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Rural vs. urban disparities in association with lower urinary tract symptoms and benign prostatic hyperplasia in ageing men, NHANES 2001-2008.
Int J Clin Pract 2015; 69(11):1316-25IJ

Abstract

OBJECTIVE

The objective of this study was to investigate rural/urban and socio-demographic disparities in lower urinary tract symptoms and benign prostatic hyperplasia (LUTS/BPH) in a nationally representative population of men.

METHODS

Data on men age ≥40 years (N = 4,492) in the 2001-2008 National Health and Nutrition Examination Surveys were analysed. Self-report of physician-diagnosed enlarged prostate and/or BPH medication use defined recognised LUTS/BPH. Urinary symptoms without BPH diagnosis/medications defined unrecognised LUTS/BPH. Rural-Urban Commuting Area Codes assessed urbanisation. Unadjusted and multivariable associations (odds ratios (OR)) between LUTS/BPH and covariates were calculated using logistic regression.

RESULTS

Recognised and unrecognised LUTS/BPH weighted-prevalence estimates were 16.5% and 9.6%. There were no significant associations between LUTS/BPH and rural/urban status. Significant predisposing factors for increased adjusted odds of recognised and unrecognised LUTS/BPH included age, hypertension (OR=1.4;1.4), analgesic use (OR=1.4;1.4) and PSA level >4 ng/mL (OR=2.3;1.9) when adjusted for rural/urban status, race, education, income, alcohol, health insurance, health care and proton pump inhibitor (PPI) use (all p ≤ 0.1). Restricting to urban men only (N = 3,371), healthcare use (≥4visits/year) and PPI's increased adjusted odds of recognised LUTS/BPH (OR=2.0;1.6); no health insurance and <high school education decreased odds (OR=0.5;0.6) after adjusting for variables listed above, antidepressant and calcium channel blocker use (p ≤ 0.1). Also among urban men, adjusted odds of unrecognised LUTS/BPH increased for blacks (OR=1.9), Hispanic/Other (OR=1.9) and income<$34,999 (OR=1.6). Among rural men only (N = 1,121), adjusted odds of recognised and unrecognised LUTS/BPH increased for age, hypertension (OR=1.9;1.7) and analgesic use (OR=2.0;1.5) when adjusting for race, CRP, antidepressant and dyslipidaemic use (p ≤ 0.1).

CONCLUSION

Rural/urban status was not associated with significantly increased adjusted odds of either recognised or unrecognised LUTS/BPH.

Authors+Show Affiliations

New England Research Institutes, Inc., Watertown, MA, USA.New England Research Institutes, Inc., Watertown, MA, USA.New England Research Institutes, Inc., Watertown, MA, USA.Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA.Global Statistical Sciences and Advanced Analytics, Eli Lilly and Company, Indianapolis, IN, USA.Eli Lilly and Company USA, Indianapolis, IN, USA.Division of Urology, Southern Illinois University School of Medicine, Springfield, IL, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26215544

Citation

Egan, K B., et al. "Rural Vs. Urban Disparities in Association With Lower Urinary Tract Symptoms and Benign Prostatic Hyperplasia in Ageing Men, NHANES 2001-2008." International Journal of Clinical Practice, vol. 69, no. 11, 2015, pp. 1316-25.
Egan KB, Suh M, Rosen RC, et al. Rural vs. urban disparities in association with lower urinary tract symptoms and benign prostatic hyperplasia in ageing men, NHANES 2001-2008. Int J Clin Pract. 2015;69(11):1316-25.
Egan, K. B., Suh, M., Rosen, R. C., Burnett, A. L., Ni, X., Wong, D. G., & McVary, K. T. (2015). Rural vs. urban disparities in association with lower urinary tract symptoms and benign prostatic hyperplasia in ageing men, NHANES 2001-2008. International Journal of Clinical Practice, 69(11), pp. 1316-25. doi:10.1111/ijcp.12709.
Egan KB, et al. Rural Vs. Urban Disparities in Association With Lower Urinary Tract Symptoms and Benign Prostatic Hyperplasia in Ageing Men, NHANES 2001-2008. Int J Clin Pract. 2015;69(11):1316-25. PubMed PMID: 26215544.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rural vs. urban disparities in association with lower urinary tract symptoms and benign prostatic hyperplasia in ageing men, NHANES 2001-2008. AU - Egan,K B, AU - Suh,M, AU - Rosen,R C, AU - Burnett,A L, AU - Ni,X, AU - Wong,D G, AU - McVary,K T, Y1 - 2015/07/28/ PY - 2015/06/16/received PY - 2015/07/07/accepted PY - 2015/7/29/entrez PY - 2015/7/29/pubmed PY - 2016/12/15/medline SP - 1316 EP - 25 JF - International journal of clinical practice JO - Int. J. Clin. Pract. VL - 69 IS - 11 N2 - OBJECTIVE: The objective of this study was to investigate rural/urban and socio-demographic disparities in lower urinary tract symptoms and benign prostatic hyperplasia (LUTS/BPH) in a nationally representative population of men. METHODS: Data on men age ≥40 years (N = 4,492) in the 2001-2008 National Health and Nutrition Examination Surveys were analysed. Self-report of physician-diagnosed enlarged prostate and/or BPH medication use defined recognised LUTS/BPH. Urinary symptoms without BPH diagnosis/medications defined unrecognised LUTS/BPH. Rural-Urban Commuting Area Codes assessed urbanisation. Unadjusted and multivariable associations (odds ratios (OR)) between LUTS/BPH and covariates were calculated using logistic regression. RESULTS: Recognised and unrecognised LUTS/BPH weighted-prevalence estimates were 16.5% and 9.6%. There were no significant associations between LUTS/BPH and rural/urban status. Significant predisposing factors for increased adjusted odds of recognised and unrecognised LUTS/BPH included age, hypertension (OR=1.4;1.4), analgesic use (OR=1.4;1.4) and PSA level >4 ng/mL (OR=2.3;1.9) when adjusted for rural/urban status, race, education, income, alcohol, health insurance, health care and proton pump inhibitor (PPI) use (all p ≤ 0.1). Restricting to urban men only (N = 3,371), healthcare use (≥4visits/year) and PPI's increased adjusted odds of recognised LUTS/BPH (OR=2.0;1.6); no health insurance and <high school education decreased odds (OR=0.5;0.6) after adjusting for variables listed above, antidepressant and calcium channel blocker use (p ≤ 0.1). Also among urban men, adjusted odds of unrecognised LUTS/BPH increased for blacks (OR=1.9), Hispanic/Other (OR=1.9) and income<$34,999 (OR=1.6). Among rural men only (N = 1,121), adjusted odds of recognised and unrecognised LUTS/BPH increased for age, hypertension (OR=1.9;1.7) and analgesic use (OR=2.0;1.5) when adjusting for race, CRP, antidepressant and dyslipidaemic use (p ≤ 0.1). CONCLUSION: Rural/urban status was not associated with significantly increased adjusted odds of either recognised or unrecognised LUTS/BPH. SN - 1742-1241 UR - https://www.unboundmedicine.com/medline/citation/26215544/Rural_vs__urban_disparities_in_association_with_lower_urinary_tract_symptoms_and_benign_prostatic_hyperplasia_in_ageing_men_NHANES_2001_2008_ L2 - https://doi.org/10.1111/ijcp.12709 DB - PRIME DP - Unbound Medicine ER -