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Managing MERS-CoV in the healthcare setting.
Hosp Pract (1995). 2015; 43(3):158-63.HP

Abstract

Middle East respiratory Syndrome Coronavirus (MERS-CoV) has caused at least 1118 reported cases in 24 countries with at least 423 deaths worldwide. All cases are epidemiologically linked to the Arabian Penninsula with most cases reported from the Kingdom of Saudi Arabia. MERS-CoV has three patterns of presentation: sporadic isolated cases, small clusters of intra-familial transmission and large healthcare-associated infections. The disease presentation varies from asymptomatic/mild cases to severe and fatal cases. The source of the virus has focused on bats and dromedary camels but the exact mode of disease transmission continues to be debated. Current data indicate that the virus spreads from human to human through droplet and contact routes, while performing aerosole-generating procedures predispose to airborne transmission. The best diagnostic tests rely on the identification of MERS-CoV by PCR, and lower respiratory tract samples should be favoured for the diagnosis whenever this is possible in order to avoid false negative results. Recently, the World Health Organization added serology to the list of confirmatory tests. Currently, there is no proven therapy, with supportive treatment being the mainstay of treatment.

Authors+Show Affiliations

Johns Hopkins Aramco Healthcare , Dhahran , Kingdom of Saudi Arabia.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26224424

Citation

Al-Tawfiq, Jaffar A., and Ziad A. Memish. "Managing MERS-CoV in the Healthcare Setting." Hospital Practice (1995), vol. 43, no. 3, 2015, pp. 158-63.
Al-Tawfiq JA, Memish ZA. Managing MERS-CoV in the healthcare setting. Hosp Pract (1995). 2015;43(3):158-63.
Al-Tawfiq, J. A., & Memish, Z. A. (2015). Managing MERS-CoV in the healthcare setting. Hospital Practice (1995), 43(3), 158-63. https://doi.org/10.1080/21548331.2015.1074029
Al-Tawfiq JA, Memish ZA. Managing MERS-CoV in the Healthcare Setting. Hosp Pract (1995). 2015;43(3):158-63. PubMed PMID: 26224424.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Managing MERS-CoV in the healthcare setting. AU - Al-Tawfiq,Jaffar A, AU - Memish,Ziad A, PY - 2015/7/31/entrez PY - 2015/8/1/pubmed PY - 2016/3/15/medline KW - Middle east respiratory syndrome coronavirus KW - coronavirus KW - epidemiology KW - healthcare infection SP - 158 EP - 63 JF - Hospital practice (1995) JO - Hosp Pract (1995) VL - 43 IS - 3 N2 - Middle East respiratory Syndrome Coronavirus (MERS-CoV) has caused at least 1118 reported cases in 24 countries with at least 423 deaths worldwide. All cases are epidemiologically linked to the Arabian Penninsula with most cases reported from the Kingdom of Saudi Arabia. MERS-CoV has three patterns of presentation: sporadic isolated cases, small clusters of intra-familial transmission and large healthcare-associated infections. The disease presentation varies from asymptomatic/mild cases to severe and fatal cases. The source of the virus has focused on bats and dromedary camels but the exact mode of disease transmission continues to be debated. Current data indicate that the virus spreads from human to human through droplet and contact routes, while performing aerosole-generating procedures predispose to airborne transmission. The best diagnostic tests rely on the identification of MERS-CoV by PCR, and lower respiratory tract samples should be favoured for the diagnosis whenever this is possible in order to avoid false negative results. Recently, the World Health Organization added serology to the list of confirmatory tests. Currently, there is no proven therapy, with supportive treatment being the mainstay of treatment. SN - 2154-8331 UR - https://www.unboundmedicine.com/medline/citation/26224424/Managing_MERS_CoV_in_the_healthcare_setting_ L2 - https://www.tandfonline.com/doi/full/10.1080/21548331.2015.1074029 DB - PRIME DP - Unbound Medicine ER -