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Effects of amount and type of dietary fats on postprandial lipemia and thrombogenic markers in individuals with metabolic syndrome.
Atherosclerosis. 2015 Sep; 242(1):281-7.A

Abstract

OBJECTIVE

Postprandial lipemia has been reported to affect endothelial function by thrombogenic and inflammatory pathways. We set out to investigate the impact of a) specific amount (50 g vs 20 g fat), and b) type of fatty acids (saturated, monounsaturated or n-6 polyunsaturated fatty acids; SFA, MUFA, PUFA) on postprandial lipemia, thrombogenic and inflammatory factors in metabolic syndrome subjects.

DESIGN

30 subjects (15 men, 15 women) participated in a double-blind, randomized crossover design study with both the subjects and investigators blinded to treatments. Blood samples were collected at fasting and 30 min, hourly interval for a total of 6 h.

RESULTS

As expected, lower triacylglycerol response was observed for low fat/high carbohydrate meal; whereas no difference was detected between the types of fatty acids. The incremental area under the curve (iAUC) for low fat/high carbohydrate meal was 70%, 81% and 61% lower than the SFA, MUFA and PUFA meals, respectively. The iAUC 0-6 h for triacylglycerol was 42% lower in women compared with the men (P = 0.024), with the similar trend observed for non-esterified fatty acids. There were significant meal × time interaction (P = 0.000) for plasma plasminogen activator inhibitor-1 and thromboxane B2 (P = 0.022) from baseline. No differences were observed between meals for plasma D-dimer, interleukin-6, interleukin-1β, tumor necrosis factor-α and high sensitivity C-reactive protein.

CONCLUSION

These data indicate that in metabolic syndrome subjects, only the amount of dietary fatty acids affects postprandial lipemia but both amount and type of dietary fats alter thrombogenic factors.

TRIAL REGISTRATION

The study was registered at Clinicaltrials.gov (NCT01571947).

Authors+Show Affiliations

Product Development and Advisory Services, Malaysian Palm Oil Board, No.6, Persiaran Institusi, Bandar Baru Bangi, 43000 Kajang, Selangor, Malaysia. Electronic address: kt.teng@gmail.com.Product Development and Advisory Services, Malaysian Palm Oil Board, No.6, Persiaran Institusi, Bandar Baru Bangi, 43000 Kajang, Selangor, Malaysia; Department of Molecular Medicine, University of Malaya Centre for Proteomics Research (UMCPR), Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: cyruschang26@gmail.com.Department of Molecular Medicine, University of Malaya Centre for Proteomics Research (UMCPR), Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: kanthi@ummc.edu.my.Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: atbtan@gmail.com.Product Development and Advisory Services, Malaysian Palm Oil Board, No.6, Persiaran Institusi, Bandar Baru Bangi, 43000 Kajang, Selangor, Malaysia. Electronic address: sarnesar@mpob.gov.my.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26232169

Citation

Teng, Kim-Tiu, et al. "Effects of Amount and Type of Dietary Fats On Postprandial Lipemia and Thrombogenic Markers in Individuals With Metabolic Syndrome." Atherosclerosis, vol. 242, no. 1, 2015, pp. 281-7.
Teng KT, Chang CY, Kanthimathi MS, et al. Effects of amount and type of dietary fats on postprandial lipemia and thrombogenic markers in individuals with metabolic syndrome. Atherosclerosis. 2015;242(1):281-7.
Teng, K. T., Chang, C. Y., Kanthimathi, M. S., Tan, A. T., & Nesaretnam, K. (2015). Effects of amount and type of dietary fats on postprandial lipemia and thrombogenic markers in individuals with metabolic syndrome. Atherosclerosis, 242(1), 281-7. https://doi.org/10.1016/j.atherosclerosis.2015.07.003
Teng KT, et al. Effects of Amount and Type of Dietary Fats On Postprandial Lipemia and Thrombogenic Markers in Individuals With Metabolic Syndrome. Atherosclerosis. 2015;242(1):281-7. PubMed PMID: 26232169.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of amount and type of dietary fats on postprandial lipemia and thrombogenic markers in individuals with metabolic syndrome. AU - Teng,Kim-Tiu, AU - Chang,Chee-Yan, AU - Kanthimathi,M S, AU - Tan,Alexander Tong Boon, AU - Nesaretnam,Kalanithi, Y1 - 2015/07/07/ PY - 2015/03/04/received PY - 2015/06/23/revised PY - 2015/07/02/accepted PY - 2015/8/2/entrez PY - 2015/8/2/pubmed PY - 2016/5/24/medline KW - Cytokines KW - Dietary fats KW - Metabolic syndrome KW - Triacylglycerol SP - 281 EP - 7 JF - Atherosclerosis JO - Atherosclerosis VL - 242 IS - 1 N2 - OBJECTIVE: Postprandial lipemia has been reported to affect endothelial function by thrombogenic and inflammatory pathways. We set out to investigate the impact of a) specific amount (50 g vs 20 g fat), and b) type of fatty acids (saturated, monounsaturated or n-6 polyunsaturated fatty acids; SFA, MUFA, PUFA) on postprandial lipemia, thrombogenic and inflammatory factors in metabolic syndrome subjects. DESIGN: 30 subjects (15 men, 15 women) participated in a double-blind, randomized crossover design study with both the subjects and investigators blinded to treatments. Blood samples were collected at fasting and 30 min, hourly interval for a total of 6 h. RESULTS: As expected, lower triacylglycerol response was observed for low fat/high carbohydrate meal; whereas no difference was detected between the types of fatty acids. The incremental area under the curve (iAUC) for low fat/high carbohydrate meal was 70%, 81% and 61% lower than the SFA, MUFA and PUFA meals, respectively. The iAUC 0-6 h for triacylglycerol was 42% lower in women compared with the men (P = 0.024), with the similar trend observed for non-esterified fatty acids. There were significant meal × time interaction (P = 0.000) for plasma plasminogen activator inhibitor-1 and thromboxane B2 (P = 0.022) from baseline. No differences were observed between meals for plasma D-dimer, interleukin-6, interleukin-1β, tumor necrosis factor-α and high sensitivity C-reactive protein. CONCLUSION: These data indicate that in metabolic syndrome subjects, only the amount of dietary fatty acids affects postprandial lipemia but both amount and type of dietary fats alter thrombogenic factors. TRIAL REGISTRATION: The study was registered at Clinicaltrials.gov (NCT01571947). SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/26232169/Effects_of_amount_and_type_of_dietary_fats_on_postprandial_lipemia_and_thrombogenic_markers_in_individuals_with_metabolic_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(15)30023-X DB - PRIME DP - Unbound Medicine ER -