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First Case Genotype 4 Hepatitis E Infection After a Liver Transplant.
Exp Clin Transplant. 2017 04; 15(2):228-230.EC

Abstract

Chronic hepatitis in immunosuppressed patients because of infection with hepatitis E virus is increasingly recognized, but there is a paucity of knowledge about hepatitis E virus infection in solid-organ transplant recipients. Herein, we reported the first confirmatory case of hepatitis E virus genotype 4 infection in a 47-year-old woman who underwent a liver transplant recipient in Taiwan. The patient presented with unexplained hepatitis and severe jaundice. Hepatitis E virus RNA was present in serum and identified as the genotype 4 by reverse transcription polymerase chain reaction. Pathological findings revealed that prominent zone 3 canalicular and hepatocellular cholestasis with a few acidophilic bodies and giant cell transformation, which was typical of hepatitis E virus hepatitis. Even undergoing ribavirin treatment, she had worse cholestasis and recurrent urinary tract infections. She died from encephalopathy and sepsis 6 months after the initial presentation. So far, compared with genotype 3 hepatitis E virus hepatitis, genotype 4 hepatitis E virus infection in solid-organ transplant recipients has been reported less frequently in the literature, and that warrants further accumulation of experiences.

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Authors+Show Affiliations

Wu CH
>From the Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Ho CM
No affiliation info available
Tsai JH
No affiliation info available
Sun HY
No affiliation info available
Hu RH
No affiliation info available
Lee PH
No affiliation info available

MeSH

Antiviral AgentsBiopsyFatal OutcomeFemaleGenotypeHepatitis EHepatitis E virusHepatitis, ChronicHumansLiver Function TestsLiver TransplantationMiddle AgedPhenotypePredictive Value of TestsRNA, ViralRibavirinTreatment Outcome

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

26221721

Citation

Wu, Chien-Hui, et al. "First Case Genotype 4 Hepatitis E Infection After a Liver Transplant." Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation, vol. 15, no. 2, 2017, pp. 228-230.
Wu CH, Ho CM, Tsai JH, et al. First Case Genotype 4 Hepatitis E Infection After a Liver Transplant. Exp Clin Transplant. 2017;15(2):228-230.
Wu, C. H., Ho, C. M., Tsai, J. H., Sun, H. Y., Hu, R. H., & Lee, P. H. (2017). First Case Genotype 4 Hepatitis E Infection After a Liver Transplant. Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation, 15(2), 228-230. https://doi.org/10.6002/ect.2015.0031
Wu CH, et al. First Case Genotype 4 Hepatitis E Infection After a Liver Transplant. Exp Clin Transplant. 2017;15(2):228-230. PubMed PMID: 26221721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - First Case Genotype 4 Hepatitis E Infection After a Liver Transplant. AU - Wu,Chien-Hui, AU - Ho,Cheng-Maw, AU - Tsai,Jia-Huei, AU - Sun,Hsin-Yun, AU - Hu,Rey-Heng, AU - Lee,Po-Huang, Y1 - 2015/07/29/ PY - 2015/7/30/pubmed PY - 2017/10/11/medline PY - 2015/7/30/entrez SP - 228 EP - 230 JF - Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation JO - Exp Clin Transplant VL - 15 IS - 2 N2 - Chronic hepatitis in immunosuppressed patients because of infection with hepatitis E virus is increasingly recognized, but there is a paucity of knowledge about hepatitis E virus infection in solid-organ transplant recipients. Herein, we reported the first confirmatory case of hepatitis E virus genotype 4 infection in a 47-year-old woman who underwent a liver transplant recipient in Taiwan. The patient presented with unexplained hepatitis and severe jaundice. Hepatitis E virus RNA was present in serum and identified as the genotype 4 by reverse transcription polymerase chain reaction. Pathological findings revealed that prominent zone 3 canalicular and hepatocellular cholestasis with a few acidophilic bodies and giant cell transformation, which was typical of hepatitis E virus hepatitis. Even undergoing ribavirin treatment, she had worse cholestasis and recurrent urinary tract infections. She died from encephalopathy and sepsis 6 months after the initial presentation. So far, compared with genotype 3 hepatitis E virus hepatitis, genotype 4 hepatitis E virus infection in solid-organ transplant recipients has been reported less frequently in the literature, and that warrants further accumulation of experiences. SN - 2146-8427 UR - https://www.unboundmedicine.com/medline/citation/26221721/First_Case_Genotype_4_Hepatitis_E_Infection_After_a_Liver_Transplant_ L2 - http://www.ectrx.org/forms/ectrxcontentshow.php?year=2017&volume=15&issue=2&supplement=0&makale_no=0&spage_number=228&content_type=FULL TEXT DB - PRIME DP - Unbound Medicine ER -