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Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans.
Oxid Med Cell Longev. 2015; 2015:740162.OM

Abstract

Carqueja (Baccharis trimera) is a native plant found throughout South America. Several studies have shown that Carqueja has antioxidant activity in vitro, as well as anti-inflammatory, antidiabetic, analgesic, antihepatotoxic, and antimutagenic properties. However, studies regarding its antioxidant potential in vivo are limited. In this study, we used Caenorhabditis elegans as a model to examine the antioxidant effects of a Carqueja hydroalcoholic extract (CHE) on stress resistance and lifespan and to investigate whether CHE has a protective effect in a C. elegans model for Alzheimer's disease. Here, we show for the first time, using in vivo assays, that CHE treatment improved oxidative stress resistance by increasing survival rate and by reducing ROS levels under oxidative stress conditions independently of the stress-related signaling pathways (p38, JNK, and ERK) and transcription factors (SKN-1/Nrf and DAF-16/Foxo) tested here. CHE treatment also increased the defenses against β-amyloid toxicity in C. elegans, in part by increasing proteasome activity and the expression of two heat shock protein genes. Our findings suggest a potential neuroprotective use for Carqueja, supporting the idea that dietary antioxidants are a promising approach to boost the defensive systems against stress and neurodegeneration.

Authors+Show Affiliations

Núcleo de Pesquisa em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Brazil.Núcleo de Pesquisa em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Brazil.Núcleo de Pesquisa em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Brazil.Núcleo de Pesquisa em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Brazil.Núcleo de Pesquisa em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Brazil.Departamento de Biodiversidade, Evolução e Meio Ambiente, Universidade Federal de Ouro Preto, Ouro Preto, Brazil.Núcleo de Pesquisa em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Brazil ; Departamento de Alimentos, Universidade Federal de Ouro Preto, Ouro Preto, Brazil.Núcleo de Pesquisa em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Brazil ; Departamento de Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Brazil.Núcleo de Pesquisa em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Brazil ; Departamento de Biodiversidade, Evolução e Meio Ambiente, Universidade Federal de Ouro Preto, Ouro Preto, Brazil ; Departamento de Biologia Celular e Genética, Universidade Federal do Rio Grande do Norte, Natal, Brazil.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26236426

Citation

Paiva, Franciny Aparecida, et al. "Carqueja (Baccharis Trimera) Protects Against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis Elegans." Oxidative Medicine and Cellular Longevity, vol. 2015, 2015, p. 740162.
Paiva FA, Bonomo Lde F, Boasquivis PF, et al. Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev. 2015;2015:740162.
Paiva, F. A., Bonomo, L. d. e. . F., Boasquivis, P. F., de Paula, I. T., Guerra, J. F., Leal, W. M., Silva, M. E., Pedrosa, M. L., & Oliveira, R. d. e. . P. (2015). Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxidative Medicine and Cellular Longevity, 2015, 740162. https://doi.org/10.1155/2015/740162
Paiva FA, et al. Carqueja (Baccharis Trimera) Protects Against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis Elegans. Oxid Med Cell Longev. 2015;2015:740162. PubMed PMID: 26236426.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. AU - Paiva,Franciny Aparecida, AU - Bonomo,Larissa de Freitas, AU - Boasquivis,Patrícia Ferreira, AU - de Paula,Igor Thadeu Borges Raposo, AU - Guerra,Joyce Ferreira da Costa, AU - Leal,Wagney Mendes, AU - Silva,Marcelo Eustáquio, AU - Pedrosa,Maria Lúcia, AU - Oliveira,Riva de Paula, Y1 - 2015/07/07/ PY - 2014/09/22/received PY - 2015/01/19/revised PY - 2015/02/02/accepted PY - 2015/8/4/entrez PY - 2015/8/4/pubmed PY - 2016/4/9/medline SP - 740162 EP - 740162 JF - Oxidative medicine and cellular longevity JO - Oxid Med Cell Longev VL - 2015 N2 - Carqueja (Baccharis trimera) is a native plant found throughout South America. Several studies have shown that Carqueja has antioxidant activity in vitro, as well as anti-inflammatory, antidiabetic, analgesic, antihepatotoxic, and antimutagenic properties. However, studies regarding its antioxidant potential in vivo are limited. In this study, we used Caenorhabditis elegans as a model to examine the antioxidant effects of a Carqueja hydroalcoholic extract (CHE) on stress resistance and lifespan and to investigate whether CHE has a protective effect in a C. elegans model for Alzheimer's disease. Here, we show for the first time, using in vivo assays, that CHE treatment improved oxidative stress resistance by increasing survival rate and by reducing ROS levels under oxidative stress conditions independently of the stress-related signaling pathways (p38, JNK, and ERK) and transcription factors (SKN-1/Nrf and DAF-16/Foxo) tested here. CHE treatment also increased the defenses against β-amyloid toxicity in C. elegans, in part by increasing proteasome activity and the expression of two heat shock protein genes. Our findings suggest a potential neuroprotective use for Carqueja, supporting the idea that dietary antioxidants are a promising approach to boost the defensive systems against stress and neurodegeneration. SN - 1942-0994 UR - https://www.unboundmedicine.com/medline/citation/26236426/Carqueja__Baccharis_trimera__Protects_against_Oxidative_Stress_and_β_Amyloid_Induced_Toxicity_in_Caenorhabditis_elegans_ L2 - https://dx.doi.org/10.1155/2015/740162 DB - PRIME DP - Unbound Medicine ER -