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Omental adipocyte hypertrophy relates to coenzyme Q10 redox state and lipid peroxidation in obese women.
J Lipid Res. 2015 Oct; 56(10):1985-92.JL

Abstract

Occurrence of oxidative stress in white adipose tissues contributes to its dysfunction and the development of obesity-related metabolic complications. Coenzyme Q10 (CoQ10) is the single lipophilic antioxidant synthesized in humans and is essential for electron transport during mitochondrial respiration. To understand the role of CoQ10 in adipose tissue physiology and dysfunction, the abundance of the oxidized and reduced (CoQ10red) isoforms of the CoQ10 were quantified in subcutaneous and omental adipose tissues of women covering the full range of BMI (from 21.5 to 53.2 kg/m(2)). Lean women displayed regional variations of CoQ10 redox state between the omental and subcutaneous depot, despite similar total content. Obese women had reduced CoQ10red concentrations in the omental depot, leading to increased CoQ10 redox state and higher levels of lipid hydroperoxide. Women with low omental CoQ10 content had greater visceral and subcutaneous adiposity, increased omental adipocyte diameter, and higher circulating interleukin-6 and C-reactive protein levels and were more insulin resistant. The associations between abdominal obesity-related cardiometabolic risk factors and CoQ10 content in the omental depot were abolished after adjustment for omental adipocyte diameter. This study shows that hypertrophic remodeling of visceral fat closely relates to depletion of CoQ10, lipid peroxidation, and inflammation.

Authors+Show Affiliations

Endocrinology and Nephrology Axis, Centre Hospitalier Universitaire de Québec, Québec, Canada Department of Medicine, Division of Endocrinology, Université de Sherbrooke, Québec, Canada.CNRS 5273, UMR STROMALab, Toulouse, France Université de Toulouse, UPS, Toulouse, France INSERM U1031, Toulouse, France EFS Pyrénées-Méditerranée, Toulouse, France.CNRS 5273, UMR STROMALab, Toulouse, France Université de Toulouse, UPS, Toulouse, France INSERM U1031, Toulouse, France EFS Pyrénées-Méditerranée, Toulouse, France.Department of Medicine, Division of Endocrinology, Université de Sherbrooke, Québec, Canada.Endocrinology and Nephrology Axis, Centre Hospitalier Universitaire de Québec, Québec, Canada.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26239051

Citation

Grenier-Larouche, Thomas, et al. "Omental Adipocyte Hypertrophy Relates to Coenzyme Q10 Redox State and Lipid Peroxidation in Obese Women." Journal of Lipid Research, vol. 56, no. 10, 2015, pp. 1985-92.
Grenier-Larouche T, Galinier A, Casteilla L, et al. Omental adipocyte hypertrophy relates to coenzyme Q10 redox state and lipid peroxidation in obese women. J Lipid Res. 2015;56(10):1985-92.
Grenier-Larouche, T., Galinier, A., Casteilla, L., Carpentier, A. C., & Tchernof, A. (2015). Omental adipocyte hypertrophy relates to coenzyme Q10 redox state and lipid peroxidation in obese women. Journal of Lipid Research, 56(10), 1985-92. https://doi.org/10.1194/jlr.P058578
Grenier-Larouche T, et al. Omental Adipocyte Hypertrophy Relates to Coenzyme Q10 Redox State and Lipid Peroxidation in Obese Women. J Lipid Res. 2015;56(10):1985-92. PubMed PMID: 26239051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omental adipocyte hypertrophy relates to coenzyme Q10 redox state and lipid peroxidation in obese women. AU - Grenier-Larouche,Thomas, AU - Galinier,Anne, AU - Casteilla,Louis, AU - Carpentier,André C, AU - Tchernof,André, Y1 - 2015/08/03/ PY - 2015/02/13/received PY - 2015/8/5/entrez PY - 2015/8/5/pubmed PY - 2016/8/5/medline KW - adipocytes KW - adipose tissue KW - antioxidant KW - body fat distribution KW - cardiometabolic risk factors KW - mitochondria KW - obesity KW - ubiquinol KW - ubiquinone SP - 1985 EP - 92 JF - Journal of lipid research JO - J Lipid Res VL - 56 IS - 10 N2 - Occurrence of oxidative stress in white adipose tissues contributes to its dysfunction and the development of obesity-related metabolic complications. Coenzyme Q10 (CoQ10) is the single lipophilic antioxidant synthesized in humans and is essential for electron transport during mitochondrial respiration. To understand the role of CoQ10 in adipose tissue physiology and dysfunction, the abundance of the oxidized and reduced (CoQ10red) isoforms of the CoQ10 were quantified in subcutaneous and omental adipose tissues of women covering the full range of BMI (from 21.5 to 53.2 kg/m(2)). Lean women displayed regional variations of CoQ10 redox state between the omental and subcutaneous depot, despite similar total content. Obese women had reduced CoQ10red concentrations in the omental depot, leading to increased CoQ10 redox state and higher levels of lipid hydroperoxide. Women with low omental CoQ10 content had greater visceral and subcutaneous adiposity, increased omental adipocyte diameter, and higher circulating interleukin-6 and C-reactive protein levels and were more insulin resistant. The associations between abdominal obesity-related cardiometabolic risk factors and CoQ10 content in the omental depot were abolished after adjustment for omental adipocyte diameter. This study shows that hypertrophic remodeling of visceral fat closely relates to depletion of CoQ10, lipid peroxidation, and inflammation. SN - 1539-7262 UR - https://www.unboundmedicine.com/medline/citation/26239051/Omental_adipocyte_hypertrophy_relates_to_coenzyme_Q10_redox_state_and_lipid_peroxidation_in_obese_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-2275(20)30973-1 DB - PRIME DP - Unbound Medicine ER -