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Characterization of vitamin-cisplatin-loaded chitosan nano-particles for chemoprevention and cancer fatigue.
J Microencapsul 2015; 32(6):578-88JM

Abstract

CONTEXT

Vitamins have been shown to reduce chemotherapy-related fatigue (CRF) by conserving energy loss both during and after cancer treatment. However, it remains unknown whether this reduction of fatigue interferes with the cancer drugs or alters the effectiveness of these agents.

OBJECTIVES

The objective was to synthesize vitamin-cisplatin-loaded chitosan nano-particles for chemoprevention and cancer fatigue.

MATERIALS AND METHODS

Multi-vitamin (C, D3, and B12)-cisplatin composite nano-formulation called NanoCisVital (NCV) to overcome CRF. The interactions between vitamins and NCV were characterized using scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy, and a particle size analyser. The chemo-preventive activity was performed by in vitro bio assays.

RESULTS

SEM analysis showed spherical shape and the size is < 225 nm. NCV inhibited the proliferating yeast cells as well as denaturation of bovine serum albumin, and it also reduced the sprouting of new blood vessels in dose-dependent manner.

CONCLUSION

Collectively, these results demonstrate that the NCV particles can be used to reduce CRF without much affecting the anti-cancer properties of cisplatin.

Authors+Show Affiliations

a Biomedical Research Laboratory, Department of Biotechnology, K L E F University (Koneru Lakshmaiah Education Foundation) Vaddeswaram , Guntur , Andhra Pradesh , India .No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26218628

Citation

Othayoth, Rajath, et al. "Characterization of Vitamin-cisplatin-loaded Chitosan Nano-particles for Chemoprevention and Cancer Fatigue." Journal of Microencapsulation, vol. 32, no. 6, 2015, pp. 578-88.
Othayoth R, Mathi P, Bheemanapally K, et al. Characterization of vitamin-cisplatin-loaded chitosan nano-particles for chemoprevention and cancer fatigue. J Microencapsul. 2015;32(6):578-88.
Othayoth, R., Mathi, P., Bheemanapally, K., Kakarla, L., & Botlagunta, M. (2015). Characterization of vitamin-cisplatin-loaded chitosan nano-particles for chemoprevention and cancer fatigue. Journal of Microencapsulation, 32(6), pp. 578-88. doi:10.3109/02652048.2015.1065921.
Othayoth R, et al. Characterization of Vitamin-cisplatin-loaded Chitosan Nano-particles for Chemoprevention and Cancer Fatigue. J Microencapsul. 2015;32(6):578-88. PubMed PMID: 26218628.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of vitamin-cisplatin-loaded chitosan nano-particles for chemoprevention and cancer fatigue. AU - Othayoth,Rajath, AU - Mathi,Pardhasaradhi, AU - Bheemanapally,Khaggeswar, AU - Kakarla,Lavanya, AU - Botlagunta,Mahendran, Y1 - 2015/07/28/ PY - 2015/7/29/entrez PY - 2015/7/29/pubmed PY - 2016/6/10/medline KW - Anti-proliferative KW - FT-IR KW - SEM KW - cancer-related fatigue KW - chemoprevention KW - encapsulation efficiency KW - haemolytic activity KW - nano-formulation SP - 578 EP - 88 JF - Journal of microencapsulation JO - J Microencapsul VL - 32 IS - 6 N2 - CONTEXT: Vitamins have been shown to reduce chemotherapy-related fatigue (CRF) by conserving energy loss both during and after cancer treatment. However, it remains unknown whether this reduction of fatigue interferes with the cancer drugs or alters the effectiveness of these agents. OBJECTIVES: The objective was to synthesize vitamin-cisplatin-loaded chitosan nano-particles for chemoprevention and cancer fatigue. MATERIALS AND METHODS: Multi-vitamin (C, D3, and B12)-cisplatin composite nano-formulation called NanoCisVital (NCV) to overcome CRF. The interactions between vitamins and NCV were characterized using scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy, and a particle size analyser. The chemo-preventive activity was performed by in vitro bio assays. RESULTS: SEM analysis showed spherical shape and the size is < 225 nm. NCV inhibited the proliferating yeast cells as well as denaturation of bovine serum albumin, and it also reduced the sprouting of new blood vessels in dose-dependent manner. CONCLUSION: Collectively, these results demonstrate that the NCV particles can be used to reduce CRF without much affecting the anti-cancer properties of cisplatin. SN - 1464-5246 UR - https://www.unboundmedicine.com/medline/citation/26218628/Characterization_of_vitamin_cisplatin_loaded_chitosan_nano_particles_for_chemoprevention_and_cancer_fatigue_ L2 - http://www.tandfonline.com/doi/full/10.3109/02652048.2015.1065921 DB - PRIME DP - Unbound Medicine ER -