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Oral lichen planus: salival biomarkers cortisol, immunoglobulin A, adiponectin.
J Oral Pathol Med. 2016 Mar; 45(3):211-7.JO

Abstract

BACKGROUND

Oral lichen planus (OLP) is a chronic mucocutaneous disease, inflammatory and autoimmune in character, in which the pathogenesis is not fully understood. Psychological stress has also been implicated in triggering or exacerbating the disease.

OBJECTIVE

The aim of this study was to evaluate the psychological profile, sleep, and salivary biological markers-cortisol, immunoglobin A (IgA), and adiponectin - in patients with oral lichen planus (OLP).

METHODS

The sample consisted of 65 patients (33 with OLP and 32 control patients). Patients completed hospital anxiety and depression scales (HADD, HADA). Questionnaires were used to assess sleepiness: the Pittsburgh sleep quality index (PSQI) and the Epworth sleepiness scale (ESS). A visual analog scale (VAS) was used for rating pain. Unstimulated whole saliva was evaluated, together with total proteins: cortisol, IgA, and adiponectin.

RESULTS

Patients with OLP obtained significantly higher HADA and PSQI scores than control subjects (P = 0.001, P = 0.012, respectively). Total salivary protein (flow at rest) analysis found that total proteins were higher in the OLP group (P = 0.001). In the OLP group, IgA was 80.3 ± 51.3 vs. the control group 48.9 ± 32.8 (P = 0.005). Mean cortisol was 0.5 ± 0.3 μg/dl in the OLP group vs. 0.4 ± 0.2 μg/dl in the control group (P = 0.010). The OLP group showed a correlation between the HADA variable and pain (r = 0.358; P = 0.041), HADD (r = 0.568; P = 0.001), and PSQI (r = 0.537; P = 0.001).

CONCLUSIONS

OLP patients presented worse psychological profiles and sleep disturbances, as well as higher values for IgA, cortisol, and total proteins than control subjects.

Authors+Show Affiliations

Oral Medicine, University Dental Clinic, University of Murcia, Murcia, Spain.Oral Medicine, University Dental Clinic, University of Murcia, Murcia, Spain.Department of Animal Medicine and Surgery, Regional Campus of International Excellence Mare Nostrum, University of Murcia, Murcia, Spain.Oral Medicine, University Dental Clinic, University of Murcia, Murcia, Spain.Department of Animal Medicine and Surgery, Regional Campus of International Excellence Mare Nostrum, University of Murcia, Murcia, Spain.Department of Animal Medicine and Surgery, Regional Campus of International Excellence Mare Nostrum, University of Murcia, Murcia, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26216173

Citation

Lopez-Jornet, Pia, et al. "Oral Lichen Planus: Salival Biomarkers Cortisol, Immunoglobulin A, Adiponectin." Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, vol. 45, no. 3, 2016, pp. 211-7.
Lopez-Jornet P, Cayuela CA, Tvarijonaviciute A, et al. Oral lichen planus: salival biomarkers cortisol, immunoglobulin A, adiponectin. J Oral Pathol Med. 2016;45(3):211-7.
Lopez-Jornet, P., Cayuela, C. A., Tvarijonaviciute, A., Parra-Perez, F., Escribano, D., & Ceron, J. (2016). Oral lichen planus: salival biomarkers cortisol, immunoglobulin A, adiponectin. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 45(3), 211-7. https://doi.org/10.1111/jop.12345
Lopez-Jornet P, et al. Oral Lichen Planus: Salival Biomarkers Cortisol, Immunoglobulin A, Adiponectin. J Oral Pathol Med. 2016;45(3):211-7. PubMed PMID: 26216173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral lichen planus: salival biomarkers cortisol, immunoglobulin A, adiponectin. AU - Lopez-Jornet,Pia, AU - Cayuela,Cristina Aznar, AU - Tvarijonaviciute,Asta, AU - Parra-Perez,Francisco, AU - Escribano,Damian, AU - Ceron,Jose, Y1 - 2015/07/27/ PY - 2015/06/08/accepted PY - 2015/7/29/entrez PY - 2015/7/29/pubmed PY - 2017/1/24/medline KW - IgA KW - adiponectin KW - anxiety KW - cortisol KW - lichen planus KW - saliva SP - 211 EP - 7 JF - Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology JO - J Oral Pathol Med VL - 45 IS - 3 N2 - BACKGROUND: Oral lichen planus (OLP) is a chronic mucocutaneous disease, inflammatory and autoimmune in character, in which the pathogenesis is not fully understood. Psychological stress has also been implicated in triggering or exacerbating the disease. OBJECTIVE: The aim of this study was to evaluate the psychological profile, sleep, and salivary biological markers-cortisol, immunoglobin A (IgA), and adiponectin - in patients with oral lichen planus (OLP). METHODS: The sample consisted of 65 patients (33 with OLP and 32 control patients). Patients completed hospital anxiety and depression scales (HADD, HADA). Questionnaires were used to assess sleepiness: the Pittsburgh sleep quality index (PSQI) and the Epworth sleepiness scale (ESS). A visual analog scale (VAS) was used for rating pain. Unstimulated whole saliva was evaluated, together with total proteins: cortisol, IgA, and adiponectin. RESULTS: Patients with OLP obtained significantly higher HADA and PSQI scores than control subjects (P = 0.001, P = 0.012, respectively). Total salivary protein (flow at rest) analysis found that total proteins were higher in the OLP group (P = 0.001). In the OLP group, IgA was 80.3 ± 51.3 vs. the control group 48.9 ± 32.8 (P = 0.005). Mean cortisol was 0.5 ± 0.3 μg/dl in the OLP group vs. 0.4 ± 0.2 μg/dl in the control group (P = 0.010). The OLP group showed a correlation between the HADA variable and pain (r = 0.358; P = 0.041), HADD (r = 0.568; P = 0.001), and PSQI (r = 0.537; P = 0.001). CONCLUSIONS: OLP patients presented worse psychological profiles and sleep disturbances, as well as higher values for IgA, cortisol, and total proteins than control subjects. SN - 1600-0714 UR - https://www.unboundmedicine.com/medline/citation/26216173/Oral_lichen_planus:_salival_biomarkers_cortisol_immunoglobulin_A_adiponectin_ L2 - https://doi.org/10.1111/jop.12345 DB - PRIME DP - Unbound Medicine ER -