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Antiglycation activity of lipophilized epigallocatechin gallate (EGCG) derivatives.
Food Chem. 2016 Jan 01; 190:1022-1026.FC

Abstract

Lipophilized EGCG derivatives were synthesized by esterification of EGCG with aliphatic fatty acids and demonstrated to possess many advantages, such as higher lipophilicity and apparent health benefits over the parent EGCG. This study used a total of seven lipophilized EGCG derivatives with fatty acids of different chain lengths attached and examined the impact of lipophilization on EGCG's antiglycation activity in vitro. The length of fatty acid chain was found to be an important factor, which positively correlated with ABTS radical scavenging capacity but long chain bulky substitutes prevented methylglyoxal (MGO) trapping. Except docosahexaenoic acid (DHA), lipophilization generally showed no interference with EGCG's in vitro inhibitory activity of advanced glycation endproducts (AGEs) formation. Therefore, the lipophilized EGCG derivatives are promising candidates worthy of further exploration for preventing AGEs accumulation in vivo and hence treating AGEs-associated diseases.

Authors+Show Affiliations

College of Food Science and Technology, Shanghai Ocean University, Shanghai, PR China.School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong.Department of Biochemistry, Memorial University of Newfoundland, St. John's, NL A1B 3X9, Canada.Department of Biochemistry, Memorial University of Newfoundland, St. John's, NL A1B 3X9, Canada.Department of Biochemistry, Memorial University of Newfoundland, St. John's, NL A1B 3X9, Canada. Electronic address: fshahidi@mun.ca.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26213070

Citation

Wang, Mingfu, et al. "Antiglycation Activity of Lipophilized Epigallocatechin Gallate (EGCG) Derivatives." Food Chemistry, vol. 190, 2016, pp. 1022-1026.
Wang M, Zhang X, Zhong YJ, et al. Antiglycation activity of lipophilized epigallocatechin gallate (EGCG) derivatives. Food Chem. 2016;190:1022-1026.
Wang, M., Zhang, X., Zhong, Y. J., Perera, N., & Shahidi, F. (2016). Antiglycation activity of lipophilized epigallocatechin gallate (EGCG) derivatives. Food Chemistry, 190, 1022-1026. https://doi.org/10.1016/j.foodchem.2015.06.033
Wang M, et al. Antiglycation Activity of Lipophilized Epigallocatechin Gallate (EGCG) Derivatives. Food Chem. 2016 Jan 1;190:1022-1026. PubMed PMID: 26213070.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiglycation activity of lipophilized epigallocatechin gallate (EGCG) derivatives. AU - Wang,Mingfu, AU - Zhang,Xinchen, AU - Zhong,Ying Joy, AU - Perera,Nishani, AU - Shahidi,Fereidoon, Y1 - 2015/06/12/ PY - 2015/01/19/received PY - 2015/05/25/revised PY - 2015/06/11/accepted PY - 2015/7/28/entrez PY - 2015/7/28/pubmed PY - 2016/2/26/medline KW - AGEs inhibition KW - Antioxidant activity KW - Lipophilized EGCG KW - MGO trapping SP - 1022 EP - 1026 JF - Food chemistry JO - Food Chem VL - 190 N2 - Lipophilized EGCG derivatives were synthesized by esterification of EGCG with aliphatic fatty acids and demonstrated to possess many advantages, such as higher lipophilicity and apparent health benefits over the parent EGCG. This study used a total of seven lipophilized EGCG derivatives with fatty acids of different chain lengths attached and examined the impact of lipophilization on EGCG's antiglycation activity in vitro. The length of fatty acid chain was found to be an important factor, which positively correlated with ABTS radical scavenging capacity but long chain bulky substitutes prevented methylglyoxal (MGO) trapping. Except docosahexaenoic acid (DHA), lipophilization generally showed no interference with EGCG's in vitro inhibitory activity of advanced glycation endproducts (AGEs) formation. Therefore, the lipophilized EGCG derivatives are promising candidates worthy of further exploration for preventing AGEs accumulation in vivo and hence treating AGEs-associated diseases. SN - 1873-7072 UR - https://www.unboundmedicine.com/medline/citation/26213070/Antiglycation_activity_of_lipophilized_epigallocatechin_gallate__EGCG__derivatives_ DB - PRIME DP - Unbound Medicine ER -