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Aberrant serum polyunsaturated fatty acids profile is relevant with acute coronary syndrome.
Heart Vessels. 2016 Aug; 31(8):1209-17.HV

Abstract

Although a robust relationship between aberrant serum polyunsaturated fatty acids (PUFAs) profile and coronary artery disease (CAD) has been reported, the details concerning the association between aberrant PUFAs profile and clinical feature of CAD are not fully discovered. Therefore, we investigated the relationship between serum PUFAs and clinical profiles in CAD patients. We classified 595 consecutive CAD patients, who underwent coronary angiography into 3 groups according to the clinical profiles of CAD (group A: early phase ACS, n = 96; group B: stable CAD with previous history of ACS, n = 259; group C: stable CAD without previous history of ACS, n = 240) and measured serum n-3 [eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA)] and n-6 [arachidonic acid (AA)] PUFAs. Serum EPA, DHA, and EPA/AA ratio were significantly low in the order of group A < B < C [EPA; 48.1 (34.1-60.3) μg/ml, 61.7 (41.2-94.5) μg/ml, and 74.4 (52.7-104.9) μg/ml, DHA; 113.1 (92.8-135.1) μg/ml, 125.8 (100.4-167.2) μg/ml, and 140.1 (114.7-177.0) μg/ml, EPA/AA ratio; 0.31 (0.22-0.45), 0.39 (0.26-0.62), and 0.44 (0.31-0.69), medians with interquartile range, p < 0.01]. Multiple regression analysis revealed that EPA (p = 0.009) and EPA/AA ratio (p = 0.023), but not DHA and DHA/AA ratio, were negatively associated with clinical profiles of ACS in CAD patients. Significant correlation was not observed between PUFAs profile and severity of coronary stenosis. Low serum EPA and EPA/AA ratio correlates with clinical profiles of ACS in patients with CAD, regardless of the extent and severity of coronary artery stenosis.

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Authors+Show Affiliations

Sakamoto A
Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine; 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan. Department of Cardiology, Shizuoka City Shizuoka Hospital; 10-93 Otemachi, Aoi-ku, Shizuoka, 420-8630, Japan.
Saotome M
Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine; 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan. msaotome@hama-med.ac.jp.
Hosoya N
Department of Cardiology, Shizuoka City Shizuoka Hospital; 10-93 Otemachi, Aoi-ku, Shizuoka, 420-8630, Japan.
Kageyama S
Department of Cardiology, Shizuoka City Shizuoka Hospital; 10-93 Otemachi, Aoi-ku, Shizuoka, 420-8630, Japan.
Yoshizaki T
Department of Cardiology, Shizuoka City Shizuoka Hospital; 10-93 Otemachi, Aoi-ku, Shizuoka, 420-8630, Japan.
Takeuchi R
Department of Cardiology, Shizuoka City Shizuoka Hospital; 10-93 Otemachi, Aoi-ku, Shizuoka, 420-8630, Japan.
Murata K
Department of Cardiology, Shizuoka City Shizuoka Hospital; 10-93 Otemachi, Aoi-ku, Shizuoka, 420-8630, Japan.
Nawada R
Department of Cardiology, Shizuoka City Shizuoka Hospital; 10-93 Otemachi, Aoi-ku, Shizuoka, 420-8630, Japan.
Onodera T
Department of Cardiology, Shizuoka City Shizuoka Hospital; 10-93 Otemachi, Aoi-ku, Shizuoka, 420-8630, Japan.
Takizawa A
Department of Cardiology, Shizuoka City Shizuoka Hospital; 10-93 Otemachi, Aoi-ku, Shizuoka, 420-8630, Japan.
Satoh H
Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine; 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.
Hayashi H
Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine; 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.

