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[Individual response to treatment: from Withering to contemporary medicine].
Recenti Prog Med 2015; 106(7):308-15RP

Abstract

This is an essay dealing with the 1785 cohort study by William Withering (the "account"), in which he reported the results of the treatment with foxglove (Digitalis purpurea) in 163 patients suffering from various forms of hydropsy (water retention). Withering reported the results of all patients, and classified them into responders and non-responders. He identified the responders as suffering from heart failure. In the 18th century, medical treatments were judged as successful if they complied with the criteria a priori of the theory of the four humors, and not on the patient's response to the treatment. Withering was the first not only to compare the patient's conditions before and after treatment, but also to identify the individual clinical characteristics of the patients who responded. In modern medicine, drugs are released on the market and approved for use after what is known as "population-derived clinical research", principally randomized controlled trials, and guidelines. More than 200 years ago, Withering anticipated the current and growing trend towards individual responses to treatment, and personalized medicine.

Authors

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Pub Type(s)

English Abstract
Historical Article
Journal Article

Language

ita

PubMed ID

26228721

Citation

Pagliaro, Luigi, et al. "[Individual Response to Treatment: From Withering to Contemporary Medicine]." Recenti Progressi in Medicina, vol. 106, no. 7, 2015, pp. 308-15.
Pagliaro L, Colli A, Bobbio M. [Individual response to treatment: from Withering to contemporary medicine]. Recenti Prog Med. 2015;106(7):308-15.
Pagliaro, L., Colli, A., & Bobbio, M. (2015). [Individual response to treatment: from Withering to contemporary medicine]. Recenti Progressi in Medicina, 106(7), pp. 308-15. doi:10.1701/1940.21084.
Pagliaro L, Colli A, Bobbio M. [Individual Response to Treatment: From Withering to Contemporary Medicine]. Recenti Prog Med. 2015;106(7):308-15. PubMed PMID: 26228721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Individual response to treatment: from Withering to contemporary medicine]. AU - Pagliaro,Luigi, AU - Colli,Agostino, AU - Bobbio,Marco, PY - 2015/8/1/entrez PY - 2015/8/1/pubmed PY - 2015/10/17/medline SP - 308 EP - 15 JF - Recenti progressi in medicina JO - Recenti Prog Med VL - 106 IS - 7 N2 - This is an essay dealing with the 1785 cohort study by William Withering (the "account"), in which he reported the results of the treatment with foxglove (Digitalis purpurea) in 163 patients suffering from various forms of hydropsy (water retention). Withering reported the results of all patients, and classified them into responders and non-responders. He identified the responders as suffering from heart failure. In the 18th century, medical treatments were judged as successful if they complied with the criteria a priori of the theory of the four humors, and not on the patient's response to the treatment. Withering was the first not only to compare the patient's conditions before and after treatment, but also to identify the individual clinical characteristics of the patients who responded. In modern medicine, drugs are released on the market and approved for use after what is known as "population-derived clinical research", principally randomized controlled trials, and guidelines. More than 200 years ago, Withering anticipated the current and growing trend towards individual responses to treatment, and personalized medicine. SN - 0034-1193 UR - https://www.unboundmedicine.com/medline/citation/26228721/[Individual_response_to_treatment:_from_Withering_to_contemporary_medicine] L2 - https://dx.doi.org/10.1701/1940.21084 DB - PRIME DP - Unbound Medicine ER -