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Middle East respiratory syndrome coronavirus (MERS-CoV): A cluster analysis with implications for global management of suspected cases.
Travel Med Infect Dis. 2015 Jul-Aug; 13(4):311-4.TM

Abstract

Since the initial description of the Middle East respiratory syndrome (MERS) in September 2012, a total of 1038 cases of MERS-CoV including 460 deaths have been reported from Saudi Arabia. From August 24, 2013 to September 3, 2013, a total of 397 patients and contacts were tested for MERS-CoV. Of those tested, there were 18 (4.5%) MERS-CoV cases reported in Al-Madinah al-Munawwarah with one large cluster. In this report, we describe the outcome, epidemiology and clinical characteristics of this cluster of which 4 cases involved healthcare workers. Fourteen cases appeared to be linked to one cluster involving healthcare workers (HCWs), family and patient contacts. Of the 18 cases, five (including 2 HCWs) were community acquired, two were household contacts, and 11 were healthcare associated (including 4 HCWs). All except 4 cases were symptomatic and the case fatality rate was 39% (7 of 18). The outbreak resulted in human to human transmission of an estimated 6 cases. Contact screening showed positive test in 1 of 56 (1.8%) household contacts, and 3 of 250 (1.2%) HCWs.

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Authors+Show Affiliations

Memish ZA
Ministry of Health, Riyadh, Saudi Arabia; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. Electronic address: zmemish@yahoo.com.
Al-Tawfiq JA
Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: jaltawfi@yahoo.com.
Alhakeem RF
Ministry of Health, Riyadh, Saudi Arabia.
Assiri A
Ministry of Health, Riyadh, Saudi Arabia.
Alharby KD
Regional Health Directorate, Ministry of Health, Madinah, Saudi Arabia.
Almahallawi MS
Regional Health Directorate, Ministry of Health, Madinah, Saudi Arabia.
Alkhallawi M
Regional Health Directorate, Ministry of Health, Madinah, Saudi Arabia.

MeSH

Cluster AnalysisContact TracingCoronavirus InfectionsCross InfectionDisease OutbreaksFemaleHumansMaleMiddle East Respiratory Syndrome CoronavirusSaudi Arabia

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26211569

Citation

Memish, Ziad A., et al. "Middle East Respiratory Syndrome Coronavirus (MERS-CoV): a Cluster Analysis With Implications for Global Management of Suspected Cases." Travel Medicine and Infectious Disease, vol. 13, no. 4, 2015, pp. 311-4.
Memish ZA, Al-Tawfiq JA, Alhakeem RF, et al. Middle East respiratory syndrome coronavirus (MERS-CoV): A cluster analysis with implications for global management of suspected cases. Travel Med Infect Dis. 2015;13(4):311-4.
Memish, Z. A., Al-Tawfiq, J. A., Alhakeem, R. F., Assiri, A., Alharby, K. D., Almahallawi, M. S., & Alkhallawi, M. (2015). Middle East respiratory syndrome coronavirus (MERS-CoV): A cluster analysis with implications for global management of suspected cases. Travel Medicine and Infectious Disease, 13(4), 311-4. https://doi.org/10.1016/j.tmaid.2015.06.012
Memish ZA, et al. Middle East Respiratory Syndrome Coronavirus (MERS-CoV): a Cluster Analysis With Implications for Global Management of Suspected Cases. Travel Med Infect Dis. 2015 Jul-Aug;13(4):311-4. PubMed PMID: 26211569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Middle East respiratory syndrome coronavirus (MERS-CoV): A cluster analysis with implications for global management of suspected cases. AU - Memish,Ziad A, AU - Al-Tawfiq,Jaffar A, AU - Alhakeem,Rafat F, AU - Assiri,Abdullah, AU - Alharby,Khalid D, AU - Almahallawi,Maher S, AU - Alkhallawi,Mohammed, Y1 - 2015/07/15/ PY - 2015/06/13/received PY - 2015/06/27/revised PY - 2015/06/29/accepted PY - 2015/7/28/entrez PY - 2015/7/28/pubmed PY - 2016/2/2/medline KW - Clusters KW - Coronavirus KW - MERS-CoV KW - Middle East KW - RT-PCR SP - 311 EP - 4 JF - Travel medicine and infectious disease JO - Travel Med Infect Dis VL - 13 IS - 4 N2 - Since the initial description of the Middle East respiratory syndrome (MERS) in September 2012, a total of 1038 cases of MERS-CoV including 460 deaths have been reported from Saudi Arabia. From August 24, 2013 to September 3, 2013, a total of 397 patients and contacts were tested for MERS-CoV. Of those tested, there were 18 (4.5%) MERS-CoV cases reported in Al-Madinah al-Munawwarah with one large cluster. In this report, we describe the outcome, epidemiology and clinical characteristics of this cluster of which 4 cases involved healthcare workers. Fourteen cases appeared to be linked to one cluster involving healthcare workers (HCWs), family and patient contacts. Of the 18 cases, five (including 2 HCWs) were community acquired, two were household contacts, and 11 were healthcare associated (including 4 HCWs). All except 4 cases were symptomatic and the case fatality rate was 39% (7 of 18). The outbreak resulted in human to human transmission of an estimated 6 cases. Contact screening showed positive test in 1 of 56 (1.8%) household contacts, and 3 of 250 (1.2%) HCWs. SN - 1873-0442 UR - https://www.unboundmedicine.com/medline/citation/26211569/Middle_East_respiratory_syndrome_coronavirus__MERS_CoV_:_A_cluster_analysis_with_implications_for_global_management_of_suspected_cases_ DB - PRIME DP - Unbound Medicine ER -