MeSH

Acute Coronary SyndromeAgedAged, 80 and overArachidonic AcidCoronary AngiographyCoronary Artery DiseaseDocosahexaenoic AcidsEicosapentaenoic AcidFemaleHumansJapanMaleMiddle AgedRegression AnalysisRetrospective StudiesSeverity of Illness Index

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26233644

Citation

Sakamoto, Atsushi, et al. "Aberrant Serum Polyunsaturated Fatty Acids Profile Is Relevant With Acute Coronary Syndrome." Heart and Vessels, vol. 31, no. 8, 2016, pp. 1209-17.
Sakamoto A, Saotome M, Hosoya N, et al. Aberrant serum polyunsaturated fatty acids profile is relevant with acute coronary syndrome. Heart Vessels. 2016;31(8):1209-17.
Sakamoto, A., Saotome, M., Hosoya, N., Kageyama, S., Yoshizaki, T., Takeuchi, R., Murata, K., Nawada, R., Onodera, T., Takizawa, A., Satoh, H., & Hayashi, H. (2016). Aberrant serum polyunsaturated fatty acids profile is relevant with acute coronary syndrome. Heart and Vessels, 31(8), 1209-17. https://doi.org/10.1007/s00380-015-0721-x
Sakamoto A, et al. Aberrant Serum Polyunsaturated Fatty Acids Profile Is Relevant With Acute Coronary Syndrome. Heart Vessels. 2016;31(8):1209-17. PubMed PMID: 26233644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aberrant serum polyunsaturated fatty acids profile is relevant with acute coronary syndrome. AU - Sakamoto,Atsushi, AU - Saotome,Masao, AU - Hosoya,Natsuko, AU - Kageyama,Shigetaka, AU - Yoshizaki,Toru, AU - Takeuchi,Ryosuke, AU - Murata,Koichiro, AU - Nawada,Ryuzo, AU - Onodera,Tomoya, AU - Takizawa,Akinori, AU - Satoh,Hiroshi, AU - Hayashi,Hideharu, Y1 - 2015/08/02/ PY - 2015/03/23/received PY - 2015/07/24/accepted PY - 2015/8/3/entrez PY - 2015/8/4/pubmed PY - 2017/4/19/medline KW - Acute coronary syndrome KW - Arachidonic acid KW - Coronary artery disease KW - Docosahexaenoic acid KW - Eicosapentaenoic acid KW - n-3 polyunsaturated fatty acid KW - n-6 polyunsaturated fatty acid SP - 1209 EP - 17 JF - Heart and vessels JO - Heart Vessels VL - 31 IS - 8 N2 - Although a robust relationship between aberrant serum polyunsaturated fatty acids (PUFAs) profile and coronary artery disease (CAD) has been reported, the details concerning the association between aberrant PUFAs profile and clinical feature of CAD are not fully discovered. Therefore, we investigated the relationship between serum PUFAs and clinical profiles in CAD patients. We classified 595 consecutive CAD patients, who underwent coronary angiography into 3 groups according to the clinical profiles of CAD (group A: early phase ACS, n = 96; group B: stable CAD with previous history of ACS, n = 259; group C: stable CAD without previous history of ACS, n = 240) and measured serum n-3 [eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA)] and n-6 [arachidonic acid (AA)] PUFAs. Serum EPA, DHA, and EPA/AA ratio were significantly low in the order of group A < B < C [EPA; 48.1 (34.1-60.3) μg/ml, 61.7 (41.2-94.5) μg/ml, and 74.4 (52.7-104.9) μg/ml, DHA; 113.1 (92.8-135.1) μg/ml, 125.8 (100.4-167.2) μg/ml, and 140.1 (114.7-177.0) μg/ml, EPA/AA ratio; 0.31 (0.22-0.45), 0.39 (0.26-0.62), and 0.44 (0.31-0.69), medians with interquartile range, p < 0.01]. Multiple regression analysis revealed that EPA (p = 0.009) and EPA/AA ratio (p = 0.023), but not DHA and DHA/AA ratio, were negatively associated with clinical profiles of ACS in CAD patients. Significant correlation was not observed between PUFAs profile and severity of coronary stenosis. Low serum EPA and EPA/AA ratio correlates with clinical profiles of ACS in patients with CAD, regardless of the extent and severity of coronary artery stenosis. SN - 1615-2573 UR - https://www.unboundmedicine.com/medline/citation/26233644/Aberrant_serum_polyunsaturated_fatty_acids_profile_is_relevant_with_acute_coronary_syndrome_ DB - PRIME DP - Unbound Medicine ER -