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High School Diet and Risk of Crohn's Disease and Ulcerative Colitis.

Abstract

BACKGROUND

Diet may play an important role in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC); yet, there are few prospective studies of dietary factors. None have examined the association between adolescent diet and risk of inflammatory bowel diseases (CD and UC).

METHODS

This study included women enrolled in Nurses' Health Study II who completed a validated high school dietary questionnaire in 1998. We examined the effect of dietary patterns (prudent or Western diet) and individual components of each patterns. We documented incident cases of CD and UC through 2011 based on physician review of medical records and used Cox proportional hazards models adjusting for confounders to estimate hazard ratios and confidence intervals for CD and UC.

RESULTS

Over 763,229 person-years of follow-up, we identified 70 incident cases of CD and 103 cases of UC. Compared with women in the lowest quartile of a prudent diet score (characterized by greater intake of fruits, vegetables, and fish), women in the highest quartile had a 53% lower risk of CD (hazard ratio, 0.47; 95% confidence interval, 0.23-0.98; P trend = 0.04). Specifically, greater intake of fish (P trend = 0.01) and fiber (P trend = 0.06) were associated with lower risk of CD. In contrast, Western diet score was not associated with risk of CD. Neither dietary patterns nor individual food or nutrient groups was associated with UC.

CONCLUSIONS

Adolescent diet is associated with risk of CD, but not UC, offering insights into disease pathogenesis.

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    *Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; †Departments of Nutrition and Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts; ‡Division of Gastroenterology and Nutrition, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts; §Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany; and ‖Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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    Source

    Inflammatory bowel diseases 21:10 2015 Oct pg 2311-9

    MeSH

    Adolescent
    Adult
    Colitis, Ulcerative
    Crohn Disease
    Diet
    Diet Surveys
    Dietary Fiber
    Female
    Fruit
    Humans
    Incidence
    Proportional Hazards Models
    Prospective Studies
    Risk Assessment
    Risk Factors
    Schools
    Seafood
    Vegetables
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26236952

    Citation

    Ananthakrishnan, Ashwin N., et al. "High School Diet and Risk of Crohn's Disease and Ulcerative Colitis." Inflammatory Bowel Diseases, vol. 21, no. 10, 2015, pp. 2311-9.
    Ananthakrishnan AN, Khalili H, Song M, et al. High School Diet and Risk of Crohn's Disease and Ulcerative Colitis. Inflamm Bowel Dis. 2015;21(10):2311-9.
    Ananthakrishnan, A. N., Khalili, H., Song, M., Higuchi, L. M., Richter, J. M., Nimptsch, K., ... Chan, A. T. (2015). High School Diet and Risk of Crohn's Disease and Ulcerative Colitis. Inflammatory Bowel Diseases, 21(10), pp. 2311-9. doi:10.1097/MIB.0000000000000501.
    Ananthakrishnan AN, et al. High School Diet and Risk of Crohn's Disease and Ulcerative Colitis. Inflamm Bowel Dis. 2015;21(10):2311-9. PubMed PMID: 26236952.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - High School Diet and Risk of Crohn's Disease and Ulcerative Colitis. AU - Ananthakrishnan,Ashwin N, AU - Khalili,Hamed, AU - Song,Mingyang, AU - Higuchi,Leslie M, AU - Richter,James M, AU - Nimptsch,Katharina, AU - Wu,Kana, AU - Chan,Andrew T, PY - 2015/8/4/entrez PY - 2015/8/4/pubmed PY - 2016/6/29/medline SP - 2311 EP - 9 JF - Inflammatory bowel diseases JO - Inflamm. Bowel Dis. VL - 21 IS - 10 N2 - BACKGROUND: Diet may play an important role in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC); yet, there are few prospective studies of dietary factors. None have examined the association between adolescent diet and risk of inflammatory bowel diseases (CD and UC). METHODS: This study included women enrolled in Nurses' Health Study II who completed a validated high school dietary questionnaire in 1998. We examined the effect of dietary patterns (prudent or Western diet) and individual components of each patterns. We documented incident cases of CD and UC through 2011 based on physician review of medical records and used Cox proportional hazards models adjusting for confounders to estimate hazard ratios and confidence intervals for CD and UC. RESULTS: Over 763,229 person-years of follow-up, we identified 70 incident cases of CD and 103 cases of UC. Compared with women in the lowest quartile of a prudent diet score (characterized by greater intake of fruits, vegetables, and fish), women in the highest quartile had a 53% lower risk of CD (hazard ratio, 0.47; 95% confidence interval, 0.23-0.98; P trend = 0.04). Specifically, greater intake of fish (P trend = 0.01) and fiber (P trend = 0.06) were associated with lower risk of CD. In contrast, Western diet score was not associated with risk of CD. Neither dietary patterns nor individual food or nutrient groups was associated with UC. CONCLUSIONS: Adolescent diet is associated with risk of CD, but not UC, offering insights into disease pathogenesis. SN - 1536-4844 UR - https://www.unboundmedicine.com/medline/citation/26236952/High_School_Diet_and_Risk_of_Crohn's_Disease_and_Ulcerative_Colitis_ L2 - https://academic.oup.com/ibdjournal/article-lookup/doi/10.1097/MIB.0000000000000501 DB - PRIME DP - Unbound Medicine ER -