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Beneficial effects of vitamin E supplementation against the oxidative stress on Cylindrospermopsin-exposed tilapia (Oreochromis niloticus).
Toxicon. 2015 Sep 15; 104:34-42.T

Abstract

Cylindrospermopsin (CYN) is known to produce changes in some oxidative stress biomarkers in fish acutely and subchronically exposed to the toxin. The present study investigated the effects of vitamin E supplementation against the oxidative stress induced by pure CYN in tilapia (Oreochromis niloticus). Fish were pretreated with 700 mg vitamin E/kg fish body weight (bw)/day for 7 days by oral route, and on day seven, they received a single oral dose of 400 μg pure CYN/kg fish bw, and were killed after 24 h. The biomarkers evaluated included lipid peroxidation (LPO), protein and DNA oxidation, glutathione-S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT) and γ-glutamyl-cysteine synthetase (γ-GCS) activities, and ratio of reduced glutathione-oxidized glutathione (GSH/GSSG). This is the first study showing that vitamin E supplementation is effective at reducing the toxicity induced by CYN, recovering the biomarkers assayed to basal levels. Therefore, vitamin E can be considered a useful chemoprotectant that reduces hepatic and renal oxidative stress and can be used in the prophylaxis and treatment of CYN-related intoxication in fish.

Authors+Show Affiliations

Area of Toxicology, Faculty of Pharmacy, University of Sevilla, Spain. Electronic address: rguzman1@us.es.Area of Toxicology, Faculty of Pharmacy, University of Sevilla, Spain.Stomatology Department, School of Dentistry, University of Sevilla, Spain.Area of Toxicology, Faculty of Pharmacy, University of Sevilla, Spain.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26235908

Citation

Guzmán-Guillén, Remedios, et al. "Beneficial Effects of Vitamin E Supplementation Against the Oxidative Stress On Cylindrospermopsin-exposed Tilapia (Oreochromis Niloticus)." Toxicon : Official Journal of the International Society On Toxinology, vol. 104, 2015, pp. 34-42.
Guzmán-Guillén R, Prieto Ortega AI, Martín-Caméan A, et al. Beneficial effects of vitamin E supplementation against the oxidative stress on Cylindrospermopsin-exposed tilapia (Oreochromis niloticus). Toxicon. 2015;104:34-42.
Guzmán-Guillén, R., Prieto Ortega, A. I., Martín-Caméan, A., & Cameán, A. M. (2015). Beneficial effects of vitamin E supplementation against the oxidative stress on Cylindrospermopsin-exposed tilapia (Oreochromis niloticus). Toxicon : Official Journal of the International Society On Toxinology, 104, 34-42. https://doi.org/10.1016/j.toxicon.2015.07.336
Guzmán-Guillén R, et al. Beneficial Effects of Vitamin E Supplementation Against the Oxidative Stress On Cylindrospermopsin-exposed Tilapia (Oreochromis Niloticus). Toxicon. 2015 Sep 15;104:34-42. PubMed PMID: 26235908.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beneficial effects of vitamin E supplementation against the oxidative stress on Cylindrospermopsin-exposed tilapia (Oreochromis niloticus). AU - Guzmán-Guillén,Remedios, AU - Prieto Ortega,Ana I, AU - Martín-Caméan,Ana, AU - Cameán,Ana M, Y1 - 2015/07/31/ PY - 2015/05/29/received PY - 2015/07/21/revised PY - 2015/07/23/accepted PY - 2015/8/4/entrez PY - 2015/8/4/pubmed PY - 2016/7/21/medline KW - Cylindrospermopsin KW - Fish KW - Oreochromis niloticus KW - Oxidative stress KW - Vitamin E SP - 34 EP - 42 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 104 N2 - Cylindrospermopsin (CYN) is known to produce changes in some oxidative stress biomarkers in fish acutely and subchronically exposed to the toxin. The present study investigated the effects of vitamin E supplementation against the oxidative stress induced by pure CYN in tilapia (Oreochromis niloticus). Fish were pretreated with 700 mg vitamin E/kg fish body weight (bw)/day for 7 days by oral route, and on day seven, they received a single oral dose of 400 μg pure CYN/kg fish bw, and were killed after 24 h. The biomarkers evaluated included lipid peroxidation (LPO), protein and DNA oxidation, glutathione-S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT) and γ-glutamyl-cysteine synthetase (γ-GCS) activities, and ratio of reduced glutathione-oxidized glutathione (GSH/GSSG). This is the first study showing that vitamin E supplementation is effective at reducing the toxicity induced by CYN, recovering the biomarkers assayed to basal levels. Therefore, vitamin E can be considered a useful chemoprotectant that reduces hepatic and renal oxidative stress and can be used in the prophylaxis and treatment of CYN-related intoxication in fish. SN - 1879-3150 UR - https://www.unboundmedicine.com/medline/citation/26235908/Beneficial_effects_of_vitamin_E_supplementation_against_the_oxidative_stress_on_Cylindrospermopsin_exposed_tilapia__Oreochromis_niloticus__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-0101(15)30024-6 DB - PRIME DP - Unbound Medicine ER -