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Depressive-like symptoms in a reserpine-induced model of fibromyalgia in rats.
Physiol Behav. 2015 Nov 01; 151:456-62.PB

Abstract

Since the pathogenesis of fibromyalgia is unknown, treatment options are limited, ineffective and in fact based on symptom relief. A recently proposed rat model of fibromyalgia is based on central depletion of monamines caused by reserpine administration. This model showed widespread musculoskeletal pain and depressive-like symptoms, but the methodology used to measure such symptoms has been criticized. Evidence relates the high prevalence of pain and depression in fibromyalgia to common pathogenic pathways, most probably focused on the monoaminergic system. The present study aims at a validation of the reserpine model of fibromyalgia. For this purpose, rats undergoing this model have been tested for depressive-like symptoms with a Novelty-Suppressed Feeding Test adaptation. Animals administered with reserpine and subjected to forced food deprivation performed a smaller number of incursions to the center of the open field, evidenced by a decrease in the per-minute rate of the rats' approaching, smelling or touching the food. They also took more time to eat from the central food than control rats. These NSFT findings suggest the presence of depressive-like disorders in this animal model of fibromyalgia.

Authors+Show Affiliations

Department of Human Anatomy and Embryology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain.Department of Human Anatomy and Embryology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain.Department of Human Anatomy and Embryology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain.Department of Human Anatomy and Embryology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain.Department of Human Anatomy and Embryology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain.Department of Human Anatomy and Embryology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain.Department of Human Anatomy and Embryology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain.Department of Human Anatomy and Embryology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain.Department of Human Anatomy and Embryology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain. Electronic address: valverde@uv.es.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26222614

Citation

Blasco-Serra, Arantxa, et al. "Depressive-like Symptoms in a Reserpine-induced Model of Fibromyalgia in Rats." Physiology & Behavior, vol. 151, 2015, pp. 456-62.
Blasco-Serra A, Escrihuela-Vidal F, González-Soler EM, et al. Depressive-like symptoms in a reserpine-induced model of fibromyalgia in rats. Physiol Behav. 2015;151:456-62.
Blasco-Serra, A., Escrihuela-Vidal, F., González-Soler, E. M., Martínez-Expósito, F., Blasco-Ausina, M. C., Martínez-Bellver, S., Cervera-Ferri, A., Teruel-Martí, V., & Valverde-Navarro, A. A. (2015). Depressive-like symptoms in a reserpine-induced model of fibromyalgia in rats. Physiology & Behavior, 151, 456-62. https://doi.org/10.1016/j.physbeh.2015.07.033
Blasco-Serra A, et al. Depressive-like Symptoms in a Reserpine-induced Model of Fibromyalgia in Rats. Physiol Behav. 2015 Nov 1;151:456-62. PubMed PMID: 26222614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depressive-like symptoms in a reserpine-induced model of fibromyalgia in rats. AU - Blasco-Serra,Arantxa, AU - Escrihuela-Vidal,Francesc, AU - González-Soler,Eva M, AU - Martínez-Expósito,Fernando, AU - Blasco-Ausina,M Carmen, AU - Martínez-Bellver,Sergio, AU - Cervera-Ferri,Ana, AU - Teruel-Martí,Vicent, AU - Valverde-Navarro,Alfonso A, Y1 - 2015/07/26/ PY - 2015/02/19/received PY - 2015/07/17/revised PY - 2015/07/24/accepted PY - 2015/7/30/entrez PY - 2015/7/30/pubmed PY - 2016/6/29/medline KW - Animal pain model KW - Depression KW - Fibromyalgia KW - Novelty-Suppressed Feeding Test KW - Reserpine SP - 456 EP - 62 JF - Physiology & behavior JO - Physiol. Behav. VL - 151 N2 - Since the pathogenesis of fibromyalgia is unknown, treatment options are limited, ineffective and in fact based on symptom relief. A recently proposed rat model of fibromyalgia is based on central depletion of monamines caused by reserpine administration. This model showed widespread musculoskeletal pain and depressive-like symptoms, but the methodology used to measure such symptoms has been criticized. Evidence relates the high prevalence of pain and depression in fibromyalgia to common pathogenic pathways, most probably focused on the monoaminergic system. The present study aims at a validation of the reserpine model of fibromyalgia. For this purpose, rats undergoing this model have been tested for depressive-like symptoms with a Novelty-Suppressed Feeding Test adaptation. Animals administered with reserpine and subjected to forced food deprivation performed a smaller number of incursions to the center of the open field, evidenced by a decrease in the per-minute rate of the rats' approaching, smelling or touching the food. They also took more time to eat from the central food than control rats. These NSFT findings suggest the presence of depressive-like disorders in this animal model of fibromyalgia. SN - 1873-507X UR - https://www.unboundmedicine.com/medline/citation/26222614/Depressive_like_symptoms_in_a_reserpine_induced_model_of_fibromyalgia_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9384(15)30047-0 DB - PRIME DP - Unbound Medicine ER -