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Long-term impact of pneumococcal polysaccharide vaccination on nasopharyngeal carriage in children previously vaccinated with various pneumococcal conjugate vaccine regimes.
Vaccine. 2015 Oct 13; 33(42):5708-5714.V

Abstract

Previously, the Fiji Pneumococcal Project (FiPP) evaluated reduced dose immunization schedules that incorporated pneumococcal protein conjugate and/or polysaccharide vaccine (PCV7 and 23vPPV, respectively). Immune hyporesponsiveness was observed in children vaccinated with 23vPPV at 12 months of age compared with children who did not receive 23vPPV. Here we assess the long-term impact of 23vPPV vaccination on nasopharyngeal carriage rates and densities of Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus and Moraxella catarrhalis. Nasopharyngeal swabs (n=194) were obtained from healthy children who participated in FiPP (now aged 5-7 years). S. pneumoniae were isolated and identified by standard culture-based methods, and serotyped using latex agglutination and the Quellung reaction. Carriage rates and densities of S. pneumoniae, H. influenzae, S. aureus and M. catarrhalis were determined using real-time quantitative PCR. There were no differences in the rate or density of S. pneumoniae, H. influenzae or M. catarrhalis carriage by PCV7 dose or 23vPPV vaccination in the vaccinated participants overall. However, differences were observed between the two main ethnic groups: Fijian children of Indian descent (Indo-Fijian) were less likely to carry S. pneumoniae, H. influenzae and M. catarrhalis, and there was evidence of a higher carriage rate of S. aureus compared with indigenous Fijian (iTaukei) children. Polysaccharide vaccination appeared to have effects that varied between ethnic groups, with 23vPPV vaccination associated with a higher carriage rate of S. aureus in iTaukei children, while there was a lower carriage rate of S. pneumoniae associated with 23vPPV vaccination in Indo-Fijian children. Overall, polysaccharide vaccination had no long-term impact on pneumococcal carriage, but may have impacted on S. aureus carriage and have varying effects in ethnic groups, suggesting current WHO vaccine schedule recommendations against the use of 23vPPV in children under two years of age are appropriate.

Authors+Show Affiliations

Pneumococcal Research, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, VIC, Australia; Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.Pneumococcal Research, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, VIC, Australia.Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia; Menzies School of Health Research, Darwin, NT, Australia.Clinical Epidemiology & Biostatistics Unit, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, VIC, Australia.Center for Quantitative Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore; Department of International Health, University of Tampere, Tampere, Finland.Ministry of Health, Suva, Fiji.Pneumococcal Research, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, VIC, Australia; Centre for International Child Health, Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.Pneumococcal Research, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, VIC, Australia; London School of Hygiene and Tropical Medicine, London, UK.Pneumococcal Research, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, VIC, Australia; Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia; Allergy and Immune Disorders, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, VIC, Australia.Pneumococcal Research, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, VIC, Australia; Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, Australia. Electronic address: catherine.satzke@mcri.edu.au.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26232540

Citation

Boelsen, Laura K., et al. "Long-term Impact of Pneumococcal Polysaccharide Vaccination On Nasopharyngeal Carriage in Children Previously Vaccinated With Various Pneumococcal Conjugate Vaccine Regimes." Vaccine, vol. 33, no. 42, 2015, pp. 5708-5714.
Boelsen LK, Dunne EM, Lamb KE, et al. Long-term impact of pneumococcal polysaccharide vaccination on nasopharyngeal carriage in children previously vaccinated with various pneumococcal conjugate vaccine regimes. Vaccine. 2015;33(42):5708-5714.
Boelsen, L. K., Dunne, E. M., Lamb, K. E., Bright, K., Cheung, Y. B., Tikoduadua, L., Russell, F. M., Mulholland, E. K., Licciardi, P. V., & Satzke, C. (2015). Long-term impact of pneumococcal polysaccharide vaccination on nasopharyngeal carriage in children previously vaccinated with various pneumococcal conjugate vaccine regimes. Vaccine, 33(42), 5708-5714. https://doi.org/10.1016/j.vaccine.2015.07.059
Boelsen LK, et al. Long-term Impact of Pneumococcal Polysaccharide Vaccination On Nasopharyngeal Carriage in Children Previously Vaccinated With Various Pneumococcal Conjugate Vaccine Regimes. Vaccine. 2015 Oct 13;33(42):5708-5714. PubMed PMID: 26232540.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term impact of pneumococcal polysaccharide vaccination on nasopharyngeal carriage in children previously vaccinated with various pneumococcal conjugate vaccine regimes. AU - Boelsen,Laura K, AU - Dunne,Eileen M, AU - Lamb,Karen E, AU - Bright,Kathryn, AU - Cheung,Yin Bun, AU - Tikoduadua,Lisi, AU - Russell,Fiona M, AU - Mulholland,E Kim, AU - Licciardi,Paul V, AU - Satzke,Catherine, Y1 - 2015/07/29/ PY - 2015/03/30/received PY - 2015/07/03/revised PY - 2015/07/20/accepted PY - 2015/8/2/entrez PY - 2015/8/2/pubmed PY - 2016/7/21/medline KW - Ethnicity KW - Nasopharyngeal carriage KW - Pneumococcal conjugate vaccine KW - Pneumococcal polysaccharide vaccine KW - Staphylococcus aureus KW - Streptococcus pneumoniae SP - 5708 EP - 5714 JF - Vaccine JO - Vaccine VL - 33 IS - 42 N2 - Previously, the Fiji Pneumococcal Project (FiPP) evaluated reduced dose immunization schedules that incorporated pneumococcal protein conjugate and/or polysaccharide vaccine (PCV7 and 23vPPV, respectively). Immune hyporesponsiveness was observed in children vaccinated with 23vPPV at 12 months of age compared with children who did not receive 23vPPV. Here we assess the long-term impact of 23vPPV vaccination on nasopharyngeal carriage rates and densities of Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus and Moraxella catarrhalis. Nasopharyngeal swabs (n=194) were obtained from healthy children who participated in FiPP (now aged 5-7 years). S. pneumoniae were isolated and identified by standard culture-based methods, and serotyped using latex agglutination and the Quellung reaction. Carriage rates and densities of S. pneumoniae, H. influenzae, S. aureus and M. catarrhalis were determined using real-time quantitative PCR. There were no differences in the rate or density of S. pneumoniae, H. influenzae or M. catarrhalis carriage by PCV7 dose or 23vPPV vaccination in the vaccinated participants overall. However, differences were observed between the two main ethnic groups: Fijian children of Indian descent (Indo-Fijian) were less likely to carry S. pneumoniae, H. influenzae and M. catarrhalis, and there was evidence of a higher carriage rate of S. aureus compared with indigenous Fijian (iTaukei) children. Polysaccharide vaccination appeared to have effects that varied between ethnic groups, with 23vPPV vaccination associated with a higher carriage rate of S. aureus in iTaukei children, while there was a lower carriage rate of S. pneumoniae associated with 23vPPV vaccination in Indo-Fijian children. Overall, polysaccharide vaccination had no long-term impact on pneumococcal carriage, but may have impacted on S. aureus carriage and have varying effects in ethnic groups, suggesting current WHO vaccine schedule recommendations against the use of 23vPPV in children under two years of age are appropriate. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/26232540/Long_term_impact_of_pneumococcal_polysaccharide_vaccination_on_nasopharyngeal_carriage_in_children_previously_vaccinated_with_various_pneumococcal_conjugate_vaccine_regimes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(15)01020-8 DB - PRIME DP - Unbound Medicine ER -