Tags

Type your tag names separated by a space and hit enter

Examining drug hydrophobicity in continuous wet granulation within a twin screw extruder.
Int J Pharm. 2015 Dec 30; 496(1):3-11.IJ

Abstract

The influence of active pharmaceutical ingredient (API) hydrophobicity on continuous wet granulation was studied in twin screw granulation utilizing foamed binder delivery. The APIs examined were caffeine, acetaminophen, ibuprofen and griseofulvin and the drug load was maintained constant at 15 wt%. In order to understand the impact of these APIs on the granulation process, API and binder distribution, particle size, porosity, and fracture strength were analyzed on samples collected along the screw length. It was found that the API and binder distributions were uniform along the screws regardless of the hydrophobicity of the formulation, in contrast to literature results with liquid injection. The absence of de-mixing of the hydrophobic ingredient was hypothesized to be a result of the high spread-to-soak ratio of a foamed binder that 'cages' those particles within the mass of local hydrophilic solids.

Authors+Show Affiliations

Dow Pharma & Food Solutions, The Dow Chemical Company, Midland, Michigan, USA.Dow Pharma & Food Solutions, The Dow Chemical Company, Midland, Michigan, USA. Electronic address: mthomps@mcmaster.ca.Dow Pharma & Food Solutions, The Dow Chemical Company, Midland, Michigan, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26232701

Citation

Li, H, et al. "Examining Drug Hydrophobicity in Continuous Wet Granulation Within a Twin Screw Extruder." International Journal of Pharmaceutics, vol. 496, no. 1, 2015, pp. 3-11.
Li H, Thompson MR, O'Donnell KP. Examining drug hydrophobicity in continuous wet granulation within a twin screw extruder. Int J Pharm. 2015;496(1):3-11.
Li, H., Thompson, M. R., & O'Donnell, K. P. (2015). Examining drug hydrophobicity in continuous wet granulation within a twin screw extruder. International Journal of Pharmaceutics, 496(1), 3-11. https://doi.org/10.1016/j.ijpharm.2015.07.070
Li H, Thompson MR, O'Donnell KP. Examining Drug Hydrophobicity in Continuous Wet Granulation Within a Twin Screw Extruder. Int J Pharm. 2015 Dec 30;496(1):3-11. PubMed PMID: 26232701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Examining drug hydrophobicity in continuous wet granulation within a twin screw extruder. AU - Li,H, AU - Thompson,M R, AU - O'Donnell,K P, Y1 - 2015/07/29/ PY - 2015/02/14/received PY - 2015/07/24/revised PY - 2015/07/27/accepted PY - 2015/8/2/entrez PY - 2015/8/2/pubmed PY - 2016/9/16/medline KW - Binder distribution KW - Foam KW - Hydrophobicity KW - Twin screw granulation SP - 3 EP - 11 JF - International journal of pharmaceutics JO - Int J Pharm VL - 496 IS - 1 N2 - The influence of active pharmaceutical ingredient (API) hydrophobicity on continuous wet granulation was studied in twin screw granulation utilizing foamed binder delivery. The APIs examined were caffeine, acetaminophen, ibuprofen and griseofulvin and the drug load was maintained constant at 15 wt%. In order to understand the impact of these APIs on the granulation process, API and binder distribution, particle size, porosity, and fracture strength were analyzed on samples collected along the screw length. It was found that the API and binder distributions were uniform along the screws regardless of the hydrophobicity of the formulation, in contrast to literature results with liquid injection. The absence of de-mixing of the hydrophobic ingredient was hypothesized to be a result of the high spread-to-soak ratio of a foamed binder that 'cages' those particles within the mass of local hydrophilic solids. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/26232701/Examining_drug_hydrophobicity_in_continuous_wet_granulation_within_a_twin_screw_extruder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(15)30088-0 DB - PRIME DP - Unbound Medicine ER -