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Current status of corneal xenotransplantation.
Int J Surg. 2015 Nov; 23(Pt B):255-260.IJ

Abstract

Corneal allo-transplantation is a well-established technique to treat corneal blindness. However, the limited availability of human donors demands the exploration of alternative treatments such as corneal xenotransplantation (e.g., pigs as donors) and bioengineered corneas. Since the first attempt of corneal xenotransplantation using a donor pig cornea in 1844, great advances have been made in the development of genetically-engineered pigs, effective immunosuppressive protocols and the establishment of guidelines for the conduction of clinical trials. We highlight immunological and physio-anatomical barriers of corneal xenotransplantation, recent progress of corneal xenotransplantation in non-human-primates studies, and regulatory guidelines to conduct clinical trials for corneal xenotransplantation.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Kim MK
Department of Ophthalmology, Seoul National University College of Medicine, Seoul, South Korea; Laboratory of Ocular Regenerative Medicine and Immunology, Seoul Artificial Eye Center, Seoul National University Hospital Biomedical Research Institute, Seoul, South Korea; Xenotransplantation Research Center, Seoul National University College of Medicine and Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea. Electronic address: kmk9@snu.ac.kr.
Hara H
Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA.

MeSH

AnimalsAnimals, Genetically ModifiedCorneaCorneal TransplantationHumansImmunosuppression TherapyPrimatesSwineTransplantation, HeterologousTransplants

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26231995

Citation

Kim, Mee Kum, and Hidetaka Hara. "Current Status of Corneal Xenotransplantation." International Journal of Surgery (London, England), vol. 23, no. Pt B, 2015, pp. 255-260.
Kim MK, Hara H. Current status of corneal xenotransplantation. Int J Surg. 2015;23(Pt B):255-260.
Kim, M. K., & Hara, H. (2015). Current status of corneal xenotransplantation. International Journal of Surgery (London, England), 23(Pt B), 255-260. https://doi.org/10.1016/j.ijsu.2015.07.685
Kim MK, Hara H. Current Status of Corneal Xenotransplantation. Int J Surg. 2015;23(Pt B):255-260. PubMed PMID: 26231995.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current status of corneal xenotransplantation. AU - Kim,Mee Kum, AU - Hara,Hidetaka, Y1 - 2015/07/29/ PY - 2015/06/24/received PY - 2015/07/15/revised PY - 2015/07/17/accepted PY - 2015/8/2/entrez PY - 2015/8/2/pubmed PY - 2016/7/30/medline KW - Clinical trial KW - Cornea KW - Guidelines KW - Nonhuman primate KW - Pig KW - Xenotransplantation SP - 255 EP - 260 JF - International journal of surgery (London, England) JO - Int J Surg VL - 23 IS - Pt B N2 - Corneal allo-transplantation is a well-established technique to treat corneal blindness. However, the limited availability of human donors demands the exploration of alternative treatments such as corneal xenotransplantation (e.g., pigs as donors) and bioengineered corneas. Since the first attempt of corneal xenotransplantation using a donor pig cornea in 1844, great advances have been made in the development of genetically-engineered pigs, effective immunosuppressive protocols and the establishment of guidelines for the conduction of clinical trials. We highlight immunological and physio-anatomical barriers of corneal xenotransplantation, recent progress of corneal xenotransplantation in non-human-primates studies, and regulatory guidelines to conduct clinical trials for corneal xenotransplantation. SN - 1743-9159 UR - https://www.unboundmedicine.com/medline/citation/26231995/Current_status_of_corneal_xenotransplantation_ DB - PRIME DP - Unbound Medicine ER -