Tags

Type your tag names separated by a space and hit enter

Characterization of vitamin-cisplatin-loaded chitosan nano-particles for chemoprevention and cancer fatigue.

Abstract

CONTEXT

Vitamins have been shown to reduce chemotherapy-related fatigue (CRF) by conserving energy loss both during and after cancer treatment. However, it remains unknown whether this reduction of fatigue interferes with the cancer drugs or alters the effectiveness of these agents.

OBJECTIVES

The objective was to synthesize vitamin-cisplatin-loaded chitosan nano-particles for chemoprevention and cancer fatigue.

MATERIALS AND METHODS

Multi-vitamin (C, D3, and B12)-cisplatin composite nano-formulation called NanoCisVital (NCV) to overcome CRF. The interactions between vitamins and NCV were characterized using scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy, and a particle size analyser. The chemo-preventive activity was performed by in vitro bio assays.

RESULTS

SEM analysis showed spherical shape and the size is < 225 nm. NCV inhibited the proliferating yeast cells as well as denaturation of bovine serum albumin, and it also reduced the sprouting of new blood vessels in dose-dependent manner.

CONCLUSION

Collectively, these results demonstrate that the NCV particles can be used to reduce CRF without much affecting the anti-cancer properties of cisplatin.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    a Biomedical Research Laboratory, Department of Biotechnology, K L E F University (Koneru Lakshmaiah Education Foundation) Vaddeswaram , Guntur , Andhra Pradesh , India .

    , , ,

    Source

    Journal of microencapsulation 32:6 2015 pg 578-88

    MeSH

    Angiogenesis Inhibitors
    Animals
    Anti-Inflammatory Agents
    Anticarcinogenic Agents
    Antineoplastic Agents
    Biological Assay
    Cattle
    Cell Proliferation
    Chitosan
    Cisplatin
    Fatigue
    Humans
    Metal Nanoparticles
    Microscopy, Electron, Scanning
    Nanoparticles
    Neoplasms
    Particle Size
    Serum Albumin, Bovine
    Spectroscopy, Fourier Transform Infrared
    Vitamins

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    26218628

    Citation

    Othayoth, Rajath, et al. "Characterization of Vitamin-cisplatin-loaded Chitosan Nano-particles for Chemoprevention and Cancer Fatigue." Journal of Microencapsulation, vol. 32, no. 6, 2015, pp. 578-88.
    Othayoth R, Mathi P, Bheemanapally K, et al. Characterization of vitamin-cisplatin-loaded chitosan nano-particles for chemoprevention and cancer fatigue. J Microencapsul. 2015;32(6):578-88.
    Othayoth, R., Mathi, P., Bheemanapally, K., Kakarla, L., & Botlagunta, M. (2015). Characterization of vitamin-cisplatin-loaded chitosan nano-particles for chemoprevention and cancer fatigue. Journal of Microencapsulation, 32(6), pp. 578-88. doi:10.3109/02652048.2015.1065921.
    Othayoth R, et al. Characterization of Vitamin-cisplatin-loaded Chitosan Nano-particles for Chemoprevention and Cancer Fatigue. J Microencapsul. 2015;32(6):578-88. PubMed PMID: 26218628.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Characterization of vitamin-cisplatin-loaded chitosan nano-particles for chemoprevention and cancer fatigue. AU - Othayoth,Rajath, AU - Mathi,Pardhasaradhi, AU - Bheemanapally,Khaggeswar, AU - Kakarla,Lavanya, AU - Botlagunta,Mahendran, Y1 - 2015/07/28/ PY - 2015/7/29/entrez PY - 2015/7/29/pubmed PY - 2016/6/10/medline KW - Anti-proliferative KW - FT-IR KW - SEM KW - cancer-related fatigue KW - chemoprevention KW - encapsulation efficiency KW - haemolytic activity KW - nano-formulation SP - 578 EP - 88 JF - Journal of microencapsulation JO - J Microencapsul VL - 32 IS - 6 N2 - CONTEXT: Vitamins have been shown to reduce chemotherapy-related fatigue (CRF) by conserving energy loss both during and after cancer treatment. However, it remains unknown whether this reduction of fatigue interferes with the cancer drugs or alters the effectiveness of these agents. OBJECTIVES: The objective was to synthesize vitamin-cisplatin-loaded chitosan nano-particles for chemoprevention and cancer fatigue. MATERIALS AND METHODS: Multi-vitamin (C, D3, and B12)-cisplatin composite nano-formulation called NanoCisVital (NCV) to overcome CRF. The interactions between vitamins and NCV were characterized using scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy, and a particle size analyser. The chemo-preventive activity was performed by in vitro bio assays. RESULTS: SEM analysis showed spherical shape and the size is < 225 nm. NCV inhibited the proliferating yeast cells as well as denaturation of bovine serum albumin, and it also reduced the sprouting of new blood vessels in dose-dependent manner. CONCLUSION: Collectively, these results demonstrate that the NCV particles can be used to reduce CRF without much affecting the anti-cancer properties of cisplatin. SN - 1464-5246 UR - https://www.unboundmedicine.com/medline/citation/26218628/Characterization_of_vitamin_cisplatin_loaded_chitosan_nano_particles_for_chemoprevention_and_cancer_fatigue_ L2 - http://www.tandfonline.com/doi/full/10.3109/02652048.2015.1065921 DB - PRIME DP - Unbound Medicine ER -