSION: In children, individual differences in specific depressive symptoms and recurrence of maternal depression significantly predicted gain approach/loss avoidance, but the presence/absence of maternal MDD did not. Child depressive symptoms characterized by low positive affect (anhedonia) were related to blunted gain responsiveness, whereas elevated depressed/negative mood was related to enhanced loss responsiveness. Findings suggest that relations between gain approach and negative mood may be an important distinction between those at high versus low risk for MDD. SN - 1527-5418 UR - https://www.unboundmedicine.com/medline/citation/26210333/Child_Gain_Approach_and_Loss_Avoidance_Behavior:_Relationships_With_Depression_Risk_Negative_Mood_and_Anhedonia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-8567(15)00349-4 DB - PRIME DP - Unbound Medicine ER -