Tags

Type your tag names separated by a space and hit enter

Polymerized nano-curcumin attenuates neurological symptoms in EAE model of multiple sclerosis through down regulation of inflammatory and oxidative processes and enhancing neuroprotection and myelin repair.
Neuropharmacology 2015; 99:156-67N

Abstract

Multiple Sclerosis (MS) is an inflammatory demyelinating disorder of central nervous system (CNS). Polyphenol curcumin has been used in traditional medicine as an effective drug for a variety of diseases. Different formulations of curcumin are introduced to increase its stability and effectiveness. Here we have examined the effect of polymerized form of nano-curcumin (PNC) on experimental autoimmune encephalomyelitis (EAE) as an animal model of MS. EAE was induced in female Lewis rats and PNC or curcumin was daily administrated intraperitonealy from day 12-29 post immunization. When the prophylactic effect of PNC was under investigation, rats received PNC from the first day of immunization. Treatment with PNC resulted in decreased scores of disease in therapeutic and prophylactic administration when compared with control group. Staining by luxol fast blue and H&E and immuno-staining of lumbar spinal cord cross sections, confirmed a significant decrease in the amounts of demyelination, inflammation and BBB breaking down. Gene expression studies in lumbar spinal cord showed a corrected balance of pro-inflammatory and anti-inflammatory genes expression, decreased oxidative stress, improved remyelination and increased progenitor cell markers after treatment with PNC. Our results demonstrated an efficient therapeutic effect of PNC as an anti-inflammatory and anti-oxidative stress agent, with significant effects on the EAE scores and myelin repair mechanisms.

Authors+Show Affiliations

Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address: Sadeghma@modares.ac.ir.Department of Resin and Additives, Institute for Color Science and Technology, Tehran, 16765-654, Iran.Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address: mjavan@modares.ac.ir.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26211978

Citation

Mohajeri, Maryam, et al. "Polymerized Nano-curcumin Attenuates Neurological Symptoms in EAE Model of Multiple Sclerosis Through Down Regulation of Inflammatory and Oxidative Processes and Enhancing Neuroprotection and Myelin Repair." Neuropharmacology, vol. 99, 2015, pp. 156-67.
Mohajeri M, Sadeghizadeh M, Najafi F, et al. Polymerized nano-curcumin attenuates neurological symptoms in EAE model of multiple sclerosis through down regulation of inflammatory and oxidative processes and enhancing neuroprotection and myelin repair. Neuropharmacology. 2015;99:156-67.
Mohajeri, M., Sadeghizadeh, M., Najafi, F., & Javan, M. (2015). Polymerized nano-curcumin attenuates neurological symptoms in EAE model of multiple sclerosis through down regulation of inflammatory and oxidative processes and enhancing neuroprotection and myelin repair. Neuropharmacology, 99, pp. 156-67. doi:10.1016/j.neuropharm.2015.07.013.
Mohajeri M, et al. Polymerized Nano-curcumin Attenuates Neurological Symptoms in EAE Model of Multiple Sclerosis Through Down Regulation of Inflammatory and Oxidative Processes and Enhancing Neuroprotection and Myelin Repair. Neuropharmacology. 2015;99:156-67. PubMed PMID: 26211978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polymerized nano-curcumin attenuates neurological symptoms in EAE model of multiple sclerosis through down regulation of inflammatory and oxidative processes and enhancing neuroprotection and myelin repair. AU - Mohajeri,Maryam, AU - Sadeghizadeh,Majid, AU - Najafi,Farhood, AU - Javan,Mohammad, Y1 - 2015/07/23/ PY - 2015/01/20/received PY - 2015/05/24/revised PY - 2015/07/13/accepted PY - 2015/7/28/entrez PY - 2015/7/28/pubmed PY - 2016/8/25/medline KW - Experimental autoimmune encephalomyelitis (EAE) KW - Multiple Sclerosis (MS) KW - Myelin repair KW - Oxidative stress KW - Polymerized nano-curcumin SP - 156 EP - 67 JF - Neuropharmacology JO - Neuropharmacology VL - 99 N2 - Multiple Sclerosis (MS) is an inflammatory demyelinating disorder of central nervous system (CNS). Polyphenol curcumin has been used in traditional medicine as an effective drug for a variety of diseases. Different formulations of curcumin are introduced to increase its stability and effectiveness. Here we have examined the effect of polymerized form of nano-curcumin (PNC) on experimental autoimmune encephalomyelitis (EAE) as an animal model of MS. EAE was induced in female Lewis rats and PNC or curcumin was daily administrated intraperitonealy from day 12-29 post immunization. When the prophylactic effect of PNC was under investigation, rats received PNC from the first day of immunization. Treatment with PNC resulted in decreased scores of disease in therapeutic and prophylactic administration when compared with control group. Staining by luxol fast blue and H&E and immuno-staining of lumbar spinal cord cross sections, confirmed a significant decrease in the amounts of demyelination, inflammation and BBB breaking down. Gene expression studies in lumbar spinal cord showed a corrected balance of pro-inflammatory and anti-inflammatory genes expression, decreased oxidative stress, improved remyelination and increased progenitor cell markers after treatment with PNC. Our results demonstrated an efficient therapeutic effect of PNC as an anti-inflammatory and anti-oxidative stress agent, with significant effects on the EAE scores and myelin repair mechanisms. SN - 1873-7064 UR - https://www.unboundmedicine.com/medline/citation/26211978/Polymerized_nano_curcumin_attenuates_neurological_symptoms_in_EAE_model_of_multiple_sclerosis_through_down_regulation_of_inflammatory_and_oxidative_processes_and_enhancing_neuroprotection_and_myelin_repair_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3908(15)30019-8 DB - PRIME DP - Unbound Medicine ER -