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Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders.
Eur J Pharm Sci. 2015 Oct 12; 78:264-72.EJ

Abstract

This study investigates the effects of a variety of coating materials on the flowability and dissolution of dry-coated cohesive ibuprofen powders, with the ultimate aim to use these in oral dosage forms. A mechanofusion approach was employed to apply a 1% (w/w) dry coating onto ibuprofen powder with coating materials including magnesium stearate (MgSt), L-leucine, sodium stearyl fumarate (SSF) and silica-R972. No significant difference in particle size or shape was measured following mechanofusion with any material. Powder flow behaviours characterised by the Freeman FT4 system indicated coatings of MgSt, L-leucine and silica-R972 produced a notable surface modification and substantially improved flow compared to the unprocessed and SSF-mechanofused powders. ToF-SIMS provided a qualitative measure of coating extent, and indicated a near-complete layer on the drug particle surface after dry coating with MgSt or silica-R972. Of particular note, the dissolution rates of all mechanofused powders were enhanced even with a coating of a highly hydrophobic material such as magnesium stearate. This surprising increase in dissolution rate of the mechanofused powders was attributed to the lower cohesion and the reduced agglomeration after mechanical coating.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Qu L
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
Zhou QT
Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907-2091, USA.
Denman JA
Ian Wark Research Institute, University of South Australia, Mawson Lakes, South Australia 5095, Australia.
Stewart PJ
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
Hapgood KP
Department of Chemical Engineering, Monash University, Clayton, VIC 3800, Australia.
Morton DA
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia. Electronic address: david.morton@monash.edu.

MeSH

FumaratesIbuprofenLeucineModels, ChemicalParticle SizePowdersRheologySilicon DioxideSolubilityStearic AcidsSurface Properties

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26215464

Citation

Qu, Li, et al. "Influence of Coating Material On the Flowability and Dissolution of Dry-coated Fine Ibuprofen Powders." European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, vol. 78, 2015, pp. 264-72.
Qu L, Zhou QT, Denman JA, et al. Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders. Eur J Pharm Sci. 2015;78:264-72.
Qu, L., Zhou, Q. T., Denman, J. A., Stewart, P. J., Hapgood, K. P., & Morton, D. A. (2015). Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, 78, 264-72. https://doi.org/10.1016/j.ejps.2015.07.016
Qu L, et al. Influence of Coating Material On the Flowability and Dissolution of Dry-coated Fine Ibuprofen Powders. Eur J Pharm Sci. 2015 Oct 12;78:264-72. PubMed PMID: 26215464.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders. AU - Qu,Li, AU - Zhou,Qi Tony, AU - Denman,John A, AU - Stewart,Peter J, AU - Hapgood,Karen P, AU - Morton,David A V, Y1 - 2015/07/26/ PY - 2015/06/08/received PY - 2015/07/21/revised PY - 2015/07/23/accepted PY - 2015/7/29/entrez PY - 2015/7/29/pubmed PY - 2016/6/9/medline KW - Dissolution KW - Fine cohesive powder KW - Ibuprofen KW - Mechanical dry powder coating KW - Mechanofusion KW - Powder flow SP - 264 EP - 72 JF - European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences JO - Eur J Pharm Sci VL - 78 N2 - This study investigates the effects of a variety of coating materials on the flowability and dissolution of dry-coated cohesive ibuprofen powders, with the ultimate aim to use these in oral dosage forms. A mechanofusion approach was employed to apply a 1% (w/w) dry coating onto ibuprofen powder with coating materials including magnesium stearate (MgSt), L-leucine, sodium stearyl fumarate (SSF) and silica-R972. No significant difference in particle size or shape was measured following mechanofusion with any material. Powder flow behaviours characterised by the Freeman FT4 system indicated coatings of MgSt, L-leucine and silica-R972 produced a notable surface modification and substantially improved flow compared to the unprocessed and SSF-mechanofused powders. ToF-SIMS provided a qualitative measure of coating extent, and indicated a near-complete layer on the drug particle surface after dry coating with MgSt or silica-R972. Of particular note, the dissolution rates of all mechanofused powders were enhanced even with a coating of a highly hydrophobic material such as magnesium stearate. This surprising increase in dissolution rate of the mechanofused powders was attributed to the lower cohesion and the reduced agglomeration after mechanical coating. SN - 1879-0720 UR - https://www.unboundmedicine.com/medline/citation/26215464/Influence_of_coating_material_on_the_flowability_and_dissolution_of_dry_coated_fine_ibuprofen_powders_ DB - PRIME DP - Unbound Medicine ER -