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Pr-SNTX, a short-chain three-finger toxin from Papuan pigmy mulga snake, is an antagonist of muscle-type nicotinic acetylcholine receptor (α2βδε).
Biosci Biotechnol Biochem. 2016; 80(1):158-61.BB

Abstract

Three-finger toxins (3FTxs) are one of the major components in snake venoms. In this study, we isolated a cDNA encoding a short-chain 3FTx, Pr-SNTX, from Pseudechis rossignolii. The amino acid sequence of Pr-SNTX is nearly identical to that of its ortholog in Pseudechis australis. Pr-SNTX protein inhibited muscle-type (α2βδε), but not neuronal α7 nicotinic acetylcholine receptor (nAChR) activity.

Authors+Show Affiliations

a Biomedical Research Institute , National Institute of Advanced Industrial Science and Technology (AIST) , Tsukuba , Japan.a Biomedical Research Institute , National Institute of Advanced Industrial Science and Technology (AIST) , Tsukuba , Japan.b College of Animal Science and Biotechnology , Zhejiang A & F University , Lin'An , China.c Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry , Russian Academy of Sciences , Moscow , Russian Federation.c Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry , Russian Academy of Sciences , Moscow , Russian Federation.a Biomedical Research Institute , National Institute of Advanced Industrial Science and Technology (AIST) , Tsukuba , Japan. d United Graduate School of Drug Discovery and Medical Information Sciences , Gifu University , Gifu , Japan.a Biomedical Research Institute , National Institute of Advanced Industrial Science and Technology (AIST) , Tsukuba , Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26211734

Citation

Yamauchi, Yoko, et al. "Pr-SNTX, a Short-chain Three-finger Toxin From Papuan Pigmy Mulga Snake, Is an Antagonist of Muscle-type Nicotinic Acetylcholine Receptor (α2βδε)." Bioscience, Biotechnology, and Biochemistry, vol. 80, no. 1, 2016, pp. 158-61.
Yamauchi Y, Kimoto H, Yang X, et al. Pr-SNTX, a short-chain three-finger toxin from Papuan pigmy mulga snake, is an antagonist of muscle-type nicotinic acetylcholine receptor (α2βδε). Biosci Biotechnol Biochem. 2016;80(1):158-61.
Yamauchi, Y., Kimoto, H., Yang, X., Filkin, S., Utkin, Y., Kubo, T., & Inagaki, H. (2016). Pr-SNTX, a short-chain three-finger toxin from Papuan pigmy mulga snake, is an antagonist of muscle-type nicotinic acetylcholine receptor (α2βδε). Bioscience, Biotechnology, and Biochemistry, 80(1), 158-61. https://doi.org/10.1080/09168451.2015.1065169
Yamauchi Y, et al. Pr-SNTX, a Short-chain Three-finger Toxin From Papuan Pigmy Mulga Snake, Is an Antagonist of Muscle-type Nicotinic Acetylcholine Receptor (α2βδε). Biosci Biotechnol Biochem. 2016;80(1):158-61. PubMed PMID: 26211734.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pr-SNTX, a short-chain three-finger toxin from Papuan pigmy mulga snake, is an antagonist of muscle-type nicotinic acetylcholine receptor (α2βδε). AU - Yamauchi,Yoko, AU - Kimoto,Hikari, AU - Yang,Xianyu, AU - Filkin,Sergey, AU - Utkin,Yuri, AU - Kubo,Tai, AU - Inagaki,Hidetoshi, Y1 - 2015/07/25/ PY - 2015/7/28/entrez PY - 2015/7/28/pubmed PY - 2016/9/13/medline KW - Papuan pigmy mulga snake KW - nAChR KW - three-finger toxin KW - venom gland SP - 158 EP - 61 JF - Bioscience, biotechnology, and biochemistry JO - Biosci. Biotechnol. Biochem. VL - 80 IS - 1 N2 - Three-finger toxins (3FTxs) are one of the major components in snake venoms. In this study, we isolated a cDNA encoding a short-chain 3FTx, Pr-SNTX, from Pseudechis rossignolii. The amino acid sequence of Pr-SNTX is nearly identical to that of its ortholog in Pseudechis australis. Pr-SNTX protein inhibited muscle-type (α2βδε), but not neuronal α7 nicotinic acetylcholine receptor (nAChR) activity. SN - 1347-6947 UR - https://www.unboundmedicine.com/medline/citation/26211734/Pr_SNTX_a_short_chain_three_finger_toxin_from_Papuan_pigmy_mulga_snake_is_an_antagonist_of_muscle_type_nicotinic_acetylcholine_receptor__α2βδε__ L2 - http://www.tandfonline.com/doi/full/10.1080/09168451.2015.1065169 DB - PRIME DP - Unbound Medicine ER -