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Rapid elimination of Carboxy-THC in a cohort of chronic cannabis users.
Int J Legal Med. 2016 Jan; 130(1):147-52.IJ

Abstract

Urinary 11-nor-Δ(9)-tetrahydrocannabinol-9-carboxylic acid (Carboxy-THC) concentrations, normalised to creatinine output, have been demonstrated to be a useful tool in the interpretation of the results of a series of urine tests for cannabis. These tests, often termed historical data, can be used to identify potential chronic cannabis users who may present occupational health and safety risks within the workplace. Conversely, the data can also be used to support employee claims of previous regular, rather than recent, cannabis use. This study aimed at examining the mean elimination of Carboxy-THC in 37 chronic users undergoing voluntary abstinence over a 2-week period. Urine specimens were collected prior to the study and after 1 and 2 weeks of abstinence. Carboxy-THC levels in urine were measured by gas chromatography-mass spectrometry (GC-MS) following alkaline hydrolysis, organic solvent extraction and derivatisation to form its pentafluoropropionic derivative. The creatinine-normalised Carboxy-THC concentrations declined rapidly over the 2 weeks of abstinence period and the majority of chronic cannabis users (73%) reduced their urinary Carboxy-THC levels to below the 15-μg/L confirmatory cutoff within that time. The study further highlights the value of historical urinary Carboxy-THC data as a means of identifying potential occupational health and safety risks among chronic cannabis users.

Authors+Show Affiliations

Centre for Forensic Science, University of Technology Sydney (UTS), Broadway, Sydney, NSW, 2007, Australia. National Cannabis Prevention and Information Centre, UNSW Medicine, Sydney, NSW, 2052, Australia.Centre for Forensic Science, University of Technology Sydney (UTS), Broadway, Sydney, NSW, 2007, Australia.National Cannabis Prevention and Information Centre, UNSW Medicine, Sydney, NSW, 2052, Australia.National Cannabis Prevention and Information Centre, UNSW Medicine, Sydney, NSW, 2052, Australia.Centre for Forensic Science, University of Technology Sydney (UTS), Broadway, Sydney, NSW, 2007, Australia. shanlin.fu@uts.edu.au.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26233612

Citation

Lewis, John, et al. "Rapid Elimination of Carboxy-THC in a Cohort of Chronic Cannabis Users." International Journal of Legal Medicine, vol. 130, no. 1, 2016, pp. 147-52.
Lewis J, Molnar A, Allsop D, et al. Rapid elimination of Carboxy-THC in a cohort of chronic cannabis users. Int J Legal Med. 2016;130(1):147-52.
Lewis, J., Molnar, A., Allsop, D., Copeland, J., & Fu, S. (2016). Rapid elimination of Carboxy-THC in a cohort of chronic cannabis users. International Journal of Legal Medicine, 130(1), 147-52. https://doi.org/10.1007/s00414-015-1241-z
Lewis J, et al. Rapid Elimination of Carboxy-THC in a Cohort of Chronic Cannabis Users. Int J Legal Med. 2016;130(1):147-52. PubMed PMID: 26233612.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rapid elimination of Carboxy-THC in a cohort of chronic cannabis users. AU - Lewis,John, AU - Molnar,Anna, AU - Allsop,David, AU - Copeland,Jan, AU - Fu,Shanlin, Y1 - 2015/08/02/ PY - 2015/05/30/received PY - 2015/07/23/accepted PY - 2015/8/3/entrez PY - 2015/8/4/pubmed PY - 2016/10/13/medline KW - Cannabis KW - Carboxy-THC KW - THCCOOH KW - Urine drug testing SP - 147 EP - 52 JF - International journal of legal medicine JO - Int. J. Legal Med. VL - 130 IS - 1 N2 - Urinary 11-nor-Δ(9)-tetrahydrocannabinol-9-carboxylic acid (Carboxy-THC) concentrations, normalised to creatinine output, have been demonstrated to be a useful tool in the interpretation of the results of a series of urine tests for cannabis. These tests, often termed historical data, can be used to identify potential chronic cannabis users who may present occupational health and safety risks within the workplace. Conversely, the data can also be used to support employee claims of previous regular, rather than recent, cannabis use. This study aimed at examining the mean elimination of Carboxy-THC in 37 chronic users undergoing voluntary abstinence over a 2-week period. Urine specimens were collected prior to the study and after 1 and 2 weeks of abstinence. Carboxy-THC levels in urine were measured by gas chromatography-mass spectrometry (GC-MS) following alkaline hydrolysis, organic solvent extraction and derivatisation to form its pentafluoropropionic derivative. The creatinine-normalised Carboxy-THC concentrations declined rapidly over the 2 weeks of abstinence period and the majority of chronic cannabis users (73%) reduced their urinary Carboxy-THC levels to below the 15-μg/L confirmatory cutoff within that time. The study further highlights the value of historical urinary Carboxy-THC data as a means of identifying potential occupational health and safety risks among chronic cannabis users. SN - 1437-1596 UR - https://www.unboundmedicine.com/medline/citation/26233612/Rapid_elimination_of_Carboxy_THC_in_a_cohort_of_chronic_cannabis_users_ L2 - https://dx.doi.org/10.1007/s00414-015-1241-z DB - PRIME DP - Unbound Medicine ER -