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Fibroblast growth factor signaling in skeletal development and disease.
Genes Dev. 2015 Jul 15; 29(14):1463-86.GD

Abstract

Fibroblast growth factor (FGF) signaling pathways are essential regulators of vertebrate skeletal development. FGF signaling regulates development of the limb bud and formation of the mesenchymal condensation and has key roles in regulating chondrogenesis, osteogenesis, and bone and mineral homeostasis. This review updates our review on FGFs in skeletal development published in Genes & Development in 2002, examines progress made on understanding the functions of the FGF signaling pathway during critical stages of skeletogenesis, and explores the mechanisms by which mutations in FGF signaling molecules cause skeletal malformations in humans. Links between FGF signaling pathways and other interacting pathways that are critical for skeletal development and could be exploited to treat genetic diseases and repair bone are also explored.

Authors+Show Affiliations

Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110, USA;UMR-1132, Institut National de la Santé et de la Recherche Médicale, Hopital Lariboisiere, 75475 Paris Cedex 10, France; Université Paris Diderot, Sorbonne Paris Cité, 75475 Paris Cedex 10, France.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26220993

Citation

Ornitz, David M., and Pierre J. Marie. "Fibroblast Growth Factor Signaling in Skeletal Development and Disease." Genes & Development, vol. 29, no. 14, 2015, pp. 1463-86.
Ornitz DM, Marie PJ. Fibroblast growth factor signaling in skeletal development and disease. Genes Dev. 2015;29(14):1463-86.
Ornitz, D. M., & Marie, P. J. (2015). Fibroblast growth factor signaling in skeletal development and disease. Genes & Development, 29(14), 1463-86. https://doi.org/10.1101/gad.266551.115
Ornitz DM, Marie PJ. Fibroblast Growth Factor Signaling in Skeletal Development and Disease. Genes Dev. 2015 Jul 15;29(14):1463-86. PubMed PMID: 26220993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fibroblast growth factor signaling in skeletal development and disease. AU - Ornitz,David M, AU - Marie,Pierre J, PY - 2015/7/30/entrez PY - 2015/7/30/pubmed PY - 2015/10/16/medline KW - FGF KW - FGFR KW - bone KW - cartilage KW - chondrocyte KW - osteoblast SP - 1463 EP - 86 JF - Genes & development JO - Genes Dev. VL - 29 IS - 14 N2 - Fibroblast growth factor (FGF) signaling pathways are essential regulators of vertebrate skeletal development. FGF signaling regulates development of the limb bud and formation of the mesenchymal condensation and has key roles in regulating chondrogenesis, osteogenesis, and bone and mineral homeostasis. This review updates our review on FGFs in skeletal development published in Genes & Development in 2002, examines progress made on understanding the functions of the FGF signaling pathway during critical stages of skeletogenesis, and explores the mechanisms by which mutations in FGF signaling molecules cause skeletal malformations in humans. Links between FGF signaling pathways and other interacting pathways that are critical for skeletal development and could be exploited to treat genetic diseases and repair bone are also explored. SN - 1549-5477 UR - https://www.unboundmedicine.com/medline/citation/26220993/Fibroblast_growth_factor_signaling_in_skeletal_development_and_disease_ L2 - http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=26220993 DB - PRIME DP - Unbound Medicine ER -