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Parental Body Mass Index, Gestational Weight Gain, and Risk of Macrosomia: a Population-Based Case-Control Study in China.
Paediatr Perinat Epidemiol. 2015 Sep; 29(5):462-71.PP

Abstract

BACKGROUND

The prevalence of macrosomia has risen markedly worldwide, including in China, during the past two decades. Few epidemiological studies, however, have investigated the risk factors for macrosomia in China. This study was designed to investigate the associations between parental anthropometric characteristics, gestational weight gain (GWG), and risk of macrosomia in China.

METHODS

This population-based, case-control study in Wuhan, China, included a total of 6341 subjects (870 cases and 5471 controls). Multivariable logistic regression was conducted to calculate odds ratios (OR) and 95% confidence intervals (CI).

RESULTS

Mothers or fathers who were overweight or obese before pregnancy had an elevated risk of giving birth to a macrosomic infant compared with their normal weight counterparts. Women with GWG above the Institute of Medicine (IOM) recommendation had an adjusted OR of 6.09 [95% CI 5.04, 7.35] for delivering a macrosomic infant compared with women who had GWG within the IOM recommendation. When stratified by maternal pre-pregnancy body mass index (BMI), women who were underweight or normal weight before pregnancy were observed to have a higher risk of macrosomia birth associated with greater GWG.

CONCLUSIONS

Parental pre-pregnancy overweight/obesity and excessive GWG during pregnancy were highly associated with macrosomia. The association with GWG was most pronounced in mothers who had a normal or underweight pre-pregnancy BMI. Weight control efforts before pregnancy for mothers and fathers as well as control of maternal gain during pregnancy may reduce the risk of macrosomia.

Authors+Show Affiliations

Healthcare Department, Wuhan Women and Children Medical and Healthcare Center, Wuhan, Hubei, China.Healthcare Department, Wuhan Women and Children Medical and Healthcare Center, Wuhan, Hubei, China.Healthcare Department, Wuhan Women and Children Medical and Healthcare Center, Wuhan, Hubei, China.Healthcare Department, Wuhan Women and Children Medical and Healthcare Center, Wuhan, Hubei, China.Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT.Healthcare Department, Wuhan Women and Children Medical and Healthcare Center, Wuhan, Hubei, China.Healthcare Department, Wuhan Women and Children Medical and Healthcare Center, Wuhan, Hubei, China.Healthcare Department, Wuhan Women and Children Medical and Healthcare Center, Wuhan, Hubei, China.Healthcare Department, Wuhan Women and Children Medical and Healthcare Center, Wuhan, Hubei, China.Healthcare Department, Wuhan Women and Children Medical and Healthcare Center, Wuhan, Hubei, China.Department of Epidemiology, College for Public Health and Social Justice, Saint Louis University, St. Louis, MO.Department of Epidemiology, College for Public Health and Social Justice, Saint Louis University, St. Louis, MO.Department of Epidemiology, College for Public Health and Social Justice, Saint Louis University, St. Louis, MO.Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT.Healthcare Department, Wuhan Women and Children Medical and Healthcare Center, Wuhan, Hubei, China.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

26228295

Citation

Yang, Shaoping, et al. "Parental Body Mass Index, Gestational Weight Gain, and Risk of Macrosomia: a Population-Based Case-Control Study in China." Paediatric and Perinatal Epidemiology, vol. 29, no. 5, 2015, pp. 462-71.
Yang S, Zhou A, Xiong C, et al. Parental Body Mass Index, Gestational Weight Gain, and Risk of Macrosomia: a Population-Based Case-Control Study in China. Paediatr Perinat Epidemiol. 2015;29(5):462-71.
Yang, S., Zhou, A., Xiong, C., Yang, R., Bassig, B. A., Hu, R., Zhang, Y., Yao, C., Zhang, Y., Qiu, L., Qian, Z., Trevathan, E., Flick, L., Xu, S., Wang, Y., Xia, W., Zheng, T., & Zhang, B. (2015). Parental Body Mass Index, Gestational Weight Gain, and Risk of Macrosomia: a Population-Based Case-Control Study in China. Paediatric and Perinatal Epidemiology, 29(5), 462-71. https://doi.org/10.1111/ppe.12213
Yang S, et al. Parental Body Mass Index, Gestational Weight Gain, and Risk of Macrosomia: a Population-Based Case-Control Study in China. Paediatr Perinat Epidemiol. 2015;29(5):462-71. PubMed PMID: 26228295.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parental Body Mass Index, Gestational Weight Gain, and Risk of Macrosomia: a Population-Based Case-Control Study in China. AU - Yang,Shaoping, AU - Zhou,Aifen, AU - Xiong,Chao, AU - Yang,Rong, AU - Bassig,Bryan A, AU - Hu,Ronghua, AU - Zhang,Yiming, AU - Yao,Cong, AU - Zhang,Yaqi, AU - Qiu,Lin, AU - Qian,Zhengmin, AU - Trevathan,Edwin, AU - Flick,Louise, AU - Xu,Shunqing, AU - Wang,Youjie, AU - Xia,Wei, AU - Zheng,Tongzhang, AU - Zhang,Bin, Y1 - 2015/07/30/ PY - 2015/8/1/entrez PY - 2015/8/1/pubmed PY - 2016/6/9/medline KW - China KW - body mass index KW - gestational weight gain KW - macrosomia SP - 462 EP - 71 JF - Paediatric and perinatal epidemiology JO - Paediatr Perinat Epidemiol VL - 29 IS - 5 N2 - BACKGROUND: The prevalence of macrosomia has risen markedly worldwide, including in China, during the past two decades. Few epidemiological studies, however, have investigated the risk factors for macrosomia in China. This study was designed to investigate the associations between parental anthropometric characteristics, gestational weight gain (GWG), and risk of macrosomia in China. METHODS: This population-based, case-control study in Wuhan, China, included a total of 6341 subjects (870 cases and 5471 controls). Multivariable logistic regression was conducted to calculate odds ratios (OR) and 95% confidence intervals (CI). RESULTS: Mothers or fathers who were overweight or obese before pregnancy had an elevated risk of giving birth to a macrosomic infant compared with their normal weight counterparts. Women with GWG above the Institute of Medicine (IOM) recommendation had an adjusted OR of 6.09 [95% CI 5.04, 7.35] for delivering a macrosomic infant compared with women who had GWG within the IOM recommendation. When stratified by maternal pre-pregnancy body mass index (BMI), women who were underweight or normal weight before pregnancy were observed to have a higher risk of macrosomia birth associated with greater GWG. CONCLUSIONS: Parental pre-pregnancy overweight/obesity and excessive GWG during pregnancy were highly associated with macrosomia. The association with GWG was most pronounced in mothers who had a normal or underweight pre-pregnancy BMI. Weight control efforts before pregnancy for mothers and fathers as well as control of maternal gain during pregnancy may reduce the risk of macrosomia. SN - 1365-3016 UR - https://www.unboundmedicine.com/medline/citation/26228295/Parental_Body_Mass_Index_Gestational_Weight_Gain_and_Risk_of_Macrosomia:_a_Population_Based_Case_Control_Study_in_China_ L2 - https://doi.org/10.1111/ppe.12213 DB - PRIME DP - Unbound Medicine ER